MCL coexpression mm9:511

Phase1 CAGE Peaks

	Short description
Mm9::chr10:29032970..29033027,+	p2@Echdc1
Mm9::chr12:85791894..85791968,-	p1@Aldh6a1
Mm9::chr13:100785517..100785602,-	p1@Mccc2
Mm9::chr14:122933527..122933589,+	p1@Pcca
Mm9::chr14:17075823..17075858,-	p1@Oxsm
Mm9::chr17:41071625..41071700,+	p1@Mut
Mm9::chr17:59152687..59152766,-	p1@Nudt12
Mm9::chr1:9538130..9538182,+	p1@Adhfe1
Mm9::chr2:103325295..103325315,-	p2@Cat
Mm9::chr3:116216012..116216062,+	p1@Dbt
Mm9::chr6:13019879..13019895,+	p2@Tmem106b
Mm9::chr6:52590297..52590380,-	p1@Hibadh
Mm9::chr7:138554147..138554240,+	p1@Acadsb
Mm9::chr9:100935276..100935286,-	p1@Pccb

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0005739	mitochondrion	6.27523475493706e-07
GO:0016421	CoA carboxylase activity	6.99466227946502e-07
GO:0016885	ligase activity, forming carbon-carbon bonds	8.15675020897826e-07
GO:0004658	propionyl-CoA carboxylase activity	2.66318474284288e-05
GO:0044444	cytoplasmic part	0.000348096818503853
GO:0019752	carboxylic acid metabolic process	0.000401318676234845
GO:0006082	organic acid metabolic process	0.000401318676234845
GO:0032787	monocarboxylic acid metabolic process	0.000401318676234845
GO:0050662	coenzyme binding	0.00187420164834863
GO:0006631	fatty acid metabolic process	0.00437035419185468
GO:0048037	cofactor binding	0.00458679476633284
GO:0006767	water-soluble vitamin metabolic process	0.00647224500148516
GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	0.00712211691228839
GO:0050093	methanol dehydrogenase activity	0.00712211691228839
GO:0008442	3-hydroxyisobutyrate dehydrogenase activity	0.00712211691228839
GO:0006768	biotin metabolic process	0.00712211691228839
GO:0004494	methylmalonyl-CoA mutase activity	0.00712211691228839
GO:0016937	short-branched-chain-acyl-CoA dehydrogenase activity	0.00712211691228839
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	0.00712211691228839
GO:0006573	valine metabolic process	0.00712211691228839
GO:0000210	NAD+ diphosphatase activity	0.00712211691228839
GO:0006766	vitamin metabolic process	0.00891888207802721
GO:0006633	fatty acid biosynthetic process	0.00996741276421327
GO:0005737	cytoplasm	0.00996741276421327
GO:0046394	carboxylic acid biosynthetic process	0.00996741276421327
GO:0016053	organic acid biosynthetic process	0.00996741276421327
GO:0009343	biotin carboxylase complex	0.00996741276421327
GO:0004485	methylcrotonoyl-CoA carboxylase activity	0.00996741276421327
GO:0009317	acetyl-CoA carboxylase complex	0.00996741276421327
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	0.00996741276421327
GO:0016874	ligase activity	0.0108751984293086
GO:0016491	oxidoreductase activity	0.0128106815241885
GO:0004075	biotin carboxylase activity	0.0128106815241885
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	0.0128106815241885
GO:0003989	acetyl-CoA carboxylase activity	0.0128106815241885
GO:0019842	vitamin binding	0.0154437815892189
GO:0009374	biotin binding	0.0160294455529876
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0160294455529876
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.0173664581883205
GO:0031406	carboxylic acid binding	0.0173664581883205
GO:0031419	cobalamin binding	0.0173664581883205
GO:0004312	fatty-acid synthase activity	0.0173664581883205
GO:0031405	lipoic acid binding	0.0173664581883205
GO:0009081	branched chain family amino acid metabolic process	0.0232159235755607
GO:0004551	nucleotide diphosphatase activity	0.0232159235755607
GO:0006098	pentose-phosphate shunt	0.0249314317801191
GO:0006740	NADPH regeneration	0.0249314317801191
GO:0044255	cellular lipid metabolic process	0.0249314317801191
GO:0008415	acyltransferase activity	0.0286860817617896
GO:0016747	transferase activity, transferring groups other than amino-acyl groups	0.0287585165101509
GO:0043231	intracellular membrane-bound organelle	0.028983523454345
GO:0043227	membrane-bound organelle	0.028983523454345
GO:0016746	transferase activity, transferring acyl groups	0.0293142905754877
GO:0050897	cobalt ion binding	0.0303585470970815
GO:0051186	cofactor metabolic process	0.0310630974510198
GO:0006629	lipid metabolic process	0.0314364698181849
GO:0006739	NADP metabolic process	0.0365655058362674
GO:0003995	acyl-CoA dehydrogenase activity	0.041039433488073
GO:0008610	lipid biosynthetic process	0.045193925620091

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
epithelial tube	1.96e-11	47
trunk region element	5.93e-11	79
exocrine gland	9.27e-10	25
exocrine system	9.27e-10	25
mesenchyme	3.07e-09	61
entire embryonic mesenchyme	3.07e-09	61
trunk	4.49e-09	90
abdomen element	9.84e-09	49
abdominal segment element	9.84e-09	49
abdominal segment of trunk	9.84e-09	49
abdomen	9.84e-09	49
digestive tract diverticulum	1.99e-08	23
sac	1.99e-08	23
liver	2.21e-08	22
epithelial sac	2.21e-08	22
digestive gland	2.21e-08	22
epithelium of foregut-midgut junction	2.21e-08	22
anatomical boundary	2.21e-08	22
hepatobiliary system	2.21e-08	22
foregut-midgut junction	2.21e-08	22
hepatic diverticulum	2.21e-08	22
liver primordium	2.21e-08	22
septum transversum	2.21e-08	22
liver bud	2.21e-08	22
multi-cellular organism	2.88e-08	333
anatomical conduit	8.92e-08	122
subdivision of trunk	1.06e-07	66
trunk mesenchyme	1.58e-07	45
tissue	4.88e-07	349

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}