MCL coexpression mm9:1803

Phase1 CAGE Peaks

	Short description
Mm9::chr4:43571258..43571293,-	p11@Tln1
Mm9::chr6:34548518..34548529,+	p9@Cald1
Mm9::chr6:34548530..34548587,+	p1@Cald1
Mm9::chr6:34548595..34548606,+	p8@Cald1
Mm9::chr6:34548615..34548626,+	p11@Cald1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0030478	actin cap	0.00525180931773736
GO:0003779	actin binding	0.00525180931773736
GO:0008092	cytoskeletal protein binding	0.00657354137709317
GO:0007016	cytoskeletal anchoring	0.00657354137709317
GO:0007044	cell-substrate junction assembly	0.00657354137709317
GO:0030866	cortical actin cytoskeleton organization and biogenesis	0.0087640014480281
GO:0030865	cortical cytoskeleton organization and biogenesis	0.00903713359305485
GO:0030864	cortical actin cytoskeleton	0.00903713359305485
GO:0006940	regulation of smooth muscle contraction	0.0101557694197892
GO:0030863	cortical cytoskeleton	0.0101557694197892
GO:0007028	cytoplasm organization and biogenesis	0.0101557694197892
GO:0005856	cytoskeleton	0.0110612890703835
GO:0006939	smooth muscle contraction	0.0120992024380542
GO:0005925	focal adhesion	0.0120992024380542
GO:0044448	cell cortex part	0.0120992024380542
GO:0005924	cell-substrate adherens junction	0.0120992024380542
GO:0006937	regulation of muscle contraction	0.0120992024380542
GO:0001726	ruffle	0.0120992024380542
GO:0030055	cell-matrix junction	0.0120992024380542
GO:0005938	cell cortex	0.0154300466598971
GO:0043232	intracellular non-membrane-bound organelle	0.0174074266334173
GO:0043228	non-membrane-bound organelle	0.0174074266334173
GO:0005912	adherens junction	0.0174074266334173
GO:0016323	basolateral plasma membrane	0.0191386856223827
GO:0031252	leading edge	0.0199446936446966
GO:0003012	muscle system process	0.020164369857969
GO:0006936	muscle contraction	0.020164369857969
GO:0005200	structural constituent of cytoskeleton	0.0206127218757387
GO:0030036	actin cytoskeleton organization and biogenesis	0.0347652712330674
GO:0030029	actin filament-based process	0.035995992192866
GO:0015629	actin cytoskeleton	0.0400852403630016

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
splanchnic layer of lateral plate mesoderm	3.05e-07	33
multi-cellular organism	3.57e-07	333
reproductive structure	3.75e-07	26
reproductive system	3.75e-07	26
cardiovascular system	9.39e-07	23
circulatory system	9.39e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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