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Coexpression cluster:C2281

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Full id: C2281_hairy_CD19_b_vein_appendix_lymph_tonsil



Phase1 CAGE Peaks

Hg19::chr14:106114704..106114716,-p1@ENST00000460164
Hg19::chr14:106114739..106114746,-p2@ENST00000460164
Hg19::chr21:42602057..42602083,+p7@BACE2
Hg19::chr2:89161064..89161082,-p1@IGKJ2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0042985negative regulation of amyloid precursor protein biosynthetic process0.00231808548216178
GO:0042983amyloid precursor protein biosynthetic process0.00231808548216178
GO:0042984regulation of amyloid precursor protein biosynthetic process0.00231808548216178
GO:0009049aspartic-type signal peptidase activity0.00231808548216178
GO:0016486peptide hormone processing0.00259625574002119
GO:0009003signal peptidase activity0.00288472860002355
GO:0033619membrane protein proteolysis0.00288472860002355
GO:0006509membrane protein ectodomain proteolysis0.00288472860002355
GO:0042982amyloid precursor protein metabolic process0.00288472860002355
GO:0050435beta-amyloid metabolic process0.00315259625574002
GO:0004194pepsin A activity0.00438328891172409
GO:0009306protein secretion0.00880872483221476
GO:0004190aspartic-type endopeptidase activity0.011656658424585
GO:0042445hormone metabolic process0.011656658424585
GO:0016485protein processing0.0122394913458142
GO:0009101glycoprotein biosynthetic process0.0200718931161302
GO:0006417regulation of translation0.0200718931161302
GO:0031326regulation of cellular biosynthetic process0.0201209819851642
GO:0009100glycoprotein metabolic process0.0201209819851642
GO:0009889regulation of biosynthetic process0.0201209819851642
GO:0032940secretion by cell0.0262274814553161
GO:0046903secretion0.0323689027327318
GO:0051246regulation of protein metabolic process0.0340254634251225



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
blood5.45e-1715
haemolymphatic fluid5.45e-1715
organism substance5.45e-1715
adult organism6.93e-13115
spleen9.07e-083
gastrointestinal system mesentery9.07e-083
stomach region9.07e-083
mesentery9.07e-083
gastrointestinal system serosa9.07e-083
mesentery of stomach9.07e-083
gut mesentery9.07e-083
dorsal mesentery9.07e-083
dorsal mesogastrium9.07e-083
peritoneal cavity9.07e-083
spleen primordium9.07e-083
hemopoietic organ9.19e-087
hemolymphoid system2.38e-07112
hematopoietic system5.67e-07102
blood island5.67e-07102
Disease
Ontology termp-valuen
lymphoma3.19e-1310


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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