MCL coexpression mm9:1477

Phase1 CAGE Peaks

	Short description
Mm9::chr7:149844662..149844672,-	p8@Igf2
Mm9::chrX:49625849..49625871,-	p@chrX:49625849..49625871 -
Mm9::chrX:49967074..49967087,-	p2@Gpc3
Mm9::chrX:49967090..49967101,-	p3@Gpc3
Mm9::chrX:49967113..49967156,-	p1@Gpc3
Mm9::chrX:49967416..49967437,-	p4@Gpc3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005159	insulin-like growth factor receptor binding	0.00723129172825533
GO:0018445	prothoracicotrophic hormone activity	0.00723129172825533
GO:0030513	positive regulation of BMP signaling pathway	0.00723129172825533
GO:0008283	cell proliferation	0.00980652068650246
GO:0009887	organ morphogenesis	0.00980652068650246
GO:0030510	regulation of BMP signaling pathway	0.017166789799002
GO:0001658	ureteric bud branching	0.017166789799002
GO:0005184	neuropeptide hormone activity	0.017166789799002
GO:0045926	negative regulation of growth	0.0200748149452051
GO:0030509	BMP signaling pathway	0.0202856665377052
GO:0001657	ureteric bud development	0.0202856665377052
GO:0009653	anatomical structure morphogenesis	0.0202856665377052
GO:0001656	metanephros development	0.0247492752265413
GO:0048513	organ development	0.0247492752265413
GO:0048754	branching morphogenesis of a tube	0.0271467911307937
GO:0001763	morphogenesis of a branching structure	0.0271467911307937
GO:0009967	positive regulation of signal transduction	0.0271467911307937
GO:0001822	kidney development	0.0271467911307937
GO:0048731	system development	0.0271467911307937
GO:0001655	urogenital system development	0.0271467911307937
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	0.0271467911307937
GO:0048856	anatomical structure development	0.0319733690770696
GO:0005615	extracellular space	0.0319733690770696
GO:0008285	negative regulation of cell proliferation	0.0319733690770696
GO:0048503	GPI anchor binding	0.0319733690770696
GO:0005179	hormone activity	0.0319733690770696
GO:0044421	extracellular region part	0.0319733690770696
GO:0007275	multicellular organismal development	0.0321147276600331
GO:0035239	tube morphogenesis	0.0346178339930072
GO:0040008	regulation of growth	0.0346178339930072
GO:0008083	growth factor activity	0.0346178339930072
GO:0035091	phosphoinositide binding	0.0368969072946606
GO:0005543	phospholipid binding	0.0425178054670808
GO:0035295	tube development	0.0425178054670808
GO:0032502	developmental process	0.0444869144100882

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
multi-cellular organism	8.81e-11	333
embryo	3.24e-07	320
trunk region element	4.11e-07	79

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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