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Coexpression cluster:C2920

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Full id: C2920_liver_Mesenchymal_Neutrophils_Osteoblast_Melanocyte_testis_CD14



Phase1 CAGE Peaks

Hg19::chr8:145065410..145065446,+p7@GRINA
Hg19::chr8:145065457..145065489,+p6@GRINA
Hg19::chr8:145065521..145065547,+p9@GRINA
Hg19::chr8:145065705..145065731,+p5@GRINA


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multi-cellular organism2.76e-18659
anatomical system4.77e-17625
anatomical group1.03e-16626
germ layer2.11e-15604
embryonic tissue2.11e-15604
presumptive structure2.11e-15604
epiblast (generic)2.11e-15604
embryonic structure3.68e-15605
developing anatomical structure3.68e-15605
embryo6.51e-15612
adult organism6.80e-13115
lateral plate mesoderm1.07e-09216
mesoderm3.42e-09448
mesoderm-derived structure3.42e-09448
presumptive mesoderm3.42e-09448
organ7.47e-09511
immune system1.77e-08115
hemolymphoid system3.05e-08112
hematopoietic system1.29e-07102
blood island1.29e-07102
bone marrow1.58e-0780
bone element4.31e-0786
musculoskeletal system4.32e-07167
anatomical conduit4.97e-07241
skeletal element7.20e-07101
skeletal system7.20e-07101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90534.752151182721970.01386206996689490.0487487617103015
ETS1#211337.296570691651750.00400857377511390.0192147712731376
ZBTB7A#5134135.513931980906920.009038352821081090.0342633949285259



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.