MCL coexpression mm9:763

Phase1 CAGE Peaks

	Short description
Mm9::chr10:42303385..42303401,-	p1@Nr2e1
Mm9::chr10:42303410..42303422,-	p3@Nr2e1
Mm9::chr10:42303434..42303445,-	p4@Nr2e1
Mm9::chr10:42303452..42303470,-	p2@Nr2e1
Mm9::chr10:42303593..42303617,+	p3@Ostm1
Mm9::chr13:100214377..100214396,-	p5@Mtap1b
Mm9::chr13:100214398..100214443,-	p4@Mtap1b
Mm9::chr15:30387382..30387465,+	p@chr15:30387382..30387465 +
Mm9::chr4:154335024..154335039,+	p1@Hes5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045665	negative regulation of neuron differentiation	0.000794495253785691
GO:0045664	regulation of neuron differentiation	0.000838742615128936
GO:0030182	neuron differentiation	0.000838742615128936
GO:0048699	generation of neurons	0.00091378028845023
GO:0022008	neurogenesis	0.00091378028845023
GO:0048731	system development	0.00163346912530473
GO:0048869	cellular developmental process	0.00163346912530473
GO:0030154	cell differentiation	0.00163346912530473
GO:0048856	anatomical structure development	0.00235172011241831
GO:0045596	negative regulation of cell differentiation	0.00235172011241831
GO:0007399	nervous system development	0.00251666452717617
GO:0045165	cell fate commitment	0.00251666452717617
GO:0007275	multicellular organismal development	0.00251666452717617
GO:0051093	negative regulation of developmental process	0.00251666452717617
GO:0021960	anterior commissure morphogenesis	0.00268814258843295
GO:0045595	regulation of cell differentiation	0.00476361711834936
GO:0032502	developmental process	0.00537390981097135
GO:0007423	sensory organ development	0.00537390981097135
GO:0021988	olfactory lobe development	0.00537390981097135
GO:0042668	auditory receptor cell fate determination	0.00537390981097135
GO:0021772	olfactory bulb development	0.00537390981097135
GO:0008347	glial cell migration	0.00537390981097135
GO:0031175	neurite development	0.00537390981097135
GO:0048666	neuron development	0.00625326153862338
GO:0048468	cell development	0.00625326153862338
GO:0060120	inner ear receptor cell fate commitment	0.00719801520321865
GO:0009912	auditory receptor cell fate commitment	0.00719801520321865
GO:0021952	central nervous system projection neuron axonogenesis	0.00719801520321865
GO:0050793	regulation of developmental process	0.00721312630204343
GO:0032990	cell part morphogenesis	0.00721312630204343
GO:0048858	cell projection morphogenesis	0.00721312630204343
GO:0030030	cell projection organization and biogenesis	0.00721312630204343
GO:0048513	organ development	0.00801501860859627
GO:0005519	cytoskeletal regulatory protein binding	0.00829752406539178
GO:0021987	cerebral cortex development	0.00895532164740805
GO:0035176	social behavior	0.00895532164740805
GO:0001578	microtubule bundle formation	0.00915266077810837
GO:0060041	retina development in camera-type eye	0.00915266077810837
GO:0021955	central nervous system neuron axonogenesis	0.00915266077810837
GO:0005829	cytosol	0.00915266077810837
GO:0032501	multicellular organismal process	0.00988022014933451
GO:0021543	pallium development	0.0131141185809079
GO:0016439	tRNA-pseudouridine synthase activity	0.0131141185809079
GO:0000902	cell morphogenesis	0.0150329301666908
GO:0032989	cellular structure morphogenesis	0.0150329301666908
GO:0009982	pseudouridine synthase activity	0.0157561972414516
GO:0030316	osteoclast differentiation	0.0171315822530225
GO:0021954	central nervous system neuron development	0.0176119602344722
GO:0051705	behavioral interaction between organisms	0.0180725959911146
GO:0042491	auditory receptor cell differentiation	0.0181516412460269
GO:0021537	telencephalon development	0.0181516412460269
GO:0021953	central nervous system neuron differentiation	0.0182245960741205
GO:0001709	cell fate determination	0.0182245960741205
GO:0060113	inner ear receptor cell differentiation	0.0201180295317525
GO:0016866	intramolecular transferase activity	0.0212118888217189
GO:0042490	mechanoreceptor differentiation	0.0236988425884903
GO:0016358	dendrite development	0.0275027898001106
GO:0002573	myeloid leukocyte differentiation	0.0277193658618234
GO:0042063	gliogenesis	0.0279284885099959
GO:0005496	steroid binding	0.0309506211559055
GO:0003707	steroid hormone receptor activity	0.0309506211559055
GO:0004879	ligand-dependent nuclear receptor activity	0.031096763193158
GO:0048523	negative regulation of cellular process	0.0330922663318068
GO:0048519	negative regulation of biological process	0.037446062826476
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.039496706719972
GO:0048839	inner ear development	0.0425239977973949
GO:0048469	cell maturation	0.0441397823276559
GO:0043010	camera-type eye development	0.0441397823276559
GO:0043583	ear development	0.0441397823276559

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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