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Coexpression cluster:C1359

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Full id: C1359_acantholytic_Mallassezderived_maxillary_renal_gastric_amniotic_Prostate



Phase1 CAGE Peaks

Hg19::chr12:28123016..28123029,-p4@PTHLH
Hg19::chr12:28123126..28123133,-p5@PTHLH
Hg19::chr12:28123174..28123181,-p7@PTHLH
Hg19::chr12:28123206..28123229,-p3@PTHLH
Hg19::chr12:28123422..28123440,-p8@PTHLH
Hg19::chr12:28124161..28124192,-p9@PTHLH


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
endo-epithelial cell1.06e-1342
epithelial cell3.38e-12253
endodermal cell1.96e-1058
respiratory epithelial cell4.34e-0913
embryonic cell1.78e-08250
Uber Anatomy
Ontology termp-valuen
anatomical system1.10e-08624
anatomical group1.40e-08625
orifice1.84e-0836
endoderm-derived structure7.97e-08160
endoderm7.97e-08160
presumptive endoderm7.97e-08160
surface structure1.00e-0799
mouth mucosa1.97e-0713
multi-cellular organism4.29e-07656
respiratory system4.82e-0774
female organism6.05e-0741
head9.51e-0756
oral opening9.58e-0722
Disease
Ontology termp-valuen
squamous cell carcinoma3.38e-0914


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90544.224134384641760.007109805478875810.0296068969062325
CTCF#1066454.466880310895860.001144848346172360.00783530907115956
RAD21#588546.903355930304220.00111085151625360.00771230615608656
SUZ12#23512541.76315075921911.86145137032345e-081.33430418438717e-06
TCF12#693847.089643268124280.001002991572657710.00718706256307363
ZBTB7A#5134144.901272871917260.004079628118843750.0194838248172637



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.