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Coexpression cluster:C788

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Full id: C788_umbilical_aorta_smooth_bladder_penis_colon_heart



Phase1 CAGE Peaks

Hg19::chr10:90694948..90695025,-p@chr10:90694948..90695025
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Hg19::chr10:90713570..90713574,+p@chr10:90713570..90713574
+
Hg19::chr10:97181754..97181768,-p14@SORBS1
Hg19::chr13:111164792..111164826,+p@chr13:111164792..111164826
+
Hg19::chr1:10683041..10683058,+p@chr1:10683041..10683058
+
Hg19::chr3:78684991..78684993,-p@chr3:78684991..78684993
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Hg19::chr4:186578715..186578746,-p27@SORBS2
Hg19::chr5:156810234..156810257,+p4@CYFIP2
Hg19::chr5:169805660..169805676,-p@chr5:169805660..169805676
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Hg19::chr9:127270402..127270409,-p@chr9:127270402..127270409
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005915zonula adherens0.0139351277842367
GO:0030054cell junction0.0139351277842367
GO:0043149stress fiber formation0.0139351277842367
GO:0001725stress fiber0.0139351277842367
GO:0032432actin filament bundle0.0139351277842367
GO:0048041focal adhesion formation0.0139351277842367
GO:0005913cell-cell adherens junction0.0139351277842367
GO:0051017actin filament bundle formation0.0159985789095684
GO:0005158insulin receptor binding0.0159985789095684
GO:0022610biological adhesion0.0159985789095684
GO:0007155cell adhesion0.0159985789095684
GO:0015758glucose transport0.0159985789095684
GO:0008645hexose transport0.0159985789095684
GO:0008286insulin receptor signaling pathway0.0159985789095684
GO:0015749monosaccharide transport0.0159985789095684
GO:0019717synaptosome0.0161784847753573
GO:0005924cell-substrate adherens junction0.0161784847753573
GO:0030055cell-matrix junction0.0161784847753573
GO:0007015actin filament organization0.0161784847753573
GO:0045121lipid raft0.017241358258977
GO:0005912adherens junction0.0192715116061175
GO:0048471perinuclear region of cytoplasm0.0217956935098357
GO:0016323basolateral plasma membrane0.0276716988629033
GO:0007160cell-matrix adhesion0.0280620941312236
GO:0032403protein complex binding0.0280620941312236
GO:0031589cell-substrate adhesion0.0280620941312236
GO:0043296apical junction complex0.0280620941312236
GO:0016327apicolateral plasma membrane0.0280620941312236
GO:0008643carbohydrate transport0.0286376253616859
GO:0044459plasma membrane part0.0367167446690375
GO:0005911intercellular junction0.0416776000298609
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0489568766360709



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.08e-24115
anatomical conduit1.20e-10241
anatomical cluster2.04e-10286
central nervous system2.16e-1082
multi-cellular organism2.99e-10659
regional part of nervous system1.39e-0994
nervous system1.39e-0994
neural tube1.55e-0957
neural rod1.55e-0957
future spinal cord1.55e-0957
neural keel1.55e-0957
tube2.04e-09194
regional part of brain2.95e-0959
brain1.12e-0869
future brain1.12e-0869
organism subdivision5.59e-08365
neural plate7.93e-0886
presumptive neural plate7.93e-0886
anterior neural tube1.09e-0742
neurectoderm1.30e-0790
regional part of forebrain2.56e-0741
forebrain2.56e-0741
future forebrain2.56e-0741
multi-tissue structure4.26e-07347
telencephalon6.38e-0734
regional part of telencephalon7.37e-0733
gray matter7.61e-0734
brain grey matter7.61e-0734
anatomical system8.01e-07625


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.