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Coexpression cluster:C719

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Full id: C719_Neutrophils_CD14CD16_CD14_blood_Eosinophils_Peripheral_Monocytederived



Phase1 CAGE Peaks

Hg19::chr10:134401859..134401869,-p@chr10:134401859..134401869
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Hg19::chr12:12871211..12871230,-p@chr12:12871211..12871230
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Hg19::chr15:86098670..86098685,+p26@AKAP13
Hg19::chr17:2303981..2304001,+p@chr17:2303981..2304001
+
Hg19::chr19:10961109..10961114,+p@chr19:10961109..10961114
+
Hg19::chr19:18508474..18508483,-p2@LRRC25
Hg19::chr1:145439323..145439355,+p10@TXNIP
Hg19::chr20:30671781..30671788,+p@chr20:30671781..30671788
+
Hg19::chr3:195627582..195627593,-p@chr3:195627582..195627593
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Hg19::chr6:31583295..31583313,+p9@AIF1
Hg19::chr7:76825469..76825505,-p@chr7:76825469..76825505
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte7.51e-52140
hematopoietic stem cell1.90e-45172
angioblastic mesenchymal cell1.90e-45172
hematopoietic oligopotent progenitor cell2.17e-43165
hematopoietic multipotent progenitor cell2.17e-43165
hematopoietic cell6.17e-41182
nongranular leukocyte9.13e-41119
hematopoietic lineage restricted progenitor cell2.35e-40124
myeloid leukocyte3.41e-3976
granulocyte monocyte progenitor cell4.79e-3571
myeloid cell2.07e-33112
common myeloid progenitor2.07e-33112
macrophage dendritic cell progenitor6.90e-3365
monopoietic cell1.03e-3163
monocyte1.03e-3163
monoblast1.03e-3163
promonocyte1.03e-3163
myeloid lineage restricted progenitor cell2.99e-3170
CD14-positive, CD16-negative classical monocyte2.20e-2942
classical monocyte3.93e-2745
mesenchymal cell1.92e-10358
connective tissue cell1.23e-09365
lymphoid lineage restricted progenitor cell2.92e-0952
lymphocyte3.62e-0953
common lymphoid progenitor3.62e-0953
intermediate monocyte5.41e-089
CD14-positive, CD16-positive monocyte5.41e-089
motile cell3.22e-07390
granulocyte4.06e-078
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.63e-39102
blood island4.63e-39102
hemolymphoid system1.93e-36112
bone marrow8.35e-3280
bone element1.38e-2786
immune system3.88e-24115
skeletal element5.75e-21101
skeletal system5.75e-21101
adult organism4.56e-14115
connective tissue1.42e-08375
lateral plate mesoderm1.61e-08216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.