MCL coexpression mm9:3442

Phase1 CAGE Peaks

	Short description
Mm9::chr4:102243229..102243249,+	p@chr4:102243229..102243249 +
Mm9::chr4:102243268..102243284,+	p@chr4:102243268..102243284 +
Mm9::chr6:134742388..134742404,-	p3@Dusp16

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042578	phosphoric ester hydrolase activity	0.00971803541665609
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	0.0108238311442
GO:0000188	inactivation of MAPK activity	0.0108238311442
GO:0016788	hydrolase activity, acting on ester bonds	0.0108238311442
GO:0043407	negative regulation of MAP kinase activity	0.0148951284823575
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	0.0162679755075525
GO:0004112	cyclic-nucleotide phosphodiesterase activity	0.0162679755075525
GO:0006469	negative regulation of protein kinase activity	0.0166379153774271
GO:0033673	negative regulation of kinase activity	0.0166379153774271
GO:0051348	negative regulation of transferase activity	0.0166379153774271
GO:0043086	negative regulation of catalytic activity	0.0187030868604814
GO:0043405	regulation of MAP kinase activity	0.0218757851855045
GO:0008081	phosphoric diester hydrolase activity	0.0218757851855045
GO:0016787	hydrolase activity	0.0327506438198464
GO:0000165	MAPKKK cascade	0.0327506438198464
GO:0045859	regulation of protein kinase activity	0.0327506438198464
GO:0043549	regulation of kinase activity	0.0327506438198464
GO:0051338	regulation of transferase activity	0.0327506438198464
GO:0007243	protein kinase cascade	0.0490044002385492
GO:0016791	phosphoric monoester hydrolase activity	0.0490044002385492

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
epithelial fold	3.44e-09	20
epithelial bud	4.85e-09	17
lung	2.81e-08	14
respiratory tube	2.81e-08	14
respiration organ	2.81e-08	14
pair of lungs	2.81e-08	14
lung primordium	2.81e-08	14
lung bud	2.81e-08	14
thoracic cavity element	1.19e-07	17
thoracic segment organ	1.19e-07	17
thoracic cavity	1.19e-07	17
thoracic segment of trunk	1.19e-07	17
respiratory primordium	1.19e-07	17
endoderm of foregut	1.19e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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