MCL coexpression mm9:1060

Phase1 CAGE Peaks

	Short description
Mm9::chr11:115836183..115836190,+	p16@Itgb4
Mm9::chr1:159186758..159186781,-	p5@Rasal2
Mm9::chr2:71625071..71625102,+	p3@Itga6
Mm9::chr2:71625114..71625140,+	p2@Itga6
Mm9::chr4:96214495..96214500,-	p@chr4:96214495..96214500 -
Mm9::chrX:82018040..82018058,+	p4@Dmd
Mm9::chrX:82018062..82018069,+	p25@Dmd

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0016323	basolateral plasma membrane	6.91408372259676e-06
GO:0046847	filopodium formation	3.45685239974223e-05
GO:0030035	microspike biogenesis	3.45685239974223e-05
GO:0008305	integrin complex	0.000322932264887892
GO:0030031	cell projection biogenesis	0.000519188727130741
GO:0007160	cell-matrix adhesion	0.000726398330933817
GO:0031589	cell-substrate adhesion	0.000726398330933817
GO:0043235	receptor complex	0.000734641541604711
GO:0007229	integrin-mediated signaling pathway	0.00104547518096533
GO:0044459	plasma membrane part	0.00560911464321391
GO:0043234	protein complex	0.00560911464321391
GO:0032990	cell part morphogenesis	0.00560911464321391
GO:0030030	cell projection organization and biogenesis	0.00560911464321391
GO:0048858	cell projection morphogenesis	0.00560911464321391
GO:0022409	positive regulation of cell-cell adhesion	0.00560911464321391
GO:0033627	cell adhesion mediated by integrin	0.00657282106793939
GO:0045213	neurotransmitter receptor metabolic process	0.00742301469348088
GO:0005886	plasma membrane	0.00763556598579442
GO:0048856	anatomical structure development	0.00763556598579442
GO:0032991	macromolecular complex	0.00788565669744276
GO:0009925	basal plasma membrane	0.00788565669744276
GO:0046716	muscle maintenance	0.00788565669744276
GO:0045178	basal part of cell	0.00788565669744276
GO:0022407	regulation of cell-cell adhesion	0.00788565669744276
GO:0007275	multicellular organismal development	0.00813724320940646
GO:0005626	insoluble fraction	0.00840998445350211
GO:0000902	cell morphogenesis	0.00840998445350211
GO:0032989	cellular structure morphogenesis	0.00840998445350211
GO:0016010	dystrophin-associated glycoprotein complex	0.00840998445350211
GO:0045785	positive regulation of cell adhesion	0.00840998445350211
GO:0022610	biological adhesion	0.0121661972780957
GO:0007155	cell adhesion	0.0121661972780957
GO:0005178	integrin binding	0.013635432305403
GO:0032502	developmental process	0.013635432305403
GO:0043112	receptor metabolic process	0.0150071331185883
GO:0005605	basal lamina	0.0151730473234393
GO:0042383	sarcolemma	0.0158968347703766
GO:0030018	Z disc	0.0164326859735878
GO:0050900	leukocyte migration	0.0164326859735878
GO:0005509	calcium ion binding	0.0164326859735878
GO:0031674	I band	0.0164326859735878
GO:0045121	lipid raft	0.0164326859735878
GO:0005887	integral to plasma membrane	0.0164326859735878
GO:0030055	cell-matrix junction	0.0164326859735878
GO:0031226	intrinsic to plasma membrane	0.0164326859735878
GO:0042475	odontogenesis of dentine-containing teeth	0.0164326859735878
GO:0042476	odontogenesis	0.0169746959812294
GO:0030155	regulation of cell adhesion	0.019675277020939
GO:0032403	protein complex binding	0.0209823593345206
GO:0007154	cell communication	0.0219724178169959
GO:0005604	basement membrane	0.0250256412289942
GO:0032501	multicellular organismal process	0.0250256412289942
GO:0009653	anatomical structure morphogenesis	0.0256212059399399
GO:0030017	sarcomere	0.0256212059399399
GO:0044449	contractile fiber part	0.0262944639637175
GO:0030016	myofibril	0.0280613268978502
GO:0043292	contractile fiber	0.0283010912373617
GO:0048513	organ development	0.0326411658096284
GO:0044420	extracellular matrix part	0.0326411658096284
GO:0007519	skeletal muscle development	0.033138335906351
GO:0005515	protein binding	0.0369853357259542
GO:0014706	striated muscle development	0.0411228079628484
GO:0009897	external side of plasma membrane	0.0450794982652343
GO:0048731	system development	0.0451373732717434
GO:0005792	microsome	0.049108109726202
GO:0042598	vesicular fraction	0.0496175611299744

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}