Coexpression cluster:C936
From FANTOM5_SSTAR
Full id: C936_CD4_CD14_granulocyte_CD14CD16_CD8_Dendritic_Hair
Phase1 CAGE Peaks
| Hg19::chr20:35580040..35580066,- | p3@SAMHD1 |
| Hg19::chr20:35580068..35580094,- | p1@SAMHD1 |
| Hg19::chr20:35580104..35580133,- | p2@SAMHD1 |
| Hg19::chr20:35580152..35580163,- | p5@SAMHD1 |
| Hg19::chr20:35580173..35580200,- | p4@SAMHD1 |
| Hg19::chr20:35580214..35580223,- | p7@SAMHD1 |
| Hg19::chr20:35580240..35580251,- | p6@SAMHD1 |
| Hg19::chr7:142960556..142960600,+ | p1@GSTK1 |
| Hg19::chr9:4985246..4985329,+ | p1@JAK2 |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030288 | outer membrane-bounded periplasmic space | 0.0115035799203901 |
| GO:0030313 | cell envelope | 0.0115035799203901 |
| GO:0044462 | external encapsulating structure part | 0.0115035799203901 |
| GO:0007262 | STAT protein nuclear translocation | 0.0115035799203901 |
| GO:0004718 | Janus kinase activity | 0.0115035799203901 |
| GO:0042597 | periplasmic space | 0.0115035799203901 |
| GO:0030312 | external encapsulating structure | 0.0115035799203901 |
| GO:0004716 | receptor signaling protein tyrosine kinase activity | 0.0196075728125403 |
| GO:0004602 | glutathione peroxidase activity | 0.0196075728125403 |
| GO:0015035 | protein disulfide oxidoreductase activity | 0.0196075728125403 |
| GO:0042169 | SH2 domain binding | 0.0196075728125403 |
| GO:0007260 | tyrosine phosphorylation of STAT protein | 0.0196075728125403 |
| GO:0006749 | glutathione metabolic process | 0.0196075728125403 |
| GO:0015036 | disulfide oxidoreductase activity | 0.0196746334083543 |
| GO:0000060 | protein import into nucleus, translocation | 0.0196746334083543 |
| GO:0007259 | JAK-STAT cascade | 0.0280287321429359 |
| GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 0.0280287321429359 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | 0.0280287321429359 |
| GO:0018212 | peptidyl-tyrosine modification | 0.0280287321429359 |
| GO:0004364 | glutathione transferase activity | 0.0280287321429359 |
| GO:0007498 | mesoderm development | 0.0280287321429359 |
| GO:0045121 | lipid raft | 0.0280287321429359 |
| GO:0002376 | immune system process | 0.0320820002381753 |
| GO:0004601 | peroxidase activity | 0.0359033090866457 |
| GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor | 0.0359033090866457 |
| GO:0030099 | myeloid cell differentiation | 0.0396633258639042 |
| GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups | 0.0411241581148477 |
| GO:0006790 | sulfur metabolic process | 0.0411241581148477 |
| GO:0006606 | protein import into nucleus | 0.0418241842302334 |
| GO:0051170 | nuclear import | 0.0418241842302334 |
| GO:0042579 | microbody | 0.0418241842302334 |
| GO:0005777 | peroxisome | 0.0418241842302334 |
| GO:0018193 | peptidyl-amino acid modification | 0.0479928798143188 |
| GO:0017038 | protein import | 0.0479928798143188 |
| GO:0019904 | protein domain specific binding | 0.0485252268225351 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| leukocyte | 2.27e-31 | 136 |
| nongranular leukocyte | 1.43e-30 | 115 |
| macrophage dendritic cell progenitor | 8.81e-29 | 61 |
| myeloid leukocyte | 1.74e-28 | 72 |
| monopoietic cell | 1.99e-28 | 59 |
| monocyte | 1.99e-28 | 59 |
| monoblast | 1.99e-28 | 59 |
| promonocyte | 1.99e-28 | 59 |
| granulocyte monocyte progenitor cell | 5.76e-28 | 67 |
| hematopoietic lineage restricted progenitor cell | 4.00e-27 | 120 |
| hematopoietic stem cell | 3.92e-25 | 168 |
| angioblastic mesenchymal cell | 3.92e-25 | 168 |
| defensive cell | 5.33e-25 | 48 |
| phagocyte | 5.33e-25 | 48 |
| myeloid lineage restricted progenitor cell | 2.70e-24 | 66 |
| hematopoietic oligopotent progenitor cell | 5.02e-23 | 161 |
| hematopoietic multipotent progenitor cell | 5.02e-23 | 161 |
| hematopoietic cell | 3.75e-22 | 177 |
| classical monocyte | 1.23e-21 | 42 |
| CD14-positive, CD16-negative classical monocyte | 1.23e-21 | 42 |
| myeloid cell | 1.85e-18 | 108 |
| common myeloid progenitor | 1.85e-18 | 108 |
| stuff accumulating cell | 1.09e-16 | 87 |
| mature alpha-beta T cell | 1.87e-09 | 18 |
| alpha-beta T cell | 1.87e-09 | 18 |
| immature T cell | 1.87e-09 | 18 |
| mature T cell | 1.87e-09 | 18 |
| immature alpha-beta T cell | 1.87e-09 | 18 |
| Ontology term | p-value | n |
|---|---|---|
| hematopoietic system | 2.43e-30 | 98 |
| blood island | 2.43e-30 | 98 |
| hemolymphoid system | 3.85e-30 | 108 |
| immune system | 1.69e-25 | 93 |
| bone marrow | 6.38e-24 | 76 |
| adult organism | 3.58e-22 | 114 |
| bone element | 2.78e-19 | 82 |
| skeletal element | 2.37e-18 | 90 |
| skeletal system | 1.13e-16 | 100 |
| lateral plate mesoderm | 1.24e-09 | 203 |
| musculoskeletal system | 2.52e-07 | 167 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)
| TF | #promoters | Enrichment | p-value | q-value |
|---|---|---|---|---|
| ATF3#467 | 7 | 17.4713579646735 | 1.14940906869096e-08 | 8.6237883423143e-07 |
| CTCF#10664 | 8 | 4.76467233162225 | 1.10088565904027e-05 | 0.000285015858563477 |
| CTCFL#140690 | 8 | 17.5524216524216 | 3.70770685210878e-10 | 3.6914127352468e-08 |
| E2F1#1869 | 8 | 4.3621237465594 | 2.18983367577486e-05 | 0.000481279543906252 |
| E2F4#1874 | 7 | 9.85293580077679 | 5.95188909661047e-07 | 2.73716136222326e-05 |
| E2F6#1876 | 9 | 5.01715573169739 | 4.96068808485209e-07 | 2.32431270925916e-05 |
| HEY1#23462 | 9 | 4.04011104310571 | 3.4850025352467e-06 | 0.000115987947666868 |
| HMGN3#9324 | 8 | 7.26982019853386 | 4.00320733604597e-07 | 1.93560634708012e-05 |
| JUN#3725 | 7 | 9.73220048292826 | 6.47658215823223e-07 | 2.93834823641883e-05 |
| MXI1#4601 | 7 | 7.74788904459056 | 3.07469224127045e-06 | 0.000103720214142779 |
| NANOG#79923 | 7 | 22.7459388185654 | 1.84595149658852e-09 | 1.59991143860754e-07 |
| NRF1#4899 | 9 | 12.2102794477109 | 1.65394511709215e-10 | 1.73604396064308e-08 |
| PAX5#5079 | 5 | 3.70531418398768 | 0.00561655707771942 | 0.0253945021273621 |
| PBX3#5090 | 7 | 17.0446209785788 | 1.36394115359822e-08 | 1.00315950803271e-06 |
| POLR2A#5430 | 9 | 2.14745317655807 | 0.00102941289260802 | 0.00728887139600606 |
| RFX5#5993 | 7 | 9.37059731004063 | 8.3937256470655e-07 | 3.65111333966628e-05 |
| SIN3A#25942 | 8 | 4.80789753494679 | 1.02597602607548e-05 | 0.000268080836095314 |
| TAF1#6872 | 9 | 3.34304628574529 | 1.91655056102793e-05 | 0.000433533948544935 |
| TBP#6908 | 9 | 3.70677068709639 | 7.56501052505806e-06 | 0.000215928432420481 |
| TCF7L2#6934 | 7 | 8.37680399355127 | 1.80610965338292e-06 | 6.77300847718704e-05 |
| TFAP2A#7020 | 8 | 14.6832305538177 | 1.5325776526732e-09 | 1.35415293965767e-07 |
| TFAP2C#7022 | 8 | 9.60820320876464 | 4.42575919806395e-08 | 2.89794272656176e-06 |
| THAP1#55145 | 7 | 24.3982235799955 | 1.13434844000145e-09 | 1.04195441271162e-07 |
| ZEB1#6935 | 3 | 5.62947733918129 | 0.0133048823634195 | 0.0470379678803415 |
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
