Coexpression cluster:C406

Full id: C406_Mallassezderived_Mesothelial_mesenchymal_chorionic_Gingival_Placental_Prostate

Phase1 CAGE Peaks

Hg19::chr10:106205466..106205487,+	p@chr10:106205466..106205487 +
Hg19::chr10:106205489..106205498,+	p@chr10:106205489..106205498 +
Hg19::chr10:106205503..106205518,+	p@chr10:106205503..106205518 +
Hg19::chr10:106205565..106205599,+	p@chr10:106205565..106205599 +
Hg19::chr10:118187325..118187332,+	p5@PNLIPRP3
Hg19::chr12:122380361..122380372,+	p@chr12:122380361..122380372 +
Hg19::chr12:56915776..56915787,+	p3@RBMS2
Hg19::chr14:81221483..81221489,+	p@chr14:81221483..81221489 +
Hg19::chr16:57954525..57954533,-	p@chr16:57954525..57954533 -
Hg19::chr16:57954541..57954548,-	p@chr16:57954541..57954548 -
Hg19::chr16:79679414..79679446,+	p@chr16:79679414..79679446 +
Hg19::chr16:80068152..80068165,-	p@chr16:80068152..80068165 -
Hg19::chr17:18343257..18343267,+	p2@KRT16P1
Hg19::chr21:44168074..44168079,+	p@chr21:44168074..44168079 +
Hg19::chr2:29149934..29149959,+	p1@SNORD53
Hg19::chr4:155387574..155387588,-	p@chr4:155387574..155387588 -
Hg19::chr4:76481268..76481289,+	p1@C4orf26
Hg19::chr5:64454308..64454313,+	p@chr5:64454308..64454313 +
Hg19::chr7:137570475..137570486,-	p@chr7:137570475..137570486 -
Hg19::chr7:137570496..137570504,-	p@chr7:137570496..137570504 -
Hg19::chr9:16094653..16094654,+	p@chr9:16094653..16094654 +
Hg19::chr9:27524417..27524425,+	p4@IFNK
Hg19::chr9:27524485..27524505,+	p2@IFNK
Hg19::chr9:27524537..27524559,+	p1@IFNK
Hg19::chr9:27524670..27524673,+	p5@IFNK

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	0.0217494896268424
GO:0005132	interferon-alpha/beta receptor binding	0.0217494896268424
GO:0045089	positive regulation of innate immune response	0.0217494896268424
GO:0015936	coenzyme A metabolic process	0.0217494896268424
GO:0045088	regulation of innate immune response	0.0217494896268424
GO:0004806	triacylglycerol lipase activity	0.0254136244685966
GO:0030101	natural killer cell activation	0.0254136244685966

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	1.13e-12	254

Uber Anatomy

Ontology term	p-value	n
extraembryonic membrane	2.65e-07	14
membranous layer	2.65e-07	14
extraembryonic structure	7.79e-07	24

Disease

Ontology term	p-value	n
ovarian cancer	2.49e-07	14
reproductive organ cancer	9.77e-07	29

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
MAFF#23764	3	6.75784277879342	0.00960965044500878	0.0361678720972385
STAT3#6774	11	4.62856459874787	7.15373012922101e-06	0.000206161264063387

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.