MCL coexpression mm9:2189

Phase1 CAGE Peaks

	Short description
Mm9::chr16:92498853..92498863,+	p@chr16:92498853..92498863 +
Mm9::chr16:92498918..92498987,+	p@chr16:92498918..92498987 +
Mm9::chr16:92499010..92499069,+	p@chr16:92499010..92499069 +
Mm9::chr3:30039329..30039355,-	p5@Mecom

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005247	voltage-gated chloride channel activity	0.0131485235303786
GO:0022844	voltage-gated anion channel activity	0.0131485235303786
GO:0043168	anion binding	0.0150268840347184
GO:0031404	chloride ion binding	0.0150268840347184
GO:0005254	chloride channel activity	0.0150268840347184
GO:0006821	chloride transport	0.0150268840347184
GO:0005253	anion channel activity	0.0150268840347184
GO:0008509	anion transmembrane transporter activity	0.0243978158841469
GO:0015698	inorganic anion transport	0.0243978158841469
GO:0006820	anion transport	0.0243978158841469
GO:0005244	voltage-gated ion channel activity	0.0243978158841469
GO:0022832	voltage-gated channel activity	0.0243978158841469
GO:0022836	gated channel activity	0.0349278727627492
GO:0005216	ion channel activity	0.0384658766810291
GO:0022838	substrate specific channel activity	0.0384658766810291
GO:0015267	channel activity	0.0384658766810291
GO:0022803	passive transmembrane transporter activity	0.0384658766810291

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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