MCL coexpression mm9:1284

Phase1 CAGE Peaks

	Short description
Mm9::chr11:33863206..33863243,+	p2@Kcnmb1
Mm9::chr11:33863281..33863297,+	p1@Kcnmb1
Mm9::chr19:40735141..40735154,+	p6@Entpd1
Mm9::chr19:40735165..40735184,+	p5@Entpd1
Mm9::chr1:75358590..75358619,+	p3@Des
Mm9::chrX:80194418..80194429,+	p17@Dmd

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005626	insoluble fraction	0.000320721918700239
GO:0005605	basal lamina	0.000633274535833115
GO:0042383	sarcolemma	0.000633274535833115
GO:0030018	Z disc	0.000633274535833115
GO:0031674	I band	0.000653173538217342
GO:0005604	basement membrane	0.00169525293364805
GO:0030017	sarcomere	0.00169525293364805
GO:0044449	contractile fiber part	0.00169525293364805
GO:0030016	myofibril	0.00169525293364805
GO:0043292	contractile fiber	0.00169525293364805
GO:0005886	plasma membrane	0.00169525293364805
GO:0044420	extracellular matrix part	0.00202213373248082
GO:0006200	ATP catabolic process	0.00507115656574754
GO:0009207	purine ribonucleoside triphosphate catabolic process	0.00507115656574754
GO:0007517	muscle development	0.00526387084088259
GO:0009137	purine nucleoside diphosphate catabolic process	0.00591586310026468
GO:0009181	purine ribonucleoside diphosphate catabolic process	0.00591586310026468
GO:0009203	ribonucleoside triphosphate catabolic process	0.00591586310026468
GO:0009146	purine nucleoside triphosphate catabolic process	0.00676043075353872
GO:0009179	purine ribonucleoside diphosphate metabolic process	0.00676043075353872
GO:0009135	purine nucleoside diphosphate metabolic process	0.00676043075353872
GO:0009154	purine ribonucleotide catabolic process	0.00771507489645553
GO:0009191	ribonucleoside diphosphate catabolic process	0.00771507489645553
GO:0009143	nucleoside triphosphate catabolic process	0.00788587284542905
GO:0009185	ribonucleoside diphosphate metabolic process	0.00788587284542905
GO:0045213	neurotransmitter receptor metabolic process	0.00788587284542905
GO:0009134	nucleoside diphosphate catabolic process	0.00788587284542905
GO:0005578	proteinaceous extracellular matrix	0.00791926210191326
GO:0006195	purine nucleotide catabolic process	0.00827948596959745
GO:0009261	ribonucleotide catabolic process	0.00827948596959745
GO:0046716	muscle maintenance	0.0102999713008809
GO:0017110	nucleoside-diphosphatase activity	0.0110858634557424
GO:0030168	platelet activation	0.0114761859250077
GO:0015269	calcium-activated potassium channel activity	0.0114761859250077
GO:0016010	dystrophin-associated glycoprotein complex	0.0121607766733126
GO:0022839	ion gated channel activity	0.0124610329072939
GO:0009132	nucleoside diphosphate metabolic process	0.0124610329072939
GO:0005227	calcium activated cation channel activity	0.0130653532658187
GO:0000267	cell fraction	0.0177110898669781
GO:0009166	nucleotide catabolic process	0.0194918841001994
GO:0043112	receptor metabolic process	0.0216042991580266
GO:0065008	regulation of biological quality	0.0246739804297449
GO:0045121	lipid raft	0.027994529518183
GO:0030055	cell-matrix junction	0.0281606306010075
GO:0046034	ATP metabolic process	0.0314554543040692
GO:0005509	calcium ion binding	0.0360135941448607
GO:0009205	purine ribonucleoside triphosphate metabolic process	0.0360135941448607
GO:0009199	ribonucleoside triphosphate metabolic process	0.0360135941448607
GO:0009144	purine nucleoside triphosphate metabolic process	0.0360135941448607
GO:0007596	blood coagulation	0.0360135941448607
GO:0007599	hemostasis	0.0360135941448607
GO:0008076	voltage-gated potassium channel complex	0.0360135941448607
GO:0050817	coagulation	0.0360135941448607
GO:0009141	nucleoside triphosphate metabolic process	0.0366497842386897
GO:0005856	cytoskeleton	0.0366919040790318
GO:0009150	purine ribonucleotide metabolic process	0.0403629970653441
GO:0050878	regulation of body fluid levels	0.041881593998687
GO:0009259	ribonucleotide metabolic process	0.041881593998687
GO:0016323	basolateral plasma membrane	0.041881593998687
GO:0006163	purine nucleotide metabolic process	0.0435225948139612
GO:0042060	wound healing	0.0456828279462791

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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