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Coexpression cluster:C716

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Full id: C716_Melanocyte_Monocytederived_melanoma_Macrophage_Renal_CD14_Dendritic



Phase1 CAGE Peaks

Hg19::chr7:2671611..2671658,+p2@TTYH3
Hg19::chr7:2695761..2695776,+p10@TTYH3
Hg19::chr7:2696064..2696098,+p8@TTYH3
Hg19::chr7:2697935..2697953,+p@chr7:2697935..2697953
+
Hg19::chr7:2697957..2697994,+p@chr7:2697957..2697994
+
Hg19::chr7:2698019..2698038,+p@chr7:2698019..2698038
+
Hg19::chr7:2698048..2698063,+p@chr7:2698048..2698063
+
Hg19::chr7:2698578..2698617,+p9@TTYH3
Hg19::chr7:2701358..2701440,+p4@TTYH3
Hg19::chr7:2701441..2701465,+p14@TTYH3
Hg19::chr7:2701486..2701509,+p11@TTYH3
Hg19::chr7:2701540..2701595,+p6@TTYH3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
embryonic cell3.14e-21250
somatic cell6.13e-20588
animal cell1.04e-15679
eukaryotic cell1.04e-15679
mesodermal cell4.12e-15121
endothelial cell2.36e-1236
lining cell2.77e-1158
barrier cell2.77e-1158
non-terminally differentiated cell2.21e-10106
stuff accumulating cell3.73e-1087
ectodermal cell9.96e-1072
meso-epithelial cell9.97e-1045
neurectodermal cell1.25e-0959
native cell4.26e-08722
defensive cell4.54e-0848
phagocyte4.54e-0848
electrically responsive cell5.45e-0861
electrically active cell5.45e-0861
contractile cell7.61e-0859
monopoietic cell1.57e-0759
monocyte1.57e-0759
monoblast1.57e-0759
promonocyte1.57e-0759
smooth muscle cell2.37e-0743
smooth muscle myoblast2.37e-0743
fibroblast5.86e-0776
kidney cell6.28e-0717
kidney epithelial cell6.28e-0717
pigment cell7.20e-0714
macrophage dendritic cell progenitor9.81e-0761
Uber Anatomy
Ontology termp-valuen
anatomical system3.15e-20624
multi-cellular organism3.71e-20656
anatomical group8.58e-20625
developing anatomical structure1.42e-17581
embryo2.89e-17592
embryonic structure1.82e-15564
germ layer2.64e-15560
germ layer / neural crest2.64e-15560
embryonic tissue2.64e-15560
presumptive structure2.64e-15560
germ layer / neural crest derived structure2.64e-15560
epiblast (generic)2.64e-15560
mesoderm1.88e-13315
mesoderm-derived structure1.88e-13315
presumptive mesoderm1.88e-13315
vasculature3.98e-1378
vascular system3.98e-1378
lateral plate mesoderm6.69e-12203
epithelial tube2.28e-11117
vessel1.69e-1068
cell layer3.48e-10309
epithelial tube open at both ends5.82e-1059
blood vessel5.82e-1059
blood vasculature5.82e-1059
vascular cord5.82e-1059
epithelium1.05e-09306
musculoskeletal system1.18e-09167
splanchnic layer of lateral plate mesoderm1.37e-0983
artery1.44e-0942
arterial blood vessel1.44e-0942
arterial system1.44e-0942
anatomical cluster4.79e-09373
cardiovascular system4.86e-09109
circulatory system3.93e-08112
organ1.98e-07503
epithelial vesicle2.00e-0778
systemic artery3.72e-0733
systemic arterial system3.72e-0733
tube6.09e-07192


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.