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Coexpression cluster:C3495

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Full id: C3495_Mast_granulocyte_acute_CD34_immature_CD133_cord



Phase1 CAGE Peaks

Hg19::chr15:50411412..50411437,-p1@ATP8B4
Hg19::chr15:50411469..50411470,-p16@ATP8B4
Hg19::chr15:50411484..50411496,-p5@ATP8B4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
myeloid cell2.06e-41112
common myeloid progenitor2.06e-41112
hematopoietic stem cell2.75e-41172
angioblastic mesenchymal cell2.75e-41172
hematopoietic cell8.38e-41182
hematopoietic oligopotent progenitor cell3.43e-37165
hematopoietic multipotent progenitor cell3.43e-37165
leukocyte4.05e-23140
myeloid leukocyte1.58e-1976
granulocyte monocyte progenitor cell2.84e-1671
hematopoietic lineage restricted progenitor cell1.09e-15124
myeloid lineage restricted progenitor cell2.23e-1570
macrophage dendritic cell progenitor7.02e-1265
nongranular leukocyte9.69e-12119
monopoietic cell1.37e-1063
monocyte1.37e-1063
monoblast1.37e-1063
promonocyte1.37e-1063
granulocyte1.18e-088
classical monocyte3.96e-0845
CD14-positive, CD16-negative classical monocyte6.64e-0842
mesenchymal cell1.15e-07358
blood cell2.02e-0711
circulating cell3.52e-076
connective tissue cell5.33e-07365
histamine secreting cell6.51e-075
biogenic amine secreting cell6.51e-075
granulocytopoietic cell6.51e-075
mast cell6.51e-075
mast cell progenitor6.51e-075
basophil mast progenitor cell6.51e-075
dendritic cell8.02e-0710
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.76e-25102
blood island3.76e-25102
hemolymphoid system9.91e-23112
bone marrow7.31e-1480
blood6.19e-1315
haemolymphatic fluid6.19e-1315
organism substance6.19e-1315
adult organism4.97e-12115
bone element6.77e-1286
immune system5.87e-11115
skeletal element1.03e-08101
skeletal system1.03e-08101
connective tissue4.35e-07375
Disease
Ontology termp-valuen
myeloid leukemia1.71e-1931
leukemia6.98e-1839
hematologic cancer2.72e-1251
immune system cancer2.72e-1251


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.