MCL coexpression mm9:1169

Phase1 CAGE Peaks

	Short description
Mm9::chr18:78402606..78402617,-	p7@Slc14a2
Mm9::chr18:78402628..78402656,-	p4@Slc14a2
Mm9::chr18:78402660..78402716,-	p2@Slc14a2
Mm9::chr2:25160647..25160666,-	p3@Grin1
Mm9::chr2:4073634..4073656,+	p32@Frmd4a
Mm9::chr9:58050108..58050129,-	p17@Islr2
Mm9::chr9:58050554..58050579,-	p15@Islr2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042887	amide transporter activity	0.00443738356052032
GO:0015204	urea transmembrane transporter activity	0.00443738356052032
GO:0015840	urea transport	0.00443738356052032
GO:0042886	amide transport	0.00443738356052032
GO:0051219	phosphoprotein binding	0.023060490470473

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.47e-19	23
neuroblast (sensu Vertebrata)	1.47e-19	23
neuron	2.13e-11	33
neuronal stem cell	2.13e-11	33
neuroblast	2.13e-11	33
electrically signaling cell	2.13e-11	33
electrically responsive cell	1.34e-08	39
electrically active cell	1.34e-08	39
neuron of cerebral cortex	3.50e-08	6
neural cell	6.57e-08	43
ectodermal cell	1.40e-07	44
neurectodermal cell	1.40e-07	44

Uber Anatomy

Ontology term	p-value	n
neurectoderm	5.90e-17	64
neural plate	5.90e-17	64
presumptive neural plate	5.90e-17	64
pre-chordal neural plate	6.20e-16	49
neural tube	1.50e-14	52
neural rod	1.50e-14	52
future spinal cord	1.50e-14	52
neural keel	1.50e-14	52
regional part of nervous system	1.42e-13	54
gray matter	2.06e-13	34
ecto-epithelium	2.50e-13	73
regional part of forebrain	9.97e-13	39
forebrain	9.97e-13	39
future forebrain	9.97e-13	39
anterior neural tube	3.33e-12	40
central nervous system	9.68e-12	73
ectoderm-derived structure	2.32e-11	95
ectoderm	2.32e-11	95
presumptive ectoderm	2.32e-11	95
nervous system	4.00e-11	75
regional part of brain	2.41e-10	46
brain	5.95e-10	47
future brain	5.95e-10	47
brain grey matter	1.94e-09	29
regional part of telencephalon	1.94e-09	29
telencephalon	1.94e-09	29
structure with developmental contribution from neural crest	1.00e-08	92
basal ganglion	8.81e-07	8
nuclear complex of neuraxis	8.81e-07	8
aggregate regional part of brain	8.81e-07	8
collection of basal ganglia	8.81e-07	8
cerebral subcortex	8.81e-07	8

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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