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Coexpression cluster:C92

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Full id: C92_CD14CD16_CD14_Eosinophils_Basophils_Neutrophils_Macrophage_Whole



Phase1 CAGE Peaks

Hg19::chr10:101379080..101379085,+p@chr10:101379080..101379085
+
Hg19::chr10:104556220..104556247,-p@chr10:104556220..104556247
-
Hg19::chr10:104556407..104556425,+p@chr10:104556407..104556425
+
Hg19::chr10:114594528..114594539,-p@chr10:114594528..114594539
-
Hg19::chr10:114885446..114885465,+p@chr10:114885446..114885465
+
Hg19::chr10:115070193..115070207,-p@chr10:115070193..115070207
-
Hg19::chr10:115080077..115080087,-p@chr10:115080077..115080087
-
Hg19::chr10:43609342..43609351,+p@chr10:43609342..43609351
+
Hg19::chr10:73473819..73473836,+p@chr10:73473819..73473836
+
Hg19::chr10:73534273..73534295,-p@chr10:73534273..73534295
-
Hg19::chr10:73588893..73588912,-p@chr10:73588893..73588912
-
Hg19::chr10:81742364..81742375,-p2@SFTPD
Hg19::chr11:117056662..117056716,+p7@SIDT2
Hg19::chr11:117056719..117056726,+p28@SIDT2
Hg19::chr11:117056730..117056740,+p15@SIDT2
Hg19::chr11:117056889..117056905,+p21@SIDT2
Hg19::chr11:122614916..122614928,+p@chr11:122614916..122614928
+
Hg19::chr11:2323009..2323021,-p7@C11orf21
Hg19::chr11:2905326..2905374,-p@chr11:2905326..2905374
-
Hg19::chr11:504207..504213,+p@chr11:504207..504213
+
Hg19::chr11:60146107..60146118,+p6@MS4A7
Hg19::chr11:67051186..67051245,+p3@ADRBK1
Hg19::chr11:67415202..67415246,-p5@ACY3
Hg19::chr12:117504933..117504940,-p@chr12:117504933..117504940
-
Hg19::chr12:121976319..121976333,-p@chr12:121976319..121976333
-
Hg19::chr12:123752764..123752835,-p7@CDK2AP1
Hg19::chr12:123752843..123752879,-p10@CDK2AP1
Hg19::chr12:12871327..12871345,+p@chr12:12871327..12871345
+
Hg19::chr12:29727591..29727616,-p@chr12:29727591..29727616
-
Hg19::chr14:101150099..101150117,+p@chr14:101150099..101150117
+
Hg19::chr14:101150133..101150145,+p@chr14:101150133..101150145
+
Hg19::chr14:105954292..105954314,+p7@CRIP1
Hg19::chr14:23282256..23282282,-p17@SLC7A7
Hg19::chr14:52782082..52782100,-p@chr14:52782082..52782100
-
Hg19::chr14:52782111..52782133,-p@chr14:52782111..52782133
-
Hg19::chr14:92927429..92927462,+p@chr14:92927429..92927462
+
Hg19::chr14:92927464..92927488,+p@chr14:92927464..92927488
+
Hg19::chr15:22538560..22538601,-p@chr15:22538560..22538601
-
Hg19::chr15:22550722..22550726,+p@chr15:22550722..22550726
+
Hg19::chr15:38296918..38296944,+p1@ENST00000557883
Hg19::chr15:75080883..75080890,+p14@CSK
Hg19::chr15:75422284..75422300,-p@chr15:75422284..75422300
-
Hg19::chr15:86098640..86098665,+p13@AKAP13
Hg19::chr16:1538765..1538796,-p1@PTX4
Hg19::chr16:1538881..1538887,+p@chr16:1538881..1538887
+
Hg19::chr16:17460967..17460974,-p@chr16:17460967..17460974
-
Hg19::chr16:19179856..19179908,+p2@SYT17
Hg19::chr16:30484090..30484101,+p4@ITGAL
Hg19::chr16:4563100..4563144,-p12@C16orf5
Hg19::chr16:50313353..50313370,+p@chr16:50313353..50313370
+
Hg19::chr16:67429107..67429142,-p@chr16:67429107..67429142
-
Hg19::chr16:67429148..67429159,-p@chr16:67429148..67429159
-
Hg19::chr16:67429168..67429188,-p@chr16:67429168..67429188
-
Hg19::chr16:68032947..68032953,+p@chr16:68032947..68032953
+
Hg19::chr16:85096580..85096602,+p3@KIAA0513
Hg19::chr17:40351201..40351230,+p@chr17:40351201..40351230
+
Hg19::chr17:47287786..47287800,-p@chr17:47287786..47287800
-
Hg19::chr17:47288020..47288029,+p3@ABI3
Hg19::chr17:48870630..48870661,+p@chr17:48870630..48870661
+
Hg19::chr17:531650..531657,-p@chr17:531650..531657
-
Hg19::chr17:531669..531692,-p@chr17:531669..531692
-
Hg19::chr17:531709..531723,-p@chr17:531709..531723
-
Hg19::chr17:61776536..61776553,-p@chr17:61776536..61776553
-
Hg19::chr17:61776579..61776588,-p@chr17:61776579..61776588
-
Hg19::chr17:61777090..61777112,-p7@LIMD2
Hg19::chr17:72439704..72439736,+p8@GPRC5C
Hg19::chr17:72563495..72563524,-p3@ENST00000425002
Hg19::chr17:72563552..72563583,-p1@ENST00000425002
Hg19::chr17:72563586..72563601,-p5@ENST00000425002
Hg19::chr17:72563622..72563633,-p4@ENST00000425002
Hg19::chr17:72563639..72563654,-p2@ENST00000425002
Hg19::chr17:72595953..72595966,+p@chr17:72595953..72595966
+
Hg19::chr17:72595971..72595990,+p@chr17:72595971..72595990
+
Hg19::chr17:72595995..72596020,+p@chr17:72595995..72596020
+
Hg19::chr17:75430998..75431040,+p@chr17:75430998..75431040
+
Hg19::chr17:75440858..75440875,+p1@ENST00000450721
Hg19::chr17:76123130..76123168,-p13@TMC6
Hg19::chr17:80064388..80064407,-p@chr17:80064388..80064407
-
Hg19::chr17:80843910..80843933,+p@chr17:80843910..80843933
+
Hg19::chr17:81103313..81103332,-p@chr17:81103313..81103332
-
Hg19::chr18:13569295..13569309,+p@chr18:13569295..13569309
+
Hg19::chr19:10959147..10959176,+p2@C19orf38
Hg19::chr19:14546214..14546245,+p@chr19:14546214..14546245
+
Hg19::chr19:14887911..14887932,-p3@EMR2
Hg19::chr19:18283959..18283993,+p@chr19:18283959..18283993
+
Hg19::chr19:18507990..18508011,-p3@LRRC25
Hg19::chr19:18529581..18529594,+p@chr19:18529581..18529594
+
Hg19::chr19:18529684..18529699,+p6@SSBP4
Hg19::chr19:36398384..36398407,+p@chr19:36398384..36398407
+
Hg19::chr19:47614483..47614496,-p@chr19:47614483..47614496
-
Hg19::chr19:47834063..47834081,+p@chr19:47834063..47834081
+
Hg19::chr19:50283657..50283673,+p@chr19:50283657..50283673
+
Hg19::chr19:50283684..50283702,+p@chr19:50283684..50283702
+
Hg19::chr19:50284801..50284815,+p@chr19:50284801..50284815
+
Hg19::chr19:50284821..50284856,+p@chr19:50284821..50284856
+
Hg19::chr19:50285177..50285181,+p@chr19:50285177..50285181
+
Hg19::chr19:54710115..54710150,+p@chr19:54710115..54710150
+
Hg19::chr19:55105085..55105136,+p1@LILRA1
Hg19::chr19:55128414..55128437,+p4@LILRB1
Hg19::chr19:55207635..55207643,+p@chr19:55207635..55207643
+
Hg19::chr1:112016594..112016617,+p1@C1orf162
Hg19::chr1:12185656..12185684,+p10@TNFRSF8
Hg19::chr1:12185997..12186018,+p5@TNFRSF8
Hg19::chr1:161519583..161519620,-p1@FCGR3A
Hg19::chr1:161519682..161519691,-p7@FCGR3A
Hg19::chr1:161600900..161600923,-p3@FCGR3B
p4@FCGR3A
Hg19::chr1:181104200..181104242,+p@chr1:181104200..181104242
+
Hg19::chr1:192128293..192128310,+p@chr1:192128293..192128310
+
Hg19::chr1:192128363..192128374,+p@chr1:192128363..192128374
+
Hg19::chr1:26186028..26186052,+p1@ENST00000455431
Hg19::chr1:26186058..26186081,+p2@ENST00000455431
Hg19::chr1:26634917..26634921,+p@chr1:26634917..26634921
+
Hg19::chr20:30793004..30793008,-p@chr20:30793004..30793008
-
Hg19::chr20:62708461..62708503,-p7@RGS19
Hg19::chr20:62711482..62711505,+p4@OPRL1
Hg19::chr20:825275..825293,+p3@FAM110A
Hg19::chr20:825297..825306,+p7@FAM110A
Hg19::chr20:825327..825342,+p4@FAM110A
Hg19::chr20:827656..827661,-p@chr20:827656..827661
-
Hg19::chr21:44765881..44765892,-p@chr21:44765881..44765892
-
Hg19::chr21:45232138..45232176,-p1@LOC284837
Hg19::chr21:45232423..45232443,-p2@LOC284837
Hg19::chr22:30714833..30714846,-p4@TBC1D10A
Hg19::chr2:219125714..219125758,+p1@GPBAR1
Hg19::chr2:219125814..219125822,+p3@GPBAR1
Hg19::chr2:219125838..219125849,+p2@GPBAR1
Hg19::chr2:238600416..238600432,-p@chr2:238600416..238600432
-
Hg19::chr2:241906812..241906837,-p2@LOC200772
Hg19::chr2:241906841..241906868,-p1@LOC200772
Hg19::chr2:241906877..241906887,-p3@LOC200772
Hg19::chr2:29337060..29337092,+p3@CLIP4
Hg19::chr2:29337097..29337111,+p10@CLIP4
Hg19::chr2:29337114..29337117,+p21@CLIP4
Hg19::chr2:71047727..71047733,-p1@CLEC4F
Hg19::chr3:101597149..101597179,+p@chr3:101597149..101597179
+
Hg19::chr3:132036352..132036365,+p6@ACPP
Hg19::chr3:132036369..132036382,+p5@ACPP
Hg19::chr3:196417056..196417097,+p@chr3:196417056..196417097
+
Hg19::chr3:39321512..39321533,-p1@CX3CR1
Hg19::chr3:46968769..46968781,-p@chr3:46968769..46968781
-
Hg19::chr3:50658125..50658131,+p@chr3:50658125..50658131
+
Hg19::chr3:50658577..50658589,+p@chr3:50658577..50658589
+
Hg19::chr4:1582183..1582209,-p1@ENST00000466692
Hg19::chr4:2787568..2787572,+p@chr4:2787568..2787572
+
Hg19::chr4:2794535..2794549,-p@chr4:2794535..2794549
-
Hg19::chr4:3374958..3374970,+p@chr4:3374958..3374970
+
Hg19::chr4:76861392..76861418,-p3@NAAA
Hg19::chr4:76862117..76862186,-p1@NAAA
Hg19::chr5:114887365..114887382,+p@chr5:114887365..114887382
+
Hg19::chr5:14331744..14331753,+p@chr5:14331744..14331753
+
Hg19::chr5:14331797..14331811,+p@chr5:14331797..14331811
+
Hg19::chr5:169064317..169064332,+p2@DOCK2
Hg19::chr5:171601123..171601129,+p@chr5:171601123..171601129
+
Hg19::chr5:172232848..172232850,-p@chr5:172232848..172232850
-
Hg19::chr5:180237681..180237700,+p2@BC017750
Hg19::chr5:56112783..56112806,+p@chr5:56112783..56112806
+
Hg19::chr5:76145904..76145918,+p3@S100Z
Hg19::chr5:76145920..76145948,+p2@S100Z
Hg19::chr6:116782527..116782550,+p4@FAM26F
Hg19::chr6:144952186..144952227,+p@chr6:144952186..144952227
+
Hg19::chr6:144980477..144980514,+p4@UTRN
Hg19::chr6:144980558..144980569,+p30@UTRN
Hg19::chr6:144980756..144980774,+p22@UTRN
Hg19::chr6:144980777..144980799,+p13@UTRN
Hg19::chr6:144980861..144980870,+p38@UTRN
Hg19::chr6:144980916..144980928,+p23@UTRN
Hg19::chr6:144980954..144980988,+p11@UTRN
Hg19::chr6:144981000..144981016,+p14@UTRN
Hg19::chr6:31553978..31554060,+p1@LST1
Hg19::chr6:31554755..31554764,+p11@LST1
Hg19::chr6:31554766..31554777,+p8@LST1
Hg19::chr6:31554826..31554845,+p4@LST1
Hg19::chr6:31554962..31554987,+p5@LST1
Hg19::chr6:31554992..31555041,+p2@LST1
Hg19::chr6:31555045..31555057,+p9@LST1
Hg19::chr6:31582990..31583096,+p1@AIF1
Hg19::chr6:31584663..31584673,-p@chr6:31584663..31584673
-
Hg19::chr7:101923300..101923343,+p@chr7:101923300..101923343
+
Hg19::chr7:155055063..155055078,+p@chr7:155055063..155055078
+
Hg19::chr7:20581331..20581339,-p@chr7:20581331..20581339
-
Hg19::chr7:20581377..20581387,-p@chr7:20581377..20581387
-
Hg19::chr7:2673037..2673047,-p@chr7:2673037..2673047
-
Hg19::chr7:2673206..2673216,+p@chr7:2673206..2673216
+
Hg19::chr7:2673688..2673709,-p@chr7:2673688..2673709
-
Hg19::chr7:5596053..5596074,-p@chr7:5596053..5596074
-
Hg19::chr7:77429034..77429040,-p@chr7:77429034..77429040
-
Hg19::chr8:142384243..142384251,+p@chr8:142384243..142384251
+
Hg19::chr8:142384271..142384329,+p@chr8:142384271..142384329
+
Hg19::chr8:143833918..143833960,-p1@LYPD2
Hg19::chr8:143833961..143833974,-p2@LYPD2
Hg19::chr8:144480343..144480350,-p@chr8:144480343..144480350
-
Hg19::chr8:37439077..37439090,+p@chr8:37439077..37439090
+
Hg19::chr8:38758006..38758019,+p@chr8:38758006..38758019
+
Hg19::chr8:52811117..52811133,+p@chr8:52811117..52811133
+
Hg19::chr9:130540914..130540932,-p5@SH2D3C
Hg19::chr9:136709727..136709738,+p@chr9:136709727..136709738
+
Hg19::chr9:137267629..137267639,-p@chr9:137267629..137267639
-
Hg19::chr9:137267647..137267658,-p@chr9:137267647..137267658
-
Hg19::chr9:138967894..138967906,-p@chr9:138967894..138967906
-
Hg19::chr9:140348244..140348308,-p@chr9:140348244..140348308
-
Hg19::chrX:70712265..70712303,+p4@TAF1
Hg19::chrY:2870975..2870988,+p1@LINC00278


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016020membrane9.32023741352661e-06
GO:0004871signal transducer activity4.97454272835934e-05
GO:0060089molecular transducer activity4.97454272835934e-05
GO:0044425membrane part0.000885377741452317
GO:0008285negative regulation of cell proliferation0.0010982489843916
GO:0019864IgG binding0.00389780543213328
GO:0050672negative regulation of lymphocyte proliferation0.00492500838025483
GO:0032945negative regulation of mononuclear cell proliferation0.00492500838025483
GO:0048523negative regulation of cellular process0.00492500838025483
GO:0004872receptor activity0.00492500838025483
GO:0044464cell part0.00492500838025483
GO:0048519negative regulation of biological process0.00520183320258003
GO:0019865immunoglobulin binding0.00688185411257371
GO:0016021integral to membrane0.00688185411257371
GO:0031224intrinsic to membrane0.00688185411257371
GO:0005886plasma membrane0.00688185411257371
GO:0051250negative regulation of lymphocyte activation0.00832577728169739
GO:0032403protein complex binding0.00879372966006079
GO:0042127regulation of cell proliferation0.00921920829385283
GO:0008283cell proliferation0.00968728738051494
GO:0030595leukocyte chemotaxis0.00993913319223597
GO:0050900leukocyte migration0.0173228094301686
GO:0042330taxis0.0181469423724365
GO:0006935chemotaxis0.0181469423724365
GO:0007166cell surface receptor linked signal transduction0.0181469423724365
GO:0006952defense response0.0181469423724365
GO:0007165signal transduction0.018334818823925
GO:0045554regulation of TRAIL biosynthetic process0.0188999696750325
GO:0043129surfactant homeostasis0.0188999696750325
GO:0045553TRAIL biosynthetic process0.0188999696750325
GO:0048875chemical homeostasis within a tissue0.0188999696750325
GO:0032639TRAIL production0.0188999696750325
GO:0045556positive regulation of TRAIL biosynthetic process0.0188999696750325
GO:0009605response to external stimulus0.0188999696750325
GO:0005737cytoplasm0.0188999696750325
GO:0032944regulation of mononuclear cell proliferation0.0188999696750325
GO:0050670regulation of lymphocyte proliferation0.0188999696750325
GO:0006928cell motility0.0198542754536055
GO:0051674localization of cell0.0198542754536055
GO:0007626locomotory behavior0.0214749844586034
GO:0002376immune system process0.0236206013010033
GO:0030695GTPase regulator activity0.0249523236786799
GO:0032943mononuclear cell proliferation0.0252075945113539
GO:0046651lymphocyte proliferation0.0252075945113539
GO:0044459plasma membrane part0.0260685840256939
GO:0005515protein binding0.0276131105418551
GO:0019807aspartoacylase activity0.0276131105418551
GO:0047696beta-adrenergic receptor kinase activity0.0276131105418551
GO:0042035regulation of cytokine biosynthetic process0.0289078836085141
GO:0007154cell communication0.0299010405478368
GO:0016477cell migration0.0331147653005901
GO:0042089cytokine biosynthetic process0.0331147653005901
GO:0042107cytokine metabolic process0.0331147653005901
GO:0033209tumor necrosis factor-mediated signaling pathway0.0331147653005901
GO:0048286alveolus development0.0331147653005901
GO:0022401adaptation of signaling pathway0.0331147653005901
GO:0008157protein phosphatase 1 binding0.0331147653005901
GO:0002029desensitization of G-protein coupled receptor protein signaling pathway0.0331147653005901
GO:0045085negative regulation of interleukin-2 biosynthetic process0.0331147653005901
GO:0042608T cell receptor binding0.0331147653005901
GO:0006955immune response0.0344981384493859
GO:0051249regulation of lymphocyte activation0.0363072331852681
GO:0050865regulation of cell activation0.0389339002729788
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway0.0389339002729788
GO:0048246macrophage chemotaxis0.0389339002729788
GO:0048247lymphocyte chemotaxis0.0389339002729788
GO:0015051X-opioid receptor activity0.0389339002729788
GO:0004046aminoacylase activity0.0389339002729788
GO:0007186G-protein coupled receptor protein signaling pathway0.039985979963799
GO:0051329interphase of mitotic cell cycle0.039985979963799
GO:0051239regulation of multicellular organismal process0.0400152244196185
GO:0000267cell fraction0.0427906431484107
GO:0051325interphase0.0428389829493994
GO:0050828regulation of liquid surface tension0.0440488207431105
GO:0042535positive regulation of tumor necrosis factor biosynthetic process0.0440488207431105
GO:0007610behavior0.0440488207431105
GO:0005085guanyl-nucleotide exchange factor activity0.0498283844727028



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell1.24e-55172
angioblastic mesenchymal cell1.24e-55172
hematopoietic cell6.17e-52182
hematopoietic oligopotent progenitor cell7.04e-52165
hematopoietic multipotent progenitor cell7.04e-52165
leukocyte5.66e-49140
hematopoietic lineage restricted progenitor cell2.16e-40124
myeloid cell3.21e-40112
common myeloid progenitor3.21e-40112
nongranular leukocyte1.19e-39119
myeloid leukocyte1.22e-3476
granulocyte monocyte progenitor cell3.58e-3171
myeloid lineage restricted progenitor cell1.34e-2970
macrophage dendritic cell progenitor2.39e-2965
monopoietic cell2.35e-2863
monocyte2.35e-2863
monoblast2.35e-2863
promonocyte2.35e-2863
CD14-positive, CD16-negative classical monocyte1.08e-2742
classical monocyte9.02e-2545
lymphocyte1.87e-1053
common lymphoid progenitor1.87e-1053
lymphoid lineage restricted progenitor cell2.06e-1052
intermediate monocyte1.91e-079
CD14-positive, CD16-positive monocyte1.91e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.85e-33102
blood island1.85e-33102
hemolymphoid system1.16e-30112
bone marrow2.57e-2580
adult organism3.27e-25115
immune system5.16e-21115
bone element6.67e-2086
skeletal element7.88e-14101
skeletal system7.88e-14101
lateral plate mesoderm4.71e-08216
neural tube5.96e-0857
neural rod5.96e-0857
future spinal cord5.96e-0857
neural keel5.96e-0857
anterior neural tube8.00e-0742
blood8.20e-0715
haemolymphatic fluid8.20e-0715
organism substance8.20e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SPI1#6688592.396312311895258.62809779252941e-119.43570581522491e-09



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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