MCL coexpression mm9:2533

Phase1 CAGE Peaks

	Short description
Mm9::chr10:127930011..127930023,-	p4@Myl6
Mm9::chr10:127930027..127930090,-	p2@Myl6
Mm9::chr19:34329815..34329832,-	p1@Acta2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030049	muscle filament sliding	0.00635477151876984
GO:0016461	unconventional myosin complex	0.00635477151876984
GO:0033275	actin-myosin filament sliding	0.00635477151876984
GO:0007010	cytoskeleton organization and biogenesis	0.00867692153529255
GO:0008307	structural constituent of muscle	0.0101662416797126
GO:0030048	actin filament-based movement	0.0158817059832277
GO:0005856	cytoskeleton	0.0183301361737783
GO:0006996	organelle organization and biogenesis	0.0262599155568277
GO:0016459	myosin complex	0.0338518410700433
GO:0043232	intracellular non-membrane-bound organelle	0.0338518410700433
GO:0043228	non-membrane-bound organelle	0.0338518410700433
GO:0003012	muscle system process	0.0388216747284698
GO:0006936	muscle contraction	0.0388216747284698
GO:0005200	structural constituent of cytoskeleton	0.0388216747284698
GO:0007519	skeletal muscle development	0.0388216747284698
GO:0030705	cytoskeleton-dependent intracellular transport	0.0388216747284698
GO:0014706	striated muscle development	0.0454561548028362

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	2.35e-08	23
circulatory system	2.35e-08	23
splanchnic layer of lateral plate mesoderm	1.42e-07	33

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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