MCL coexpression mm9:2213

Phase1 CAGE Peaks

	Short description
Mm9::chr17:43639666..43639688,-	p1@Mep1a
Mm9::chr3:96628027..96628046,+	p@chr3:96628027..96628046 +
Mm9::chr4:106406488..106406503,+	p1@Fam151a
Mm9::chrX:160578379..160578427,+	p2@Ace2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008237	metallopeptidase activity	0.00330625718654662
GO:0004238	meprin A activity	0.00339660886188538
GO:0008533	astacin activity	0.00679247332273811
GO:0008233	peptidase activity	0.0102100649887315
GO:0004180	carboxypeptidase activity	0.0261650848256211
GO:0043168	anion binding	0.0261650848256211
GO:0031404	chloride ion binding	0.0261650848256211
GO:0008270	zinc ion binding	0.0349106489382693
GO:0008238	exopeptidase activity	0.0349106489382693
GO:0004222	metalloendopeptidase activity	0.0349106489382693
GO:0016787	hydrolase activity	0.0349106489382693
GO:0046914	transition metal ion binding	0.0401503552812013

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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