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MCL coexpression mm9:2860

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Phase1 CAGE Peaks

 Short description
Mm9::chr13:55313414..55313447,+p2@Nsd1
Mm9::chr6:86354251..86354313,+p1@Tia1
Mm9::chr9:56266612..56266654,+p1@Hmg20a


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030331estrogen receptor binding0.00810825617706678
GO:0046966thyroid hormone receptor binding0.00810825617706678
GO:0046975histone lysine N-methyltransferase activity (H3-K36 specific)0.00810825617706678
GO:0016568chromatin modification0.00896215672069559
GO:0035258steroid hormone receptor binding0.00903808206770178
GO:0042974retinoic acid receptor binding0.00903808206770178
GO:0042799histone lysine N-methyltransferase activity (H4-K20 specific)0.00903808206770178
GO:0046965retinoid X receptor binding0.00903808206770178
GO:0006325establishment and/or maintenance of chromatin architecture0.00903808206770178
GO:0017091AU-rich element binding0.00903808206770178
GO:0006323DNA packaging0.00903808206770178
GO:0031324negative regulation of cellular metabolic process0.00933700986064206
GO:0016922ligand-dependent nuclear receptor binding0.00935362998129836
GO:0009892negative regulation of metabolic process0.0102114007393278
GO:0051276chromosome organization and biogenesis0.0114543722633916
GO:0035097histone methyltransferase complex0.0114543722633916
GO:0010468regulation of gene expression0.0114543722633916
GO:0031323regulation of cellular metabolic process0.0122039355836149
GO:0042036negative regulation of cytokine biosynthetic process0.0122478024990145
GO:0019222regulation of metabolic process0.0122478024990145
GO:0035257nuclear hormone receptor binding0.0127345656648945
GO:0051427hormone receptor binding0.0132600607150388
GO:0016571histone methylation0.0158518140714068
GO:0018024histone-lysine N-methyltransferase activity0.0158907178865336
GO:0016278lysine N-methyltransferase activity0.0158907178865336
GO:0016279protein-lysine N-methyltransferase activity0.0158907178865336
GO:0010467gene expression0.0168146204921224
GO:0006259DNA metabolic process0.017233100952645
GO:0042054histone methyltransferase activity0.0198737457423813
GO:0017148negative regulation of translation0.0198737457423813
GO:0031327negative regulation of cellular biosynthetic process0.0198737457423813
GO:0006479protein amino acid methylation0.0198737457423813
GO:0008213protein amino acid alkylation0.0198737457423813
GO:0001702gastrulation with mouth forming second0.0210871265304523
GO:0050794regulation of cellular process0.0210871265304523
GO:0009890negative regulation of biosynthetic process0.0210871265304523
GO:0008170N-methyltransferase activity0.0210871265304523
GO:0008276protein methyltransferase activity0.0210871265304523
GO:0016570histone modification0.0211678896003258
GO:0048523negative regulation of cellular process0.0216028946271842
GO:0016569covalent chromatin modification0.0219083509771772
GO:0048519negative regulation of biological process0.0236369750219196
GO:0043414biopolymer methylation0.0236369750219196
GO:0050789regulation of biological process0.0236369750219196
GO:0032259methylation0.0242661749924914
GO:0042035regulation of cytokine biosynthetic process0.026369046303537
GO:0003714transcription corepressor activity0.0288954535041561
GO:0065007biological regulation0.0289057852480629
GO:0042089cytokine biosynthetic process0.0289057852480629
GO:0042107cytokine metabolic process0.0289057852480629
GO:0005634nucleus0.0289057852480629
GO:0007369gastrulation0.0289057852480629
GO:0006996organelle organization and biogenesis0.0291273914862101
GO:0051248negative regulation of protein metabolic process0.0305188836318489
GO:0008757S-adenosylmethionine-dependent methyltransferase activity0.0308419047956447
GO:0006730one-carbon compound metabolic process0.0333074784707566
GO:0003682chromatin binding0.0412973269226017
GO:0001816cytokine production0.0412973269226017



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
anterior region of body7.44e-0843
multi-cellular organism5.64e-07333


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.10.526413
MA0004.10.801718
MA0006.10.60285
MA0007.10.784593
MA0009.11.27673
MA0014.11.33691
MA0017.10.635031
MA0019.11.08369
MA0024.11.23079
MA0025.11.51835
MA0027.12.9431
MA0028.10.61552
MA0029.11.20789
MA0030.11.21482
MA0031.11.17722
MA0038.10.963265
MA0040.11.28983
MA0041.10.714279
MA0042.10.69885
MA0043.11.3775
MA0046.11.31428
MA0048.10.932001
MA0050.10.845669
MA0051.10.973068
MA0052.11.29825
MA0055.10.190475
MA0056.10
MA0057.11.60767
MA0058.10.690848
MA0059.10.705317
MA0060.10.502699
MA0061.10.5406
MA0063.10
MA0066.10.951196
MA0067.11.63197
MA0068.11.62747
MA0069.11.29861
MA0070.11.28847
MA0071.10.844726
MA0072.11.2796
MA0073.10.680038
MA0074.10.911576
MA0076.10.657929
MA0077.11.2569
MA0078.11.0091
MA0081.10.732313
MA0083.11.37668
MA0084.11.96428
MA0087.11.33189
MA0088.10.766354
MA0089.10
MA0090.10.762482
MA0091.10.816659
MA0092.10.762845
MA0093.10.62555
MA0095.10
MA0098.10
MA0100.10.89873
MA0101.10.71579
MA0103.10.647985
MA0105.10.405648
MA0106.11.01755
MA0107.10.640607
MA0108.21.10817
MA0109.10
MA0111.10.778753
MA0113.10.986839
MA0114.10.537669
MA0115.11.38041
MA0116.10.602598
MA0117.11.34691
MA0119.10.716476
MA0122.11.36752
MA0124.11.57762
MA0125.11.5017
MA0130.10
MA0131.11.07881
MA0132.10
MA0133.10
MA0135.11.4152
MA0136.10.933582
MA0139.11.16863
MA0140.10.898603
MA0141.10.671467
MA0142.11.16183
MA0143.11.00467
MA0144.10.541532
MA0145.10.292366
MA0146.10.900029
MA0147.10.556853
MA0148.10.820161
MA0149.14.16251
MA0062.20.412742
MA0035.20.903829
MA0039.20.181475
MA0138.21.07027
MA0002.20.466067
MA0137.20.668025
MA0104.20.48458
MA0047.20.962424
MA0112.20.794478
MA0065.20.79573
MA0150.10.784464
MA0151.10
MA0152.10.962542
MA0153.11.43238
MA0154.10.35067
MA0155.10.312898
MA0156.10.656895
MA0157.11.12772
MA0158.10
MA0159.10.569393
MA0160.10.823568
MA0161.10
MA0162.10.499274
MA0163.12.84458
MA0164.10.933981
MA0080.20.64167
MA0018.20.944669
MA0099.21.06348
MA0079.24.46976
MA0102.22.01714
MA0258.10.520639
MA0259.10.543506
MA0442.10
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