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Coexpression cluster:C836

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Full id: C836_Preadipocyte_osteoclastoma_Ewing_Fibroblast_Adipocyte_Osteoblast_hepatic



Phase1 CAGE Peaks

Hg19::chr15:68594466..68594499,-p@chr15:68594466..68594499
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Hg19::chr15:68594930..68594941,-p@chr15:68594930..68594941
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Hg19::chr15:68594981..68594992,-p@chr15:68594981..68594992
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Hg19::chr15:68595021..68595035,-p@chr15:68595021..68595035
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Hg19::chr15:68595063..68595078,-p@chr15:68595063..68595078
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Hg19::chr15:68624258..68624272,-p@chr15:68624258..68624272
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Hg19::chr15:68695318..68695340,-p@chr15:68695318..68695340
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Hg19::chr15:68724490..68724516,-p1@ITGA11
Hg19::chr15:68724518..68724531,-p2@ITGA11
Hg19::chr15:68724544..68724555,-p3@ITGA11


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
dermomyotome1.34e-1270
somite4.16e-1283
paraxial mesoderm4.16e-1283
presomitic mesoderm4.16e-1283
presumptive segmental plate4.16e-1283
trunk paraxial mesoderm4.16e-1283
presumptive paraxial mesoderm4.16e-1283
muscle tissue5.06e-1263
musculature5.06e-1263
musculature of body5.06e-1263
skeletal muscle tissue9.22e-1261
striated muscle tissue9.22e-1261
myotome9.22e-1261
splanchnic layer of lateral plate mesoderm4.75e-1184
organism subdivision1.21e-10365
vasculature2.79e-1079
vascular system2.79e-1079
trunk mesenchyme7.53e-10143
multilaminar epithelium3.73e-0982
vessel3.27e-0869
epithelial tube5.83e-08118
circulatory system6.38e-08113
blood vessel7.69e-0860
epithelial tube open at both ends7.69e-0860
blood vasculature7.69e-0860
vascular cord7.69e-0860
cardiovascular system1.20e-07110
multi-cellular organism2.50e-07659
primary circulatory organ3.79e-0727
cell layer4.78e-07312
heart5.48e-0724
primitive heart tube5.48e-0724
primary heart field5.48e-0724
anterior lateral plate mesoderm5.48e-0724
heart tube5.48e-0724
heart primordium5.48e-0724
cardiac mesoderm5.48e-0724
cardiogenic plate5.48e-0724
heart rudiment5.48e-0724
anatomical cluster6.41e-07286


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SUZ12#23512315.03473427331890.0008575295983126410.00645381088983022



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.