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Coexpression cluster:C314

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Full id: C314_Macrophage_Dendritic_Monocytederived_CD14_Esophageal_Mast_Keratinocyte



Phase1 CAGE Peaks

Hg19::chr10:49893321..49893329,+p8@WDFY4
Hg19::chr11:72431299..72431322,-p@chr11:72431299..72431322
-
Hg19::chr12:65153154..65153171,-p2@GNS
Hg19::chr12:9102224..9102270,-p1@M6PR
Hg19::chr14:61449197..61449207,+p15@SLC38A6
Hg19::chr15:78351618..78351622,-p@chr15:78351618..78351622
-
Hg19::chr17:46022728..46022773,+p@chr17:46022728..46022773
+
Hg19::chr17:7483714..7483726,+p@chr17:7483714..7483726
+
Hg19::chr17:7483994..7484032,+p@chr17:7483994..7484032
+
Hg19::chr17:7484124..7484142,+p@chr17:7484124..7484142
+
Hg19::chr17:78180739..78180750,+p2@AK095416
Hg19::chr17:78180789..78180807,+p1@AK095416
Hg19::chr17:78193607..78193642,+p@chr17:78193607..78193642
+
Hg19::chr17:78194046..78194081,+p2@SLC26A11
Hg19::chr18:9772139..9772150,+p@chr18:9772139..9772150
+
Hg19::chr19:11689752..11689799,-p2@ACP5
Hg19::chr19:11689803..11689815,-p5@ACP5
Hg19::chr1:159796480..159796494,+p5@SLAMF8
Hg19::chr1:46016762..46016777,+p3@AKR1A1
Hg19::chr20:1875058..1875060,+p21@SIRPA
Hg19::chr20:39518079..39518082,-p@chr20:39518079..39518082
-
Hg19::chr20:57582296..57582325,-p1@CTSZ
Hg19::chr3:69591495..69591521,-p7@FRMD4B
Hg19::chr5:131280548..131280574,-p1@ENST00000425320
Hg19::chr5:131280595..131280605,-p2@ENST00000425320
Hg19::chr5:150632732..150632758,+p1@GM2A
Hg19::chr6:134758827..134758863,+p1@LOC154092
Hg19::chr6:160406578..160406590,+p@chr6:160406578..160406590
+
Hg19::chr6:36097945..36097981,+p3@MAPK13
Hg19::chr6:36097992..36098038,+p4@MAPK13
Hg19::chr6:46703069..46703081,-p2@PLA2G7
Hg19::chr6:46703092..46703156,-p1@PLA2G7
Hg19::chr6:46703447..46703465,-p3@PLA2G7
Hg19::chr6:6799417..6799457,-p@chr6:6799417..6799457
-
Hg19::chr6:6801396..6801410,-p@chr6:6801396..6801410
-
Hg19::chr8:132916703..132916721,+p@chr8:132916703..132916721
+
Hg19::chr8:66891425..66891440,+p@chr8:66891425..66891440
+
Hg19::chr9:127023704..127023756,+p3@NEK6


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


p.valueFDRnGenesnPathwayName
5.2977040485515e-093.3534466627331e-065121Lysosome (KEGG):04142
4.72529853545926e-050.009970379909819033128Osteoclast differentiation (KEGG):04380
2.61528773412653e-050.008277385678510463105Membrane Trafficking (Reactome):REACT_11123
0.0003004892772442460.047552428123902246Interactions of the immunoglobulin superfamily (IgSF) member proteins (Reactome):REACT_23853



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005764lysosome4.52582062239315e-06
GO:0000323lytic vacuole4.52582062239315e-06
GO:0005773vacuole6.15010206948201e-06
GO:0030290sphingolipid activator protein activity0.012127634522548
GO:0032428beta-N-acetylgalactosaminidase activity0.012127634522548
GO:0047939L-glucuronate reductase activity0.012127634522548
GO:0046185aldehyde catabolic process0.012127634522548
GO:0042839D-glucuronate metabolic process0.012127634522548
GO:0042840D-glucuronate catabolic process0.012127634522548
GO:0008449N-acetylglucosamine-6-sulfatase activity0.012127634522548
GO:0019853L-ascorbic acid biosynthetic process0.012127634522548
GO:0006064glucuronate catabolic process0.012127634522548
GO:0007243protein kinase cascade0.0132272258457848
GO:0045177apical part of cell0.0132272258457848
GO:0009056catabolic process0.0132272258457848
GO:0005889hydrogen:potassium-exchanging ATPase complex0.0132272258457848
GO:0015761mannose transport0.0132272258457848
GO:0008106alcohol dehydrogenase (NADP+) activity0.0132272258457848
GO:0015578mannose transmembrane transporter activity0.0132272258457848
GO:0016004phospholipase activator activity0.0132272258457848
GO:0045179apical cortex0.0132272258457848
GO:0009313oligosaccharide catabolic process0.0132272258457848
GO:0008339MP kinase activity0.0161630403516077
GO:0004032aldehyde reductase activity0.0161630403516077
GO:0006063uronic acid metabolic process0.0161630403516077
GO:0019852L-ascorbic acid metabolic process0.0161630403516077
GO:0019585glucuronate metabolic process0.0161630403516077
GO:0004563beta-N-acetylhexosaminidase activity0.0191472672715482
GO:00082472-acetyl-1-alkylglycerophosphocholine esterase complex0.0191472672715482
GO:0006689ganglioside catabolic process0.0191472672715482
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0191472672715482
GO:0016042lipid catabolic process0.0204320329707988
GO:0046479glycosphingolipid catabolic process0.021805657903249
GO:0008333endosome to lysosome transport0.021805657903249
GO:0006026aminoglycan catabolic process0.021805657903249
GO:0016909SAP kinase activity0.021805657903249
GO:0050700CARD domain binding0.021805657903249
GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activity0.021805657903249
GO:0006027glycosaminoglycan catabolic process0.021805657903249
GO:0009898internal side of plasma membrane0.021805657903249
GO:0005737cytoplasm0.0226485989309556
GO:0019377glycolipid catabolic process0.0242231611391587
GO:0019915sequestering of lipid0.0260623078098239
GO:0001573ganglioside metabolic process0.0260623078098239
GO:0044425membrane part0.0260623078098239
GO:0016054organic acid catabolic process0.0309027153522172
GO:0046395carboxylic acid catabolic process0.0309027153522172
GO:0016020membrane0.0322521867971921
GO:0030071regulation of mitotic metaphase/anaphase transition0.0325983230004245
GO:0004033aldo-keto reductase activity0.0328706422062493
GO:0005537mannose binding0.0328706422062493
GO:0007091mitotic metaphase/anaphase transition0.0328706422062493
GO:0007250activation of NF-kappaB-inducing kinase0.0328706422062493
GO:0005975carbohydrate metabolic process0.0331554372984391
GO:0044248cellular catabolic process0.033577971469853
GO:0043085positive regulation of catalytic activity0.0349332211990327
GO:0007041lysosomal transport0.0356421855368791
GO:0030149sphingolipid catabolic process0.0375213613292531
GO:0048029monosaccharide binding0.0410886012693866
GO:0015929hexosaminidase activity0.0410886012693866
GO:0050885neuromuscular process controlling balance0.0427829322362058
GO:0006687glycosphingolipid metabolic process0.0444215781542066



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.01e-35112
hematopoietic system6.45e-34102
blood island6.45e-34102
bone marrow7.00e-3080
lateral plate mesoderm1.39e-27216
immune system5.13e-27115
bone element6.24e-2486
skeletal element1.09e-20101
skeletal system1.09e-20101
mesoderm8.14e-12448
mesoderm-derived structure8.14e-12448
presumptive mesoderm8.14e-12448
musculoskeletal system1.27e-11167
anatomical group3.32e-10626
anatomical system4.48e-10625
embryonic structure1.34e-07605
developing anatomical structure1.34e-07605
organ1.43e-07511
germ layer1.67e-07604
embryonic tissue1.67e-07604
presumptive structure1.67e-07604
epiblast (generic)1.67e-07604
multi-cellular organism2.15e-07659
embryo4.64e-07612


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.