Coexpression cluster:C4736

Full id: C4736_Mesenchymal_Alveolar_Renal_Whole_blood_Pericytes_heart

Phase1 CAGE Peaks

Hg19::chr8:145158581..145158693,-	p1@SHARPIN
Hg19::chr8:145159376..145159407,+	p1@MAF1
Hg19::chr8:145159415..145159438,+	p2@MAF1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
mesodermal cell	2.44e-10	121
lining cell	1.46e-09	58
barrier cell	1.46e-09	58
meso-epithelial cell	1.53e-09	45
endothelial cell	1.69e-08	36
epithelial cell	1.21e-07	253

Uber Anatomy

Ontology term	p-value	n
circulatory system	4.43e-12	112
cardiovascular system	7.93e-11	109
epithelial tube	4.15e-09	117
splanchnic layer of lateral plate mesoderm	5.53e-09	83
vessel	4.06e-08	68
vasculature	5.87e-08	78
vascular system	5.87e-08	78
epithelial tube open at both ends	6.96e-08	59
blood vessel	6.96e-08	59
blood vasculature	6.96e-08	59
vascular cord	6.96e-08	59
trunk	8.84e-07	199

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191261462441879
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322627133658048
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0465139750939886
GABPB1#2553	3	7.06768383618217	0.00283221282541742	0.0154873802436656
HNF4A#3172	3	23.1322903629537	8.07584663437677e-05	0.00123453358701358
HNF4G#3174	3	28.7534225264468	4.20470658818262e-05	0.00076053922993281
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.012877421907991
IRF3#3661	2	31.3213014743264	0.00133951467332011	0.00888013031400784
MYC#4609	3	5.2222818716094	0.00702084375574015	0.0296214713179989
NANOG#79923	3	29.2447784810127	3.99627955670032e-05	0.000741459301158687
NFYA#4800	2	12.2837204665537	0.00851601140372443	0.0325003184606291
NFYB#4801	2	11.1731955023576	0.0102546713505453	0.0381636895976766
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173727763543405
PBX3#5090	2	14.6096751244961	0.00605612247321789	0.0268586935742666
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0278387779473322
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0247972082866484
SP2#6668	3	26.1535304938446	5.58768218891694e-05	0.000942917983726443
SREBF1#6720	2	31.3372329603255	0.0013381626513618	0.00887905776020174
STAT1#6772	2	13.8043916647995	0.00677093170844408	0.0287634466828632
THAP1#55145	2	20.9127630685675	0.00298344741373694	0.0158787272304577
ZBTB33#10009	2	21.1098166866541	0.00292859706060324	0.0156425995198866
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0140999702646217
ZNF143#7702	3	13.5008765522279	0.000406280496299717	0.00390534088845339

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.