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Coexpression cluster:C4875

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Full id: C4875_leiomyoma_Olfactory_Hair_smallcell_medial_tenocyte_Preadipocyte



Phase1 CAGE Peaks

Hg19::chrX:51638461..51638473,+p7@MAGED1
Hg19::chrX:51638504..51638519,+p5@MAGED1
Hg19::chrX:51638616..51638639,+p4@MAGED1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
somite1.81e-1583
paraxial mesoderm1.81e-1583
presomitic mesoderm1.81e-1583
presumptive segmental plate1.81e-1583
trunk paraxial mesoderm1.81e-1583
presumptive paraxial mesoderm1.81e-1583
trunk mesenchyme2.74e-14143
dermomyotome3.09e-1470
organism subdivision3.42e-14365
skeletal muscle tissue1.14e-1261
striated muscle tissue1.14e-1261
myotome1.14e-1261
multilaminar epithelium1.34e-1282
cell layer2.31e-12312
epithelium3.24e-12309
muscle tissue5.81e-1263
musculature5.81e-1263
musculature of body5.81e-1263
multi-tissue structure1.34e-10347
unilaminar epithelium3.05e-10138
trunk5.70e-10216
splanchnic layer of lateral plate mesoderm8.20e-1084
vasculature1.02e-0979
vascular system1.02e-0979
artery2.28e-0942
arterial blood vessel2.28e-0942
arterial system2.28e-0942
epithelial tube8.04e-09118
multi-cellular organism1.37e-08659
anatomical cluster2.09e-08286
blood vessel4.16e-0860
epithelial tube open at both ends4.16e-0860
blood vasculature4.16e-0860
vascular cord4.16e-0860
systemic artery7.00e-0833
systemic arterial system7.00e-0833
vessel1.75e-0769
anatomical conduit2.21e-07241
tube2.68e-07194


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
YY1#752834.911170749853860.008441455341808260.0331659451675236



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.