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Coexpression cluster:C123

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Full id: C123_CD19_Natural_CD8_CD4_CD14_Peripheral_Basophils



Phase1 CAGE Peaks

Hg19::chr10:12392687..12392699,-p@chr10:12392687..12392699
-
Hg19::chr10:126432640..126432663,-p4@FAM53B
Hg19::chr10:126432670..126432723,-p3@FAM53B
Hg19::chr10:15139614..15139671,-p1@C10orf111
Hg19::chr10:5727231..5727239,-p1@AK126513
Hg19::chr11:113185382..113185393,+p3@TTC12
Hg19::chr11:46639436..46639466,-p2@HARBI1
Hg19::chr11:57509422..57509437,-p@chr11:57509422..57509437
-
Hg19::chr11:58345505..58345516,-p9@LPXN
Hg19::chr11:59437000..59437035,-p5@PATL1
Hg19::chr11:62319223..62319248,-p@chr11:62319223..62319248
-
Hg19::chr11:64052561..64052571,-p12@BAD
Hg19::chr11:69065734..69065737,+p@chr11:69065734..69065737
+
Hg19::chr12:106695911..106695928,+p@chr12:106695911..106695928
+
Hg19::chr12:106695930..106695942,+p@chr12:106695930..106695942
+
Hg19::chr12:106695946..106695967,+p@chr12:106695946..106695967
+
Hg19::chr12:12510212..12510225,+p6@LOH12CR1
Hg19::chr12:12510241..12510263,+p4@LOH12CR1
Hg19::chr12:25538611..25538629,+p@chr12:25538611..25538629
+
Hg19::chr12:25538639..25538657,+p@chr12:25538639..25538657
+
Hg19::chr12:50135975..50135991,-p@chr12:50135975..50135991
-
Hg19::chr12:65563183..65563201,-p@chr12:65563183..65563201
-
Hg19::chr12:794806..794815,+p@chr12:794806..794815
+
Hg19::chr13:28195482..28195491,-p4@LNX2
Hg19::chr13:37575209..37575223,-p@chr13:37575209..37575223
-
Hg19::chr13:52026813..52026829,-p4@INTS6
Hg19::chr13:98087050..98087059,-p@chr13:98087050..98087059
-
Hg19::chr14:52314077..52314088,-p@chr14:52314077..52314088
-
Hg19::chr14:55518677..55518700,-p@chr14:55518677..55518700
-
Hg19::chr14:55518707..55518734,-p@chr14:55518707..55518734
-
Hg19::chr14:64971288..64971316,-p2@ZBTB25
Hg19::chr14:64971346..64971357,-p9@ZBTB25
Hg19::chr14:64971893..64971928,-p8@ZBTB25
Hg19::chr14:75642741..75642766,+p@chr14:75642741..75642766
+
Hg19::chr14:75642917..75642942,+p@chr14:75642917..75642942
+
Hg19::chr14:90849734..90849772,+p2@BC039305
Hg19::chr14:94547495..94547508,-p2@DDX24
Hg19::chr15:50978554..50978560,+p@chr15:50978554..50978560
+
Hg19::chr15:52471696..52471707,+p@chr15:52471696..52471707
+
Hg19::chr15:72767490..72767526,-p1@AK026340
Hg19::chr15:83478370..83478426,+p1@WHAMM
Hg19::chr15:83478446..83478468,+p2@WHAMM
Hg19::chr15:90809334..90809354,+p7@NGRN
Hg19::chr16:2041391..2041393,+p@chr16:2041391..2041393
+
Hg19::chr16:68298781..68298792,-p@chr16:68298781..68298792
-
Hg19::chr17:38717290..38717301,+p@chr17:38717290..38717301
+
Hg19::chr17:38717306..38717321,+p@chr17:38717306..38717321
+
Hg19::chr17:41322948..41322969,-p@chr17:41322948..41322969
-
Hg19::chr17:79819420..79819433,-p@chr17:79819420..79819433
-
Hg19::chr17:80255928..80255943,-p@chr17:80255928..80255943
-
Hg19::chr17:80255969..80255980,-p@chr17:80255969..80255980
-
Hg19::chr18:11851018..11851036,+p7@CHMP1B
Hg19::chr18:71815135..71815173,+p@chr18:71815135..71815173
+
Hg19::chr19:10341278..10341304,+p@chr19:10341278..10341304
+
Hg19::chr19:10347101..10347110,+p@chr19:10347101..10347110
+
Hg19::chr19:10347111..10347120,+p@chr19:10347111..10347120
+
Hg19::chr19:14486179..14486197,+p@chr19:14486179..14486197
+
Hg19::chr19:37095638..37095647,-p@chr19:37095638..37095647
-
Hg19::chr19:37095841..37095855,+p2@ZNF382
Hg19::chr19:39881431..39881443,+p@chr19:39881431..39881443
+
Hg19::chr19:40790530..40790546,+p@chr19:40790530..40790546
+
Hg19::chr19:40790569..40790585,+p@chr19:40790569..40790585
+
Hg19::chr1:112298075..112298090,-p3@FAM212B
Hg19::chr1:115054310..115054326,+p@chr1:115054310..115054326
+
Hg19::chr1:14029343..14029381,-p@chr1:14029343..14029381
-
Hg19::chr1:14076759..14076771,+p@chr1:14076759..14076771
+
Hg19::chr1:153606799..153606818,-p8@S100A13
Hg19::chr1:156066892..156066941,-p@chr1:156066892..156066941
-
Hg19::chr1:156067106..156067143,+p1@AK123652
Hg19::chr1:171455154..171455177,-p2@BC007549
Hg19::chr1:186344666..186344694,+p4@C1orf27
Hg19::chr1:22109734..22109790,+p@chr1:22109734..22109790
+
Hg19::chr1:2232091..2232125,+p@chr1:2232091..2232125
+
Hg19::chr1:22352338..22352353,-p@chr1:22352338..22352353
-
Hg19::chr1:228327553..228327587,-p@chr1:228327553..228327587
-
Hg19::chr1:234744958..234745002,-p8@IRF2BP2
Hg19::chr1:234745050..234745097,-p1@IRF2BP2
Hg19::chr1:236959047..236959062,-p@chr1:236959047..236959062
-
Hg19::chr20:23330784..23330836,+p@chr20:23330784..23330836
+
Hg19::chr20:43992000..43992015,-p@chr20:43992000..43992015
-
Hg19::chr20:5591145..5591173,+p@chr20:5591145..5591173
+
Hg19::chr21:30398882..30398888,+p@chr21:30398882..30398888
+
Hg19::chr21:43640357..43640399,-p@chr21:43640357..43640399
-
Hg19::chr22:39097378..39097392,-p10@JOSD1
Hg19::chr22:39097393..39097425,-p7@JOSD1
Hg19::chr22:42336157..42336166,-p8@CENPM
Hg19::chr22:42336209..42336228,-p3@CENPM
Hg19::chr22:50629950..50629967,-p@chr22:50629950..50629967
-
Hg19::chr2:113033704..113033722,-p@chr2:113033704..113033722
-
Hg19::chr2:122406191..122406211,+p@chr2:122406191..122406211
+
Hg19::chr2:201828138..201828160,+p1@ENST00000332935
Hg19::chr2:202123105..202123116,-p@chr2:202123105..202123116
-
Hg19::chr2:220144408..220144433,-p@chr2:220144408..220144433
-
Hg19::chr2:232574974..232574995,-p@chr2:232574974..232574995
-
Hg19::chr2:27435537..27435561,-p7@SLC5A6
Hg19::chr2:27435611..27435624,-p8@SLC5A6
Hg19::chr2:27435634..27435665,-p6@SLC5A6
Hg19::chr2:86790191..86790209,+p@chr2:86790191..86790209
+
Hg19::chr3:107810152..107810193,+p@chr3:107810152..107810193
+
Hg19::chr3:13522103..13522125,-p@chr3:13522103..13522125
-
Hg19::chr3:135914615..135914701,-p3@MSL2
Hg19::chr3:14693622..14693632,-p@chr3:14693622..14693632
-
Hg19::chr3:179041570..179041596,-p@chr3:179041570..179041596
-
Hg19::chr3:179041606..179041620,-p@chr3:179041606..179041620
-
Hg19::chr3:179041625..179041643,-p@chr3:179041625..179041643
-
Hg19::chr3:23986876..23986885,+p4@NR1D2
Hg19::chr3:71114290..71114305,+p@chr3:71114290..71114305
+
Hg19::chr3:71115673..71115676,+p@chr3:71115673..71115676
+
Hg19::chr4:149363856..149363872,+p@chr4:149363856..149363872
+
Hg19::chr4:149364278..149364307,-p@chr4:149364278..149364307
-
Hg19::chr4:26862558..26862576,+p1@STIM2
Hg19::chr4:26863338..26863342,+p@chr4:26863338..26863342
+
Hg19::chr4:76598867..76598882,+p@chr4:76598867..76598882
+
Hg19::chr4:78783782..78783819,-p@chr4:78783782..78783819
-
Hg19::chr5:179248528..179248568,-p@chr5:179248528..179248568
-
Hg19::chr5:32312391..32312420,+p@chr5:32312391..32312420
+
Hg19::chr5:34839130..34839157,-p@chr5:34839130..34839157
-
Hg19::chr5:54603850..54603853,+p5@SKIV2L2
Hg19::chr5:98265261..98265280,-p@chr5:98265261..98265280
-
Hg19::chr6:109762344..109762356,-p5@PPIL6
Hg19::chr6:119216251..119216300,-p@chr6:119216251..119216300
-
Hg19::chr6:136610575..136610598,+p@chr6:136610575..136610598
+
Hg19::chr6:159239993..159240009,+p@chr6:159239993..159240009
+
Hg19::chr6:159290473..159290489,-p@chr6:159290473..159290489
-
Hg19::chr6:159290503..159290512,-p@chr6:159290503..159290512
-
Hg19::chr6:26285546..26285558,+p@chr6:26285546..26285558
+
Hg19::chr6:28048860..28048889,-p2@uc003nkf.2
Hg19::chr6:292408..292424,-p@chr6:292408..292424
-
Hg19::chr6:32941036..32941050,-p@chr6:32941036..32941050
-
Hg19::chr6:4021464..4021476,+p6@PRPF4B
Hg19::chr6:7389966..7389993,-p1@CAGE1
Hg19::chr6:87864744..87864763,+p@chr6:87864744..87864763
+
Hg19::chr7:108209925..108209941,-p2@THAP5
Hg19::chr7:130792816..130792827,-p2@ENST00000423414
Hg19::chr7:140714541..140714552,+p@chr7:140714541..140714552
+
Hg19::chr7:2550533..2550560,-p@chr7:2550533..2550560
-
Hg19::chr7:35840534..35840564,-p2@ENST00000424194
Hg19::chr8:104427080..104427102,+p3@DCAF13
Hg19::chr8:81398511..81398523,+p8@ZBTB10
Hg19::chr8:81398538..81398549,+p14@ZBTB10
Hg19::chr8:81398552..81398563,+p13@ZBTB10
Hg19::chr9:102583633..102583644,+p8@NR4A3
Hg19::chr9:102669358..102669378,-p1@LOC441461
Hg19::chr9:132769827..132769840,-p@chr9:132769827..132769840
-
Hg19::chrX:110924483..110924500,+p2@ALG13
Hg19::chrX:17755245..17755252,+p6@SCML1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0043231intracellular membrane-bound organelle0.0226705607721863
GO:0043227membrane-bound organelle0.0226705607721863
GO:0032235negative regulation of calcium ion transport via store-operated calcium channel0.0400800066572294
GO:0004577N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity0.0400800066572294
GO:0016070RNA metabolic process0.0400800066572294
GO:0005634nucleus0.0460791453004554
GO:0032234regulation of calcium ion transport via store-operated calcium channel0.0460791453004554
GO:0008523sodium-dependent multivitamin transmembrane transporter activity0.0460791453004554
GO:0043169cation binding0.0495674418916741



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte2.66e-53140
hematopoietic stem cell4.78e-48172
angioblastic mesenchymal cell4.78e-48172
hematopoietic cell5.85e-44182
hematopoietic oligopotent progenitor cell1.08e-43165
hematopoietic multipotent progenitor cell1.08e-43165
hematopoietic lineage restricted progenitor cell6.31e-42124
nongranular leukocyte2.01e-41119
lymphocyte4.62e-2553
common lymphoid progenitor4.62e-2553
lymphoid lineage restricted progenitor cell7.34e-2552
CD14-positive, CD16-negative classical monocyte1.89e-2142
classical monocyte4.03e-2145
myeloid leukocyte5.20e-2176
myeloid cell4.18e-19112
common myeloid progenitor4.18e-19112
granulocyte monocyte progenitor cell2.90e-1871
myeloid lineage restricted progenitor cell3.14e-1670
macrophage dendritic cell progenitor5.99e-1665
monopoietic cell6.41e-1563
monocyte6.41e-1563
monoblast6.41e-1563
promonocyte6.41e-1563
T cell4.75e-1225
pro-T cell4.75e-1225
lymphocyte of B lineage5.24e-1224
pro-B cell5.24e-1224
mature alpha-beta T cell5.32e-1118
alpha-beta T cell5.32e-1118
immature T cell5.32e-1118
mature T cell5.32e-1118
immature alpha-beta T cell5.32e-1118
B cell8.73e-0914
CD8-positive, alpha-beta T cell5.79e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.65e-22102
blood island3.65e-22102
hemolymphoid system9.22e-20112
bone marrow8.94e-1580
bone element1.06e-1386
immune system6.29e-12115
adult organism1.50e-11115
skeletal element3.51e-08101
skeletal system3.51e-08101
blood9.74e-0715
haemolymphatic fluid9.74e-0715
organism substance9.74e-0715


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538142.335679623919530.002878682140648490.0155751273940417
BCL11A#53335214.080538062847595.2511043391141e-083.34402491507766e-06
BCLAF1#9774213.114421916524374.03512786888394e-060.000130230135815318
CCNT2#905532.300127969719311.25938978273084e-091.14472941269475e-07
CEBPB#1051382.074682258776327.83768942036453e-060.000222193389080741
CHD2#1106312.196333615463172.27398166442848e-050.000496638166146478
CTCF#10664391.431849305136480.01052974619356330.0389638663091538
CTCFL#140690152.028747365648050.007423901148749450.0306593701638753
E2F1#1869782.621755881921831.24781699294015e-182.87050129792238e-16
E2F4#1874262.25595594655757.61611626945388e-050.00117543899374242
E2F6#1876702.405485624786422.93846425287787e-144.87127409692558e-12
EBF1#1879533.233169471699712.09625720323142e-153.82078544586887e-13
EGR1#1958612.084102224543961.79297147894818e-091.55657646126242e-07
ELF1#1997782.274874251965675.7152335289359e-151.001498782766e-12
ELK4#2005182.001659382550850.003928365679392650.0191395121846468
EP300#2033371.716683862125060.0005662387943254660.00482951518501897
ETS1#2113312.065695812248447.2766760312596e-050.00114298205448747
FOSL1#8061102.720108199751580.004066890664794510.0194532378006996
FOXA1#3169251.897503381744080.001384524142436460.00901204842081155
FOXA2#3170142.361825291351460.002605638276908640.0144075739094696
GABPB1#2553492.372030876526892.62131201059841e-092.20780004092651e-07
GATA1#2623282.60060704127682.80000313384948e-069.68309693033463e-05
GATA2#2624282.444233483147348.99674239533548e-060.000242167726553207
GTF2F1#2962292.53048058510943.07508476512804e-060.0001036664873419
HEY1#23462812.241431469120292.30184521165727e-154.17365298715753e-13
HMGN3#9324452.52078525719712.37147513154205e-092.01853701110938e-07
IRF1#3659351.830826927224220.0002512526594229610.00270660923130218
IRF4#3662172.551689833388020.0003858212139473980.00377751774289418
JUND#3727361.724711656899710.0006302923747916220.00518323664022537
MAX#4149492.165583698228425.16774763445849e-083.2969724813391e-06
MEF2A#4205283.59459222924683.70005731333055e-093.04036416795381e-07
MEF2C#4208123.395453793914310.0002469990741823890.00268516043598777
MXI1#4601362.456277935858462.95617199405092e-071.49510724884593e-05
MYC#4609642.289219450568518.30237102636846e-121.0434312005089e-09
NFKB1#4790732.744031712096923.19606815824649e-187.16296485792071e-16
NRF1#4899211.756273071246090.008209660282979380.0324051819907813
PAX5#5079652.969327120044921.57737195449797e-173.33480059829582e-15
PBX3#5090243.602385647136025.45001790452392e-083.44757371248076e-06
POLR2A#54301372.015075925948337.75923204418568e-353.78675904421826e-32
POU2F2#5452573.555130625283041.37056967284061e-183.1390553960921e-16
REST#5978312.048978699999798.45781696355461e-050.00126878188143735
RFX5#5993211.732918680623950.00947988673547170.0357180955577737
SIN3A#25942732.704442363407577.31809245138454e-181.59894196136015e-15
SIRT6#5154855.261589177740580.002808447246561120.0153759395042775
SMARCA4#659766.442434382515950.0003780750412017480.00374912449943689
SMARCB1#6598344.250632442187345.64946383074129e-138.18341682411636e-11
SMARCC1#6599113.289705154218810.0005825874835430680.00488713688303249
SP1#6667602.341800566359272.27376308152793e-112.71704282004228e-09
SPI1#6688492.753505835052151.45592218163785e-111.78678092512427e-09
SREBF1#672082.575662983040450.01330426815193680.0470389810596203
SRF#6722242.268029303370050.0001380630973190090.00180397495569873
STAT1#6772172.411041009947850.0007274123942663630.00580191103137198
STAT2#6773104.470121314139779.43409124546188e-050.0013678842920794
TAF1#68721062.427143193760282.6236204766056e-268.83897738568427e-24
TAF7#6879272.114334752965380.0001594853186791430.00200005850114446
TBP#6908862.183440267741715.6593692866756e-161.08850620429303e-13
TCF12#6938362.622196825196655.88635663866183e-083.66586285620276e-06
TFAP2C#7022261.924931122303880.0008913595599840360.00663573320159475
USF1#7391351.525016950015610.006147831416625260.0271800095382012
USF2#7392232.046716026415070.0008128318377151260.00619373590392018
YY1#7528561.883736725971344.52099889052568e-072.14427158550232e-05
ZBTB7A#51341482.417066073822212.21707365907216e-091.89638784504371e-07
ZEB1#6935343.93292252463354.79674878610386e-126.27779005603886e-10
ZNF143#7702191.756963386933770.01179509707021820.042973143895783
ZNF263#10127553.097269109832793.03058766825208e-155.46652064740205e-13



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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