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Coexpression cluster:C1050

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Full id: C1050_brain_diencephalon_substantia_corpus_occipital_optic_spinal



Phase1 CAGE Peaks

Hg19::chr17:40123919..40123952,+p6@CNP
Hg19::chr17:56598639..56598652,-p@chr17:56598639..56598652
-
Hg19::chr19:36362881..36362902,+p@chr19:36362881..36362902
+
Hg19::chr19:36367441..36367488,+p@chr19:36367441..36367488
+
Hg19::chr19:36370032..36370046,+p@chr19:36370032..36370046
+
Hg19::chr2:128403581..128403584,+p6@GPR17
Hg19::chr2:233740296..233740309,+p10@C2orf82
Hg19::chr2:96686244..96686248,+p@chr2:96686244..96686248
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:00041132',3'-cyclic-nucleotide 3'-phosphodiesterase activity0.0041209802018991
GO:0009214cyclic nucleotide catabolic process0.0041209802018991
GO:0009166nucleotide catabolic process0.017158619785766
GO:0001637G-protein chemoattractant receptor activity0.017158619785766
GO:0004950chemokine receptor activity0.017158619785766
GO:0019956chemokine binding0.017158619785766
GO:0001608nucleotide receptor activity, G-protein coupled0.017158619785766
GO:0045028purinergic nucleotide receptor activity, G-protein coupled0.017158619785766
GO:0016502nucleotide receptor activity0.017158619785766
GO:0001614purinergic nucleotide receptor activity0.017158619785766
GO:0004112cyclic-nucleotide phosphodiesterase activity0.017158619785766
GO:0009187cyclic nucleotide metabolic process0.017158619785766
GO:0048770pigment granule0.0244023979519757
GO:0042470melanosome0.0244023979519757
GO:0019955cytokine binding0.027159637823942
GO:0008081phosphoric diester hydrolase activity0.0338108017026104
GO:0001653peptide receptor activity0.0338108017026104
GO:0008528peptide receptor activity, G-protein coupled0.0338108017026104
GO:0042277peptide binding0.0449771012983651



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of nervous system3.30e-3594
nervous system3.30e-3594
central nervous system3.39e-3382
neural tube1.56e-3157
neural rod1.56e-3157
future spinal cord1.56e-3157
neural keel1.56e-3157
neurectoderm2.99e-3090
neural plate3.68e-2986
presumptive neural plate3.68e-2986
brain3.08e-2669
future brain3.08e-2669
regional part of brain1.18e-2559
regional part of forebrain2.82e-2441
forebrain2.82e-2441
future forebrain2.82e-2441
ectoderm3.99e-24173
presumptive ectoderm3.99e-24173
ectoderm-derived structure4.97e-23169
anterior neural tube5.12e-2342
pre-chordal neural plate1.29e-2061
telencephalon3.01e-2034
gray matter3.09e-2034
brain grey matter3.09e-2034
adult organism7.25e-20115
regional part of telencephalon1.29e-1933
cerebral hemisphere8.15e-1932
head1.06e-18123
anterior region of body4.62e-18129
craniocervical region4.62e-18129
cerebral cortex2.63e-1425
pallium2.63e-1425
regional part of cerebral cortex8.62e-1422
neocortex1.67e-1220
tube7.44e-10194
posterior neural tube1.37e-0915
chordal neural plate1.37e-0915
epithelium1.69e-09309
cell layer2.09e-09312
organism subdivision1.07e-08365
anatomical conduit1.75e-08241
segmental subdivision of nervous system2.70e-0813
segmental subdivision of hindbrain1.30e-0712
hindbrain1.30e-0712
presumptive hindbrain1.30e-0712
organ part1.70e-07219
nucleus of brain1.78e-079
neural nucleus1.78e-079
basal ganglion2.12e-079
nuclear complex of neuraxis2.12e-079
aggregate regional part of brain2.12e-079
collection of basal ganglia2.12e-079
cerebral subcortex2.12e-079
anatomical cluster3.57e-07286


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.