MCL coexpression mm9:1588

Phase1 CAGE Peaks

	Short description
Mm9::chr11:83476081..83476096,+	p1@Ccl4
Mm9::chr17:35138887..35138905,-	p1@ENSMUST00000173893
Mm9::chr5:122287249..122287264,+	p@chr5:122287249..122287264 +
Mm9::chr5:124928280..124928291,-	p3@Rilpl2
Mm9::chr5:124928310..124928337,-	p2@Rilpl2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008009	chemokine activity	0.0220968242663307
GO:0042379	chemokine receptor binding	0.0220968242663307
GO:0001664	G-protein-coupled receptor binding	0.0220968242663307
GO:0042330	taxis	0.0248287952665315
GO:0006935	chemotaxis	0.0248287952665315
GO:0007626	locomotory behavior	0.0322412754067824
GO:0006954	inflammatory response	0.0322412754067824
GO:0005125	cytokine activity	0.0322412754067824
GO:0009611	response to wounding	0.0376047772968827
GO:0007610	behavior	0.0376047772968827
GO:0042221	response to chemical stimulus	0.0439927683120583
GO:0009605	response to external stimulus	0.0439927683120583
GO:0006955	immune response	0.0442245531819849

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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