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Coexpression cluster:C4047

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Full id: C4047_Neutrophils_CD14_Eosinophils_Peripheral_Basophils_Whole_CD14CD16



Phase1 CAGE Peaks

Hg19::chr20:46369826..46369840,+p@chr20:46369826..46369840
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Hg19::chr8:48266404..48266421,+p@chr8:48266404..48266421
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Hg19::chr8:48282265..48282276,+p@chr8:48282265..48282276
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte1.01e-7842
CD14-positive, CD16-negative classical monocyte1.01e-7842
myeloid leukocyte3.50e-7272
defensive cell2.16e-6748
phagocyte2.16e-6748
monopoietic cell2.03e-6059
monocyte2.03e-6059
monoblast2.03e-6059
promonocyte2.03e-6059
macrophage dendritic cell progenitor4.59e-5861
myeloid lineage restricted progenitor cell8.50e-5366
granulocyte monocyte progenitor cell7.75e-5267
leukocyte1.62e-47136
myeloid cell1.64e-45108
common myeloid progenitor1.64e-45108
nongranular leukocyte7.10e-39115
stuff accumulating cell8.62e-3887
hematopoietic stem cell5.61e-37168
angioblastic mesenchymal cell5.61e-37168
hematopoietic cell2.72e-34177
hematopoietic oligopotent progenitor cell7.08e-33161
hematopoietic multipotent progenitor cell7.08e-33161
hematopoietic lineage restricted progenitor cell2.34e-31120
intermediate monocyte4.82e-219
CD14-positive, CD16-positive monocyte4.82e-219
granulocyte9.94e-218
blood cell1.35e-1411
mesenchymal cell5.32e-12354
connective tissue cell1.82e-11361
motile cell1.33e-09386
neutrophil4.76e-093
basophil1.48e-083
non-classical monocyte2.74e-083
CD14-low, CD16-positive monocyte2.74e-083
single nucleate cell3.67e-083
mononuclear cell3.67e-083
natural killer cell1.99e-073
pro-NK cell1.99e-073
multi fate stem cell2.29e-07427
somatic stem cell4.61e-07433
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.26e-6098
blood island1.26e-6098
hemolymphoid system9.68e-56108
bone marrow1.11e-4676
bone element2.14e-4282
immune system1.40e-4193
skeletal element1.45e-3790
skeletal system1.29e-32100
lateral plate mesoderm1.18e-21203
blood2.83e-1515
haemolymphatic fluid2.83e-1515
organism substance2.83e-1515
musculoskeletal system7.05e-15167
mesoderm8.05e-11315
mesoderm-derived structure8.05e-11315
presumptive mesoderm8.05e-11315
connective tissue9.66e-11371


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105137.971147625824820.001974187055288560.011537891542657
NR3C1#290829.982015554115360.01278474365547170.0460533867703863



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.