MCL coexpression mm9:2917

Phase1 CAGE Peaks

	Short description
Mm9::chr14:56197281..56197376,+	p1@Psme1
Mm9::chr14:56209755..56209806,-	p1@Psme2
Mm9::chr8:108461946..108462034,-	p1@Psmb10

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008538	proteasome activator activity	1.26963764080105e-06
GO:0008537	proteasome activator complex	1.26963764080105e-06
GO:0019884	antigen processing and presentation of exogenous antigen	7.13296994123463e-05
GO:0005829	cytosol	7.33027846218437e-05
GO:0019882	antigen processing and presentation	0.000269645944078079
GO:0044445	cytosolic part	0.000614570947289921
GO:0008047	enzyme activator activity	0.00243690941384157
GO:0043234	protein complex	0.00364705363700122
GO:0032991	macromolecular complex	0.00648665598134676
GO:0005839	proteasome core complex (sensu Eukaryota)	0.0146625694870512
GO:0004298	threonine endopeptidase activity	0.0147311104524437
GO:0002376	immune system process	0.0157733780691099
GO:0000502	proteasome complex (sensu Eukaryota)	0.0157733780691099
GO:0044444	cytoplasmic part	0.0157733780691099

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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