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Coexpression cluster:C448

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Full id: C448_Eosinophils_CD19_Neutrophils_immature_CD14_CD34_CD4



Phase1 CAGE Peaks

Hg19::chr11:64619474..64619518,+p@chr11:64619474..64619518
+
Hg19::chr13:25861327..25861345,-p@chr13:25861327..25861345
-
Hg19::chr13:25861383..25861392,-p8@MTMR6
Hg19::chr13:25861424..25861442,-p3@MTMR6
Hg19::chr13:25861448..25861459,-p6@MTMR6
Hg19::chr13:25861474..25861481,-p5@MTMR6
Hg19::chr13:25861499..25861517,-p2@MTMR6
Hg19::chr15:55611198..55611219,+p5@PIGB
Hg19::chr17:3817800..3817817,+p@chr17:3817800..3817817
+
Hg19::chr19:18112074..18112107,+p4@ARRDC2
Hg19::chr19:18112109..18112115,+p10@ARRDC2
Hg19::chr1:172502624..172502648,-p1@BC034700
Hg19::chr21:43934531..43934564,-p@chr21:43934531..43934564
-
Hg19::chr22:50354104..50354157,+p2@PIM3
Hg19::chr22:50628844..50628860,-p@chr22:50628844..50628860
-
Hg19::chr2:158326065..158326081,-p@chr2:158326065..158326081
-
Hg19::chr3:42054612..42054635,+p@chr3:42054612..42054635
+
Hg19::chr6:30294289..30294313,+p2@TRIM39
Hg19::chr6:33378569..33378612,+p4@PHF1
Hg19::chr8:141608042..141608073,+p1@BC078139
Hg19::chr9:88356530..88356542,+p@chr9:88356530..88356542
+
Hg19::chrX:38186665..38186679,-p8@RPGR


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte1.90e-54140
hematopoietic stem cell7.30e-49172
angioblastic mesenchymal cell7.30e-49172
hematopoietic cell1.05e-45182
hematopoietic oligopotent progenitor cell9.66e-45165
hematopoietic multipotent progenitor cell9.66e-45165
nongranular leukocyte2.48e-42119
hematopoietic lineage restricted progenitor cell9.44e-42124
myeloid leukocyte4.12e-2576
CD14-positive, CD16-negative classical monocyte3.45e-2342
myeloid cell2.20e-22112
common myeloid progenitor2.20e-22112
granulocyte monocyte progenitor cell7.94e-2271
lymphocyte2.16e-2153
common lymphoid progenitor2.16e-2153
lymphoid lineage restricted progenitor cell5.80e-2152
classical monocyte2.03e-2045
macrophage dendritic cell progenitor1.23e-1965
myeloid lineage restricted progenitor cell5.65e-1970
monopoietic cell1.72e-1863
monocyte1.72e-1863
monoblast1.72e-1863
promonocyte1.72e-1863
lymphocyte of B lineage2.21e-1224
pro-B cell2.21e-1224
B cell4.76e-0914
T cell2.85e-0825
pro-T cell2.85e-0825
mature alpha-beta T cell3.54e-0718
alpha-beta T cell3.54e-0718
immature T cell3.54e-0718
mature T cell3.54e-0718
immature alpha-beta T cell3.54e-0718
granulocyte9.55e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.78e-26102
blood island4.78e-26102
hemolymphoid system4.68e-25112
bone marrow7.31e-1880
bone element1.52e-1686
skeletal element3.02e-12101
skeletal system3.02e-12101
immune system2.27e-11115
blood7.66e-0815
haemolymphatic fluid7.66e-0815
organism substance7.66e-0815
lateral plate mesoderm6.88e-07216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#905133.744119113659744.52148768906304e-060.00014138312956828
CHD2#110694.231645704865990.000113058509480530.00154916264387787
CTCF#10664112.680128186537510.0008685684342533290.00648038424810569
CTCFL#140690108.975670163170164.06420961939136e-082.68137705899946e-06
E2F1#1869132.899820899701427.94249971490149e-050.00121646389166241
E2F6#1876132.964682932366646.23302721693576e-050.00102081092913526
EBF1#1879156.072591031751594.43514475306916e-104.33304099967999e-08
EGR1#1958153.401031201006911.35216734815753e-065.32098740294742e-05
ELF1#1997142.709698701059346.92225188485253e-050.00109921402554677
ELK4#200575.165898709512550.0002509219292283070.00270388313729623
ETS1#211373.095514838882560.005114965700967340.0237835315811107
HEY1#23462132.387338343653370.0006313022577310590.00518419378008917
HMGN3#932493.345769523188880.0006755108910917370.00545037715966702
MAX#4149133.812873709867853.66862353649845e-060.000120373035981263
MYC#4609143.323270281933265.92563771949817e-060.000177784452107633
NFKB1#4790153.741861425586713.73038743635991e-071.83340203983996e-05
NRF1#4899105.550127021686773.47417705175917e-060.000115701395761695
PAX5#5079133.94110690478692.50523996824564e-068.82146854496312e-05
POLR2A#5430222.147453176558074.97800844931664e-083.19544083858746e-06
RAD21#588573.294783512190650.003605583472029610.0182523160406815
REST#5978104.38637668914912.82986167844788e-050.000596945917663944
SIN3A#25942143.442017553427813.84586327170977e-060.000125557397384838
SMC3#912674.787024087024090.0004000926554224890.00390626127322327
SPI1#6688124.475085550103312.11279115254993e-067.6991554494474e-05
TAF1#6872182.735219688337067.10005359864782e-073.17840762018508e-05
TBP#6908162.695833226979191.01813841677941e-050.000266767080055256
TCF12#6938115.317232451093211.33198496006276e-065.24947838656585e-05
TCF7L2#693483.916427841140850.0005334871023112230.00461155930129795
YY1#7528112.455585374926930.001852671170780720.010933555088725
ZEB1#693596.908904007177032.1839493953915e-067.83543424614541e-05
ZNF143#770284.90940965535560.0001121509054876940.00154994421307785
ZNF263#10127103.737200744095760.0001131597360736970.00155034627781724



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.