MCL coexpression mm9:1570

Phase1 CAGE Peaks

	Short description
Mm9::chr11:53914471..53914527,+	p1@P4ha2
Mm9::chr1:184447871..184447905,-	p4@Capn2
Mm9::chr7:3290554..3290587,+	p1@Myadm
Mm9::chr7:3290589..3290615,+	p2@Myadm
Mm9::chr7:3298094..3298120,+	p@chr7:3298094..3298120 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019511	peptidyl-proline hydroxylation	0.0093672964811066
GO:0031545	peptidyl-proline 4-dioxygenase activity	0.0093672964811066
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	0.0093672964811066
GO:0019471	4-hydroxyproline metabolic process	0.0093672964811066
GO:0004656	procollagen-proline 4-dioxygenase activity	0.0093672964811066
GO:0018208	peptidyl-proline modification	0.00993283416100164
GO:0019798	procollagen-proline dioxygenase activity	0.00993283416100164
GO:0031543	peptidyl-proline dioxygenase activity	0.00993283416100164
GO:0014902	myotube differentiation	0.00993283416100164
GO:0000768	syncytium formation by plasma membrane fusion	0.00993283416100164
GO:0007520	myoblast fusion	0.00993283416100164
GO:0006949	syncytium formation	0.0104052560816558
GO:0045026	plasma membrane fusion	0.0156027531384348
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	0.0156027531384348
GO:0031418	L-ascorbic acid binding	0.0190616721487593
GO:0048628	myoblast maturation	0.0190616721487593
GO:0006944	membrane fusion	0.0190616721487593
GO:0048627	myoblast development	0.0190616721487593
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	0.0205175648105699
GO:0001824	blastocyst development	0.0241617432618843
GO:0045445	myoblast differentiation	0.0267153414079534
GO:0051213	dioxygenase activity	0.0366732105111305
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	0.0366732105111305
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	0.0366732105111305
GO:0042692	muscle cell differentiation	0.0366732105111305
GO:0048741	skeletal muscle fiber development	0.0366732105111305
GO:0048747	muscle fiber development	0.0366732105111305
GO:0046483	heterocycle metabolic process	0.0366732105111305
GO:0048469	cell maturation	0.0396831511208595
GO:0004197	cysteine-type endopeptidase activity	0.0430045899037992
GO:0006575	amino acid derivative metabolic process	0.0434026917891086
GO:0021700	developmental maturation	0.0434026917891086
GO:0018193	peptidyl-amino acid modification	0.0434026917891086
GO:0007519	skeletal muscle development	0.0434026917891086
GO:0019842	vitamin binding	0.0465752133802208

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
cardiovascular system	2.38e-11	23
circulatory system	2.38e-11	23
splanchnic layer of lateral plate mesoderm	2.83e-10	33
primary circulatory organ	1.26e-09	18
heart	1.26e-09	18
primitive heart tube	1.26e-09	18
primary heart field	1.26e-09	18
anterior lateral plate mesoderm	1.26e-09	18
heart tube	1.26e-09	18
heart primordium	1.26e-09	18
cardiac mesoderm	1.26e-09	18
cardiogenic plate	1.26e-09	18
heart rudiment	1.26e-09	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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