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Coexpression cluster:C2366

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Full id: C2366_Neutrophils_Eosinophils_leukemia_CD19_caudate_granulocyte_neuroectodermal



Phase1 CAGE Peaks

Hg19::chr16:23847254..23847261,+p2@PRKCB
Hg19::chr16:23847267..23847335,+p1@PRKCB
Hg19::chr16:24060399..24060400,+p@chr16:24060399..24060400
+
Hg19::chr16:24223808..24223818,+p@chr16:24223808..24223818
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell2.80e-61172
angioblastic mesenchymal cell2.80e-61172
hematopoietic oligopotent progenitor cell5.61e-58165
hematopoietic multipotent progenitor cell5.61e-58165
hematopoietic cell2.55e-57182
leukocyte2.87e-49140
hematopoietic lineage restricted progenitor cell4.04e-41124
nongranular leukocyte6.14e-40119
myeloid cell8.50e-35112
common myeloid progenitor8.50e-35112
myeloid leukocyte7.98e-2476
granulocyte monocyte progenitor cell7.04e-2171
lymphocyte3.96e-2053
common lymphoid progenitor3.96e-2053
lymphoid lineage restricted progenitor cell5.67e-2052
myeloid lineage restricted progenitor cell1.60e-1970
macrophage dendritic cell progenitor2.18e-1865
CD14-positive, CD16-negative classical monocyte1.04e-1742
monopoietic cell1.60e-1763
monocyte1.60e-1763
monoblast1.60e-1763
promonocyte1.60e-1763
classical monocyte1.35e-1645
lymphocyte of B lineage7.78e-1224
pro-B cell7.78e-1224
mature alpha-beta T cell4.64e-0918
alpha-beta T cell4.64e-0918
immature T cell4.64e-0918
mature T cell4.64e-0918
immature alpha-beta T cell4.64e-0918
B cell5.65e-0814
T cell6.05e-0825
pro-T cell6.05e-0825
Uber Anatomy
Ontology termp-valuen
adult organism3.39e-30115
hematopoietic system4.65e-27102
blood island4.65e-27102
hemolymphoid system8.75e-23112
bone marrow9.84e-1780
neural tube2.35e-1657
neural rod2.35e-1657
future spinal cord2.35e-1657
neural keel2.35e-1657
anterior neural tube7.07e-1542
regional part of forebrain7.21e-1541
forebrain7.21e-1541
future forebrain7.21e-1541
bone element1.19e-1486
telencephalon4.03e-1434
cerebral hemisphere7.52e-1432
gray matter9.08e-1434
brain grey matter9.08e-1434
regional part of telencephalon1.62e-1333
regional part of brain6.63e-1359
immune system3.65e-12115
central nervous system5.58e-1282
regional part of cerebral cortex7.82e-1222
neocortex2.28e-1120
regional part of nervous system8.36e-1194
nervous system8.36e-1194
brain1.68e-1069
future brain1.68e-1069
neurectoderm3.86e-1090
cerebral cortex4.71e-1025
pallium4.71e-1025
skeletal element7.90e-10101
skeletal system7.90e-10101
blood4.81e-0915
haemolymphatic fluid4.81e-0915
organism substance4.81e-0915
neural plate1.74e-0886
presumptive neural plate1.74e-0886
pre-chordal neural plate9.28e-0861
Disease
Ontology termp-valuen
myeloid leukemia3.42e-1031
hematologic cancer4.48e-1051
immune system cancer4.48e-1051
leukemia1.02e-0939


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.