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MCL coexpression mm9:1611

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Phase1 CAGE Peaks

 Short description
Mm9::chr12:103521071..103521081,+p7@Rin3
Mm9::chr19:29436320..29436384,-p1@5033414D02Rik
Mm9::chr1:87857604..87857648,-p1@Gpr55
Mm9::chr4:133899797..133899824,+p5@Slc30a2
Mm9::chr9:46036430..46036457,+p4@Apoa1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0043534blood vessel endothelial cell migration0.0211130385121345
GO:0008035high-density lipoprotein binding0.0211130385121345
GO:0033344cholesterol efflux0.0211130385121345
GO:0030300regulation of cholesterol absorption0.0211130385121345
GO:0030299cholesterol absorption0.0211130385121345
GO:0044241lipid digestion0.0211130385121345
GO:0051346negative regulation of hydrolase activity0.0211130385121345
GO:0017127cholesterol transporter activity0.0211130385121345
GO:0043542endothelial cell migration0.0211130385121345
GO:0015248sterol transporter activity0.0211130385121345
GO:0001935endothelial cell proliferation0.0211130385121345
GO:0050892intestinal absorption0.0211130385121345
GO:0008211glucocorticoid metabolic process0.0211130385121345
GO:0030325adrenal gland development0.0211130385121345
GO:0019915sequestering of lipid0.021892603712342
GO:0008034lipoprotein binding0.025103850034829
GO:0022600digestive system process0.025103850034829
GO:0030301cholesterol transport0.0255301778494967
GO:0015918sterol transport0.0259112507101296
GO:0006695cholesterol biosynthetic process0.03607532601436
GO:0016126sterol biosynthetic process0.0452546430490102



Relative expression of the co-expression cluster over median <br>Analyst:



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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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