MCL coexpression mm9:73
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0000267 | cell fraction | 0.00123843901423085 |
| GO:0005792 | microsome | 0.00123843901423085 |
| GO:0016491 | oxidoreductase activity | 0.00123843901423085 |
| GO:0042598 | vesicular fraction | 0.00123843901423085 |
| GO:0005624 | membrane fraction | 0.0016548405676883 |
| GO:0006118 | electron transport | 0.00191574530361692 |
| GO:0005783 | endoplasmic reticulum | 0.00220420939280607 |
| GO:0004497 | monooxygenase activity | 0.00387858162515104 |
| GO:0004769 | steroid delta-isomerase activity | 0.00387858162515104 |
| GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity | 0.00387858162515104 |
| GO:0006091 | generation of precursor metabolites and energy | 0.00451027381529529 |
| GO:0015711 | organic anion transport | 0.00632526225768357 |
| GO:0006790 | sulfur metabolic process | 0.00633477916134919 |
| GO:0005506 | iron ion binding | 0.00691439762681614 |
| GO:0006694 | steroid biosynthetic process | 0.00781990092403807 |
| GO:0006700 | C21-steroid hormone biosynthetic process | 0.00781990092403807 |
| GO:0044255 | cellular lipid metabolic process | 0.00914346326497351 |
| GO:0003995 | acyl-CoA dehydrogenase activity | 0.00914346326497351 |
| GO:0008207 | C21-steroid hormone metabolic process | 0.00931476838930189 |
| GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds | 0.00931476838930189 |
| GO:0006749 | glutathione metabolic process | 0.0111266001023922 |
| GO:0016229 | steroid dehydrogenase activity | 0.0130108312137671 |
| GO:0006629 | lipid metabolic process | 0.0141602361023742 |
| GO:0004364 | glutathione transferase activity | 0.0143331195491712 |
| GO:0008610 | lipid biosynthetic process | 0.0171158909181702 |
| GO:0020037 | heme binding | 0.0184537057296516 |
| GO:0046906 | tetrapyrrole binding | 0.0184537057296516 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.0196694804704447 |
| GO:0015938 | coenzyme A catabolic process | 0.0196694804704447 |
| GO:0033783 | 25-hydroxycholesterol 7alpha-hydroxylase activity | 0.0196694804704447 |
| GO:0004361 | glutaryl-CoA dehydrogenase activity | 0.0196694804704447 |
| GO:0004782 | sulfinoalanine decarboxylase activity | 0.0196694804704447 |
| GO:0033791 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity | 0.0196694804704447 |
| GO:0032311 | angiogenin-PRI complex | 0.0196694804704447 |
| GO:0004462 | lactoylglutathione lyase activity | 0.0196694804704447 |
| GO:0017129 | triglyceride binding | 0.0196694804704447 |
| GO:0016206 | catechol O-methyltransferase activity | 0.0196694804704447 |
| GO:0042446 | hormone biosynthetic process | 0.0221816626558905 |
| GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 0.0240576253377109 |
| GO:0008202 | steroid metabolic process | 0.0241700911700084 |
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | 0.0278889318941362 |
| GO:0016860 | intramolecular oxidoreductase activity | 0.0279643458264173 |
| GO:0005319 | lipid transporter activity | 0.0279643458264173 |
| GO:0006732 | coenzyme metabolic process | 0.0279643458264173 |
| GO:0019448 | L-cysteine catabolic process | 0.0279643458264173 |
| GO:0019452 | L-cysteine catabolic process to taurine | 0.0279643458264173 |
| GO:0003986 | acetyl-CoA hydrolase activity | 0.0279643458264173 |
| GO:0004027 | alcohol sulfotransferase activity | 0.0279643458264173 |
| GO:0019530 | taurine metabolic process | 0.0279643458264173 |
| GO:0009093 | cysteine catabolic process | 0.0279643458264173 |
| GO:0046439 | L-cysteine metabolic process | 0.0279643458264173 |
| GO:0008396 | oxysterol 7-alpha-hydroxylase activity | 0.0279643458264173 |
| GO:0048037 | cofactor binding | 0.0304646446675892 |
| GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups | 0.0322101795672695 |
| GO:0044270 | nitrogen compound catabolic process | 0.0345893367702975 |
| GO:0009310 | amine catabolic process | 0.0345893367702975 |
| GO:0042157 | lipoprotein metabolic process | 0.0345893367702975 |
| GO:0051186 | cofactor metabolic process | 0.0345893367702975 |
| GO:0044273 | sulfur compound catabolic process | 0.0345893367702975 |
| GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor | 0.0345893367702975 |
| GO:0042159 | lipoprotein catabolic process | 0.0345893367702975 |
| GO:0004031 | aldehyde oxidase activity | 0.0345893367702975 |
| GO:0000098 | sulfur amino acid catabolic process | 0.0345893367702975 |
| GO:0050660 | FAD binding | 0.0347663221060114 |
| GO:0042424 | catecholamine catabolic process | 0.0426870598999632 |
| GO:0042420 | dopamine catabolic process | 0.0426870598999632 |
| GO:0006699 | bile acid biosynthetic process | 0.0426870598999632 |
| GO:0003997 | acyl-CoA oxidase activity | 0.0426870598999632 |
| GO:0044248 | cellular catabolic process | 0.0440448935352399 |
| GO:0032787 | monocarboxylic acid metabolic process | 0.0444189652925453 |
| GO:0016053 | organic acid biosynthetic process | 0.0460141349508295 |
| GO:0046394 | carboxylic acid biosynthetic process | 0.0460141349508295 |
| GO:0006869 | lipid transport | 0.0465957595265489 |
| GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | 0.0476963703080677 |
| GO:0006534 | cysteine metabolic process | 0.0476963703080677 |
| GO:0005743 | mitochondrial inner membrane | 0.049164284230753 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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