Coexpression cluster:C788

Full id: C788_umbilical_aorta_smooth_bladder_penis_colon_heart

Phase1 CAGE Peaks

Hg19::chr10:90694948..90695025,-	p@chr10:90694948..90695025 -
Hg19::chr10:90713570..90713574,+	p@chr10:90713570..90713574 +
Hg19::chr10:97181754..97181768,-	p14@SORBS1
Hg19::chr13:111164792..111164826,+	p@chr13:111164792..111164826 +
Hg19::chr1:10683041..10683058,+	p@chr1:10683041..10683058 +
Hg19::chr3:78684991..78684993,-	p@chr3:78684991..78684993 -
Hg19::chr4:186578715..186578746,-	p27@SORBS2
Hg19::chr5:156810234..156810257,+	p4@CYFIP2
Hg19::chr5:169805660..169805676,-	p@chr5:169805660..169805676 -
Hg19::chr9:127270402..127270409,-	p@chr9:127270402..127270409 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005915	zonula adherens	0.0139351277842367
GO:0030054	cell junction	0.0139351277842367
GO:0043149	stress fiber formation	0.0139351277842367
GO:0001725	stress fiber	0.0139351277842367
GO:0032432	actin filament bundle	0.0139351277842367
GO:0048041	focal adhesion formation	0.0139351277842367
GO:0005913	cell-cell adherens junction	0.0139351277842367
GO:0051017	actin filament bundle formation	0.0159985789095684
GO:0005158	insulin receptor binding	0.0159985789095684
GO:0022610	biological adhesion	0.0159985789095684
GO:0007155	cell adhesion	0.0159985789095684
GO:0015758	glucose transport	0.0159985789095684
GO:0008645	hexose transport	0.0159985789095684
GO:0008286	insulin receptor signaling pathway	0.0159985789095684
GO:0015749	monosaccharide transport	0.0159985789095684
GO:0019717	synaptosome	0.0161784847753573
GO:0005924	cell-substrate adherens junction	0.0161784847753573
GO:0030055	cell-matrix junction	0.0161784847753573
GO:0007015	actin filament organization	0.0161784847753573
GO:0045121	lipid raft	0.017241358258977
GO:0005912	adherens junction	0.0192715116061175
GO:0048471	perinuclear region of cytoplasm	0.0217956935098357
GO:0016323	basolateral plasma membrane	0.0276716988629033
GO:0007160	cell-matrix adhesion	0.0280620941312236
GO:0032403	protein complex binding	0.0280620941312236
GO:0031589	cell-substrate adhesion	0.0280620941312236
GO:0043296	apical junction complex	0.0280620941312236
GO:0016327	apicolateral plasma membrane	0.0280620941312236
GO:0008643	carbohydrate transport	0.0286376253616859
GO:0044459	plasma membrane part	0.0367167446690375
GO:0005911	intercellular junction	0.0416776000298609
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0489568766360709

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
adult organism	2.08e-24	115
anatomical conduit	1.20e-10	241
anatomical cluster	2.04e-10	286
central nervous system	2.16e-10	82
multi-cellular organism	2.99e-10	659
regional part of nervous system	1.39e-09	94
nervous system	1.39e-09	94
neural tube	1.55e-09	57
neural rod	1.55e-09	57
future spinal cord	1.55e-09	57
neural keel	1.55e-09	57
tube	2.04e-09	194
regional part of brain	2.95e-09	59
brain	1.12e-08	69
future brain	1.12e-08	69
organism subdivision	5.59e-08	365
neural plate	7.93e-08	86
presumptive neural plate	7.93e-08	86
anterior neural tube	1.09e-07	42
neurectoderm	1.30e-07	90
regional part of forebrain	2.56e-07	41
forebrain	2.56e-07	41
future forebrain	2.56e-07	41
multi-tissue structure	4.26e-07	347
telencephalon	6.38e-07	34
regional part of telencephalon	7.37e-07	33
gray matter	7.61e-07	34
brain grey matter	7.61e-07	34
anatomical system	8.01e-07	625

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.