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Coexpression cluster:C4592

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Full id: C4592_acute_myelodysplastic_CD34_CD133_Hodgkin_chronic_CD14CD16



Phase1 CAGE Peaks

Hg19::chr6:31583761..31583786,+p3@AIF1
Hg19::chr6:31583787..31583826,+p2@AIF1
Hg19::chr6:31583836..31583847,+p7@AIF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell4.65e-73172
angioblastic mesenchymal cell4.65e-73172
hematopoietic oligopotent progenitor cell1.99e-67165
hematopoietic multipotent progenitor cell1.99e-67165
hematopoietic cell1.66e-66182
leukocyte1.97e-51140
myeloid cell8.38e-47112
common myeloid progenitor8.38e-47112
nongranular leukocyte3.48e-44119
hematopoietic lineage restricted progenitor cell1.91e-43124
myeloid leukocyte1.69e-2676
granulocyte monocyte progenitor cell4.18e-2671
macrophage dendritic cell progenitor1.74e-2565
myeloid lineage restricted progenitor cell1.47e-2470
monopoietic cell2.88e-2463
monocyte2.88e-2463
monoblast2.88e-2463
promonocyte2.88e-2463
CD14-positive, CD16-negative classical monocyte5.80e-2342
classical monocyte8.74e-2145
lymphocyte3.56e-1753
common lymphoid progenitor3.56e-1753
lymphoid lineage restricted progenitor cell1.22e-1652
T cell6.19e-1225
pro-T cell6.19e-1225
mature alpha-beta T cell1.61e-1118
alpha-beta T cell1.61e-1118
immature T cell1.61e-1118
mature T cell1.61e-1118
immature alpha-beta T cell1.61e-1118
mesenchymal cell3.56e-09358
connective tissue cell8.96e-09365
CD8-positive, alpha-beta T cell1.43e-0811
intermediate monocyte2.87e-079
CD14-positive, CD16-positive monocyte2.87e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.39e-29102
blood island1.39e-29102
hemolymphoid system2.36e-26112
bone marrow6.08e-2280
bone element1.67e-1886
adult organism4.24e-18115
immune system1.81e-17115
skeletal element2.34e-13101
skeletal system2.34e-13101
neural tube2.00e-0857
neural rod2.00e-0857
future spinal cord2.00e-0857
neural keel2.00e-0857
connective tissue2.16e-08375
anterior neural tube2.19e-0742
regional part of forebrain2.83e-0741
forebrain2.83e-0741
future forebrain2.83e-0741
Disease
Ontology termp-valuen
leukemia2.54e-2139
myeloid leukemia1.29e-1931
hematologic cancer3.50e-1851
immune system cancer3.50e-1851


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.