MCL coexpression mm9:2350

Phase1 CAGE Peaks

	Short description
Mm9::chr2:74543872..74543890,-	p@chr2:74543872..74543890 -
Mm9::chr2:74549915..74549930,+	p6@Hoxd3
Mm9::chr2:74549945..74549965,+	p4@Hoxd3
Mm9::chr2:74550178..74550214,+	p5@Hoxd3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007389	pattern specification process	0.0081875859145349
GO:0005667	transcription factor complex	0.0081875859145349
GO:0043565	sequence-specific DNA binding	0.0081875859145349
GO:0009887	organ morphogenesis	0.0081875859145349
GO:0044451	nucleoplasm part	0.0081875859145349
GO:0005654	nucleoplasm	0.0081875859145349
GO:0030878	thyroid gland development	0.00860702973948846
GO:0031981	nuclear lumen	0.00867856041821122
GO:0031974	membrane-enclosed lumen	0.00883377703837142
GO:0043233	organelle lumen	0.00883377703837142
GO:0003700	transcription factor activity	0.00968939998983532
GO:0044428	nuclear part	0.0130111545252997
GO:0009653	anatomical structure morphogenesis	0.0156043588751578
GO:0048513	organ development	0.0192596718015089
GO:0035270	endocrine system development	0.0192596718015089
GO:0043234	protein complex	0.0235490566303766
GO:0048731	system development	0.0235490566303766
GO:0048732	gland development	0.0235490566303766
GO:0006355	regulation of transcription, DNA-dependent	0.0235490566303766
GO:0006351	transcription, DNA-dependent	0.0235490566303766
GO:0032774	RNA biosynthetic process	0.0235490566303766
GO:0003677	DNA binding	0.0235490566303766
GO:0045449	regulation of transcription	0.0235490566303766
GO:0048856	anatomical structure development	0.0235490566303766
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0235490566303766
GO:0006350	transcription	0.0235490566303766
GO:0032991	macromolecular complex	0.0235490566303766
GO:0010468	regulation of gene expression	0.0235959261662096
GO:0031323	regulation of cellular metabolic process	0.0246882310297342
GO:0007275	multicellular organismal development	0.0248349148472164
GO:0019222	regulation of metabolic process	0.0248349148472164
GO:0016070	RNA metabolic process	0.0253456507631269
GO:0044446	intracellular organelle part	0.0255631967120911
GO:0044422	organelle part	0.0255631967120911
GO:0010467	gene expression	0.033186442598594
GO:0003676	nucleic acid binding	0.0338403525474753
GO:0032502	developmental process	0.035068513611556
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0372330122993926
GO:0050794	regulation of cellular process	0.041722885145668

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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