MCL coexpression mm9:2303

Phase1 CAGE Peaks

	Short description
Mm9::chr1:196802536..196802585,+	p1@A330023F24Rik
Mm9::chr1:196802594..196802625,+	p1@ENSMUST00000172133
Mm9::chr8:67373820..67373879,-	p1@Klhl2 p1@LOC100502725
Mm9::chr9:123438689..123438729,-	p@chr9:123438689..123438729 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0001725	stress fiber	0.0120528132361804
GO:0032432	actin filament bundle	0.0120528132361804
GO:0042803	protein homodimerization activity	0.0397742836793952
GO:0042802	identical protein binding	0.0397742836793952
GO:0015629	actin cytoskeleton	0.0397742836793952
GO:0046983	protein dimerization activity	0.0397742836793952
GO:0003779	actin binding	0.0416682971879378

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	2.65e-11	54
neural tube	2.48e-10	52
neural rod	2.48e-10	52
future spinal cord	2.48e-10	52
neural keel	2.48e-10	52
nervous system	1.66e-09	75
adult organism	2.34e-09	51
neurectoderm	2.39e-09	64
neural plate	2.39e-09	64
presumptive neural plate	2.39e-09	64
central nervous system	3.06e-09	73
brain	5.58e-09	47
future brain	5.58e-09	47
ectoderm-derived structure	9.31e-09	95
ectoderm	9.31e-09	95
presumptive ectoderm	9.31e-09	95
gray matter	1.74e-08	34
regional part of brain	1.88e-08	46
ecto-epithelium	1.50e-07	73
occipital lobe	1.68e-07	10
visual cortex	1.68e-07	10
neocortex	1.68e-07	10
brain grey matter	4.78e-07	29
regional part of telencephalon	4.78e-07	29
telencephalon	4.78e-07	29
pre-chordal neural plate	6.76e-07	49
anterior neural tube	6.92e-07	40
anatomical conduit	7.07e-07	122
structure with developmental contribution from neural crest	7.24e-07	92

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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