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Coexpression cluster:C3265

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Full id: C3265_heart_umbilical_left_smooth_globus_Cardiac_neuroblastoma



Phase1 CAGE Peaks

Hg19::chr12:2079855..2079865,+p12@CACNA1C
Hg19::chr1:237207955..237207959,+p@chr1:237207955..237207959
+
Hg19::chr6:129287144..129287148,+p@chr6:129287144..129287148
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism4.47e-44115
neural tube2.77e-2157
neural rod2.77e-2157
future spinal cord2.77e-2157
neural keel2.77e-2157
central nervous system2.77e-2182
regional part of nervous system1.83e-2094
nervous system1.83e-2094
regional part of brain5.67e-2059
anterior neural tube1.30e-1742
neural plate1.90e-1786
presumptive neural plate1.90e-1786
brain5.05e-1769
future brain5.05e-1769
neurectoderm5.08e-1790
regional part of forebrain1.29e-1641
forebrain1.29e-1641
future forebrain1.29e-1641
gray matter6.10e-1534
brain grey matter6.10e-1534
telencephalon1.48e-1434
cerebral hemisphere4.14e-1432
regional part of telencephalon6.12e-1433
regional part of cerebral cortex4.00e-1322
pre-chordal neural plate3.23e-1161
cerebral cortex4.92e-1125
pallium4.92e-1125
neocortex7.48e-1120
ectoderm-derived structure1.74e-09169
ectoderm1.88e-09173
presumptive ectoderm1.88e-09173
anterior region of body1.35e-08129
craniocervical region1.35e-08129
head9.39e-08123
multi-cellular organism2.49e-07659


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.