Coexpression cluster:C2953

Full id: C2953_Reticulocytes_testicular_leiomyoma_Prostate_Whole_Mesenchymal_hepatoma

Phase1 CAGE Peaks

Hg19::chrX:134049233..134049258,-	p2@MOSPD1
Hg19::chrX:134049262..134049295,-	p1@MOSPD1
Hg19::chrX:134049304..134049323,-	p3@MOSPD1
Hg19::chrX:134049341..134049352,-	p4@MOSPD1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

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Uber Anatomy

Ontology term	p-value	n
reproductive structure	1.75e-08	59
reproductive system	1.75e-08	59
gonad	3.93e-07	21
indifferent external genitalia	3.93e-07	21
indifferent gonad	3.93e-07	21
gonad primordium	3.93e-07	21

Disease

Ontology term	p-value	n
cell type cancer	1.20e-08	143
carcinoma	3.24e-08	106
ovarian cancer	1.25e-07	14
disease of cellular proliferation	2.07e-07	239
reproductive organ cancer	2.50e-07	29

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EGR1#1958	4	4.98817909481014	0.00161501150007605	0.0101706576252076
GABPB1#2553	4	7.06768383618217	0.000400687686442317	0.00391097395180833
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0186729745962922
MYC#4609	4	5.2222818716094	0.00134430939527274	0.00890343895826554
NFKB1#4790	4	5.48806342419384	0.00110219956630198	0.00769675183906207
SIX5#147912	4	17.086715355459	1.17257016123224e-05	0.000298033718834104
SP2#6668	4	26.1535304938446	2.13562021071447e-06	7.76608771541814e-05
SPI1#6688	4	8.20432350852273	0.00022066188152768	0.00250034786208846
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.032356951871343
TAF7#6879	4	11.4330694049239	5.85061525419808e-05	0.00097282663036649
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0245233375863745
TCF12#6938	4	10.6344649021864	7.8163066689251e-05	0.00120348997817466
ZNF143#7702	4	13.5008765522279	3.00867915035614e-05	0.000622594495312155

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.