Coexpression cluster:C2187

Full id: C2187_granulocyte_CD14_migratory_Eosinophils_Neutrophils_CD34_acute

Phase1 CAGE Peaks

Hg19::chr12:11802753..11802834,+	p2@ETV6
Hg19::chr12:11802932..11802949,+	p3@ETV6
Hg19::chr12:11802957..11802964,+	p8@ETV6
Hg19::chr12:11803027..11803034,+	p12@ETV6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
myeloid cell	6.51e-37	108
common myeloid progenitor	6.51e-37	108
myeloid leukocyte	1.45e-35	72
hematopoietic cell	1.77e-34	177
granulocyte monocyte progenitor cell	7.18e-33	67
hematopoietic stem cell	1.04e-32	168
angioblastic mesenchymal cell	1.04e-32	168
hematopoietic oligopotent progenitor cell	1.92e-30	161
hematopoietic multipotent progenitor cell	1.92e-30	161
leukocyte	3.46e-30	136
macrophage dendritic cell progenitor	1.22e-29	61
myeloid lineage restricted progenitor cell	2.06e-29	66
monopoietic cell	1.26e-28	59
monocyte	1.26e-28	59
monoblast	1.26e-28	59
promonocyte	1.26e-28	59
defensive cell	3.01e-26	48
phagocyte	3.01e-26	48
classical monocyte	3.35e-24	42
CD14-positive, CD16-negative classical monocyte	3.35e-24	42
hematopoietic lineage restricted progenitor cell	3.26e-22	120
nongranular leukocyte	3.87e-21	115
stuff accumulating cell	3.42e-10	87
dendritic cell	2.65e-07	10

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	5.67e-34	108
hematopoietic system	6.66e-34	98
blood island	6.66e-34	98
immune system	3.29e-30	93
bone marrow	1.98e-29	76
bone element	1.49e-25	82
skeletal element	1.42e-22	90
skeletal system	1.72e-19	100
lateral plate mesoderm	4.13e-17	203

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0185633156405763
IRF4#3662	4	21.9145126867441	4.33289161192893e-06	0.000136015289166891
NFKB1#4790	4	5.48806342419384	0.00110219956630198	0.00766701881610579
SIN3A#25942	4	5.40888472681514	0.00116817238488516	0.00794702681767983
SIX5#147912	3	12.8150365165942	0.000766447113693038	0.00601359553053769
SP1#6667	4	5.6983813781409	0.000948260606533398	0.0068309690637151
SPI1#6688	4	8.20432350852273	0.00022066188152768	0.00249088913152501
STAT1#6772	4	20.7065874971992	5.43610708103893e-06	0.000164993196000182
STAT2#6773	4	65.2637711864407	5.50053512607993e-08	3.45650052967907e-06
STAT3#6774	4	10.5194649971542	8.16377768286615e-05	0.001229262943225
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0321380549029636
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0243581136376883
TCF7L2#6934	3	8.07763242235301	0.00297838168583462	0.0158582311948448
ZBTB7A#51341	4	7.3519093078759	0.00034222354001599	0.00345963452673797

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.