Coexpression cluster:C659

Full id: C659_Adipocyte_mature_Mesenchymal_breast_heart_adipose_left

Phase1 CAGE Peaks

Hg19::chr11:819562..819579,+	p1@PNPLA2
Hg19::chr11:819601..819612,+	p3@PNPLA2
Hg19::chr11:821664..821701,+	p7@PNPLA2
Hg19::chr11:822561..822594,-	p@chr11:822561..822594 -
Hg19::chr11:825056..825073,-	p1@ENST00000528982
Hg19::chr12:109704726..109704729,+	p19@ACACB
Hg19::chr15:90208696..90208713,-	p@chr15:90208696..90208713 -
Hg19::chr17:41003273..41003300,+	p2@AOC3
Hg19::chr17:41005249..41005263,+	p@chr17:41005249..41005263 +
Hg19::chr17:80382262..80382282,+	p@chr17:80382262..80382282 +
Hg19::chr1:171238128..171238142,+	p@chr1:171238128..171238142 +
Hg19::chr1:219632507..219632553,-	p@chr1:219632507..219632553 -
Hg19::chr3:186574030..186574040,+	p@chr3:186574030..186574040 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0003989	acetyl-CoA carboxylase activity	0.00782859475616166
GO:0004075	biotin carboxylase activity	0.00782859475616166
GO:0048038	quinone binding	0.00782859475616166
GO:0016421	CoA carboxylase activity	0.00782859475616166
GO:0008131	amine oxidase activity	0.00782859475616166
GO:0016885	ligase activity, forming carbon-carbon bonds	0.00782859475616166
GO:0005811	lipid particle	0.00958518781345813
GO:0004806	triacylglycerol lipase activity	0.0134161027078255
GO:0009374	biotin binding	0.0134161027078255
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	0.0154262469877776
GO:0006629	lipid metabolic process	0.0156475119697776
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	0.0156475119697776
GO:0006633	fatty acid biosynthetic process	0.0370468956978877
GO:0016053	organic acid biosynthetic process	0.0370468956978877
GO:0046394	carboxylic acid biosynthetic process	0.0370468956978877
GO:0005507	copper ion binding	0.0489097875833071
GO:0016298	lipase activity	0.0494498284901388
GO:0016042	lipid catabolic process	0.0494498284901388
GO:0030145	manganese ion binding	0.0494498284901388
GO:0009986	cell surface	0.0494498284901388

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
fat cell	2.96e-32	15
subcutaneous fat cell	9.40e-12	3
adipocyte of omentum tissue	1.88e-11	3
adipocyte of breast	7.44e-08	2

Uber Anatomy

Ontology term	p-value	n
adult organism	7.90e-18	114
subcutaneous adipose tissue	9.40e-12	3
open tracheal system trachea	2.23e-07	2
male reproductive organ	2.71e-07	11
throat	3.30e-07	2
hypodermis	3.49e-07	5

Disease

Ontology term	p-value	n
heart disease	1.01e-07	2

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.