Coexpression cluster:C35
From FANTOM5_SSTAR
Full id: C35_caudate_putamen_diencephalon_nucleus_globus_thalamus_insula
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0044459 | plasma membrane part | 3.49188062225331e-18 |
GO:0007154 | cell communication | 4.04548537112757e-17 |
GO:0005886 | plasma membrane | 8.5567689147832e-14 |
GO:0007165 | signal transduction | 2.59847700141666e-13 |
GO:0003008 | system process | 4.3402915108456e-11 |
GO:0016020 | membrane | 8.90853086964345e-11 |
GO:0044425 | membrane part | 3.81448855800484e-10 |
GO:0007186 | G-protein coupled receptor protein signaling pathway | 1.02868011979716e-09 |
GO:0032501 | multicellular organismal process | 1.66342895118553e-09 |
GO:0007268 | synaptic transmission | 5.79980580672754e-09 |
GO:0007166 | cell surface receptor linked signal transduction | 5.93019139387576e-09 |
GO:0007267 | cell-cell signaling | 1.67565323444307e-08 |
GO:0019226 | transmission of nerve impulse | 2.19295186582387e-08 |
GO:0030054 | cell junction | 4.68740365129647e-08 |
GO:0050877 | neurological system process | 4.33492372069729e-07 |
GO:0044464 | cell part | 4.90837209239714e-07 |
GO:0003779 | actin binding | 5.09375024471842e-07 |
GO:0008092 | cytoskeletal protein binding | 2.6959682107413e-06 |
GO:0044456 | synapse part | 8.15172157455421e-06 |
GO:0007242 | intracellular signaling cascade | 1.24271416266784e-05 |
GO:0007187 | G-protein signaling, coupled to cyclic nucleotide second messenger | 1.30237694122029e-05 |
GO:0019935 | cyclic-nucleotide-mediated signaling | 1.58486766550519e-05 |
GO:0005887 | integral to plasma membrane | 1.58486766550519e-05 |
GO:0007212 | dopamine receptor signaling pathway | 1.74726547105737e-05 |
GO:0031226 | intrinsic to plasma membrane | 1.74726547105737e-05 |
GO:0007188 | G-protein signaling, coupled to cAMP nucleotide second messenger | 2.76200365291171e-05 |
GO:0019933 | cAMP-mediated signaling | 3.27512077703987e-05 |
GO:0045211 | postsynaptic membrane | 5.01933103440985e-05 |
GO:0016021 | integral to membrane | 5.46694283904356e-05 |
GO:0031224 | intrinsic to membrane | 6.29194605761999e-05 |
GO:0007399 | nervous system development | 7.68407249719279e-05 |
GO:0005515 | protein binding | 9.72833575581948e-05 |
GO:0022843 | voltage-gated cation channel activity | 0.000149641818533287 |
GO:0065007 | biological regulation | 0.000166597933750868 |
GO:0019932 | second-messenger-mediated signaling | 0.000203075461600173 |
GO:0005737 | cytoplasm | 0.000267722435984773 |
GO:0015629 | actin cytoskeleton | 0.000395039160074976 |
GO:0045761 | regulation of adenylate cyclase activity | 0.000439088167767711 |
GO:0051339 | regulation of lyase activity | 0.000459754940102881 |
GO:0031279 | regulation of cyclase activity | 0.000459754940102881 |
GO:0031420 | alkali metal ion binding | 0.000471349516131385 |
GO:0005856 | cytoskeleton | 0.000607042752531664 |
GO:0005261 | cation channel activity | 0.000607042752531664 |
GO:0005244 | voltage-gated ion channel activity | 0.000607042752531664 |
GO:0022832 | voltage-gated channel activity | 0.000607042752531664 |
GO:0014075 | response to amine stimulus | 0.00173787002255221 |
GO:0007191 | dopamine receptor, adenylate cyclase activating pathway | 0.00173787002255221 |
GO:0001975 | response to amphetamine | 0.00173787002255221 |
GO:0060158 | dopamine receptor, phospholipase C activating pathway | 0.00173787002255221 |
GO:0007190 | adenylate cyclase activation | 0.00173787002255221 |
GO:0046873 | metal ion transmembrane transporter activity | 0.00194411017388452 |
GO:0022836 | gated channel activity | 0.0020870406367725 |
GO:0004888 | transmembrane receptor activity | 0.00216516295425679 |
GO:0000267 | cell fraction | 0.00222035257364126 |
GO:0051349 | positive regulation of lyase activity | 0.00222035257364126 |
GO:0045762 | positive regulation of adenylate cyclase activity | 0.00222035257364126 |
GO:0031281 | positive regulation of cyclase activity | 0.00222035257364126 |
GO:0004930 | G-protein coupled receptor activity | 0.00289822552904634 |
GO:0005216 | ion channel activity | 0.00362020148090754 |
GO:0030001 | metal ion transport | 0.00362020148090754 |
GO:0005624 | membrane fraction | 0.00362020148090754 |
GO:0022838 | substrate specific channel activity | 0.00381972362786136 |
GO:0022803 | passive transmembrane transporter activity | 0.00410357300300284 |
GO:0015267 | channel activity | 0.00410357300300284 |
GO:0007275 | multicellular organismal development | 0.00434198691456024 |
GO:0016323 | basolateral plasma membrane | 0.00447051702695427 |
GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | 0.0050521276938427 |
GO:0007189 | G-protein signaling, adenylate cyclase activating pathway | 0.00540277347838805 |
GO:0008324 | cation transmembrane transporter activity | 0.00544484618504145 |
GO:0031402 | sodium ion binding | 0.00670691125571262 |
GO:0007015 | actin filament organization | 0.00702457903406063 |
GO:0007626 | locomotory behavior | 0.00819644372807439 |
GO:0015672 | monovalent inorganic cation transport | 0.0105666473425826 |
GO:0004385 | guanylate kinase activity | 0.0105666473425826 |
GO:0007610 | behavior | 0.0108357785691984 |
GO:0050789 | regulation of biological process | 0.0118907848867096 |
GO:0007618 | mating | 0.0121168434406504 |
GO:0006874 | cellular calcium ion homeostasis | 0.0121168434406504 |
GO:0055074 | calcium ion homeostasis | 0.0121168434406504 |
GO:0031410 | cytoplasmic vesicle | 0.0130490629795324 |
GO:0031982 | vesicle | 0.0139686248959474 |
GO:0048731 | system development | 0.0139686248959474 |
GO:0006875 | cellular metal ion homeostasis | 0.0139686248959474 |
GO:0055065 | metal ion homeostasis | 0.0139686248959474 |
GO:0006812 | cation transport | 0.0139686248959474 |
GO:0044424 | intracellular part | 0.0139686248959474 |
GO:0001584 | rhodopsin-like receptor activity | 0.0141324595596603 |
GO:0001619 | lysosphingolipid and lysophosphatidic acid receptor activity | 0.0144333995049695 |
GO:0045125 | bioactive lipid receptor activity | 0.0144333995049695 |
GO:0005272 | sodium channel activity | 0.0145830957192617 |
GO:0048519 | negative regulation of biological process | 0.0151698245707305 |
GO:0012505 | endomembrane system | 0.0158685945374056 |
GO:0004871 | signal transducer activity | 0.0161124266880714 |
GO:0060089 | molecular transducer activity | 0.0161124266880714 |
GO:0048856 | anatomical structure development | 0.0186329921249899 |
GO:0032502 | developmental process | 0.019210161674216 |
GO:0007417 | central nervous system development | 0.0194812928167398 |
GO:0030594 | neurotransmitter receptor activity | 0.0200812526799002 |
GO:0008227 | amine receptor activity | 0.020770971325414 |
GO:0005902 | microvillus | 0.020770971325414 |
GO:0007193 | G-protein signaling, adenylate cyclase inhibiting pathway | 0.020770971325414 |
GO:0001518 | voltage-gated sodium channel complex | 0.020770971325414 |
GO:0015459 | potassium channel regulator activity | 0.020770971325414 |
GO:0042165 | neurotransmitter binding | 0.0209550385956687 |
GO:0007204 | elevation of cytosolic calcium ion concentration | 0.021685931503989 |
GO:0051480 | cytosolic calcium ion homeostasis | 0.021685931503989 |
GO:0004952 | dopamine receptor activity | 0.021685931503989 |
GO:0007270 | nerve-nerve synaptic transmission | 0.021685931503989 |
GO:0006171 | cAMP biosynthetic process | 0.021685931503989 |
GO:0035240 | dopamine binding | 0.021685931503989 |
GO:0048666 | neuron development | 0.0242315767376222 |
GO:0007600 | sensory perception | 0.0242315767376222 |
GO:0043085 | positive regulation of catalytic activity | 0.0242315767376222 |
GO:0008021 | synaptic vesicle | 0.0242315767376222 |
GO:0065008 | regulation of biological quality | 0.0242315767376222 |
GO:0048523 | negative regulation of cellular process | 0.0271158064050832 |
GO:0005248 | voltage-gated sodium channel activity | 0.0271158064050832 |
GO:0046058 | cAMP metabolic process | 0.0271158064050832 |
GO:0001505 | regulation of neurotransmitter levels | 0.0271373305496601 |
GO:0015075 | ion transmembrane transporter activity | 0.0280850160916833 |
GO:0019888 | protein phosphatase regulator activity | 0.0280850160916833 |
GO:0005249 | voltage-gated potassium channel activity | 0.0280850160916833 |
GO:0043005 | neuron projection | 0.0280850160916833 |
GO:0019208 | phosphatase regulator activity | 0.0280850160916833 |
GO:0032230 | positive regulation of synaptic transmission, GABAergic | 0.0280850160916833 |
GO:0031528 | microvillus membrane | 0.0280850160916833 |
GO:0004925 | prolactin receptor activity | 0.0280850160916833 |
GO:0005183 | luteinizing hormone-releasing factor activity | 0.0280850160916833 |
GO:0042976 | activation of JAK protein | 0.0280850160916833 |
GO:0030858 | positive regulation of epithelial cell differentiation | 0.0280850160916833 |
GO:0043522 | leucine zipper domain binding | 0.0280850160916833 |
GO:0051370 | ZASP binding | 0.0280850160916833 |
GO:0033781 | cholesterol 24-hydroxylase activity | 0.0280850160916833 |
GO:0005280 | hydrogen:amino acid symporter activity | 0.0280850160916833 |
GO:0008473 | ornithine cyclodeaminase activity | 0.0280850160916833 |
GO:0051374 | FATZ 1 binding | 0.0280850160916833 |
GO:0042977 | tyrosine phosphorylation of JAK2 protein | 0.0280850160916833 |
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 0.0280850160916833 |
GO:0001711 | endodermal cell fate commitment | 0.0280850160916833 |
GO:0015495 | gamma-aminobutyric acid:hydrogen symporter activity | 0.0280850160916833 |
GO:0001590 | dopamine D1 receptor activity | 0.0280850160916833 |
GO:0042641 | actomyosin | 0.0280850160916833 |
GO:0042978 | ornithine decarboxylase activator activity | 0.0280850160916833 |
GO:0006814 | sodium ion transport | 0.0282606040044011 |
GO:0030551 | cyclic nucleotide binding | 0.0282606040044011 |
GO:0007214 | gamma-aminobutyric acid signaling pathway | 0.0303356384941372 |
GO:0007200 | G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | 0.0306603695325305 |
GO:0030005 | cellular di-, tri-valent inorganic cation homeostasis | 0.031791389468235 |
GO:0055066 | di-, tri-valent inorganic cation homeostasis | 0.0334786219543023 |
GO:0035258 | steroid hormone receptor binding | 0.0391560258945665 |
GO:0042995 | cell projection | 0.0420518778812363 |
GO:0042133 | neurotransmitter metabolic process | 0.0420518778812363 |
GO:0051179 | localization | 0.0420518778812363 |
GO:0030003 | cellular cation homeostasis | 0.0420518778812363 |
GO:0030326 | embryonic limb morphogenesis | 0.0420518778812363 |
GO:0035113 | embryonic appendage morphogenesis | 0.0420518778812363 |
GO:0004864 | protein phosphatase inhibitor activity | 0.0420518778812363 |
GO:0055080 | cation homeostasis | 0.0420518778812363 |
GO:0009968 | negative regulation of signal transduction | 0.0420518778812363 |
GO:0048858 | cell projection morphogenesis | 0.0420518778812363 |
GO:0032990 | cell part morphogenesis | 0.0420518778812363 |
GO:0030030 | cell projection organization and biogenesis | 0.0420518778812363 |
GO:0019212 | phosphatase inhibitor activity | 0.0420518778812363 |
GO:0014821 | phasic smooth muscle contraction | 0.0420518778812363 |
GO:0021826 | substrate-independent telencephalic tangential migration | 0.0420518778812363 |
GO:0006540 | glutamate decarboxylation to succinate | 0.0420518778812363 |
GO:0051373 | FATZ binding | 0.0420518778812363 |
GO:0021892 | cerebral cortex GABAergic interneuron differentiation | 0.0420518778812363 |
GO:0005502 | 11-cis retinal binding | 0.0420518778812363 |
GO:0030432 | peristalsis | 0.0420518778812363 |
GO:0021843 | substrate-independent telencephalic tangential interneuron migration | 0.0420518778812363 |
GO:0021894 | cerebral cortex GABAergic interneuron development | 0.0420518778812363 |
GO:0005042 | netrin receptor activity | 0.0420518778812363 |
GO:0007195 | dopamine receptor, adenylate cyclase inhibiting pathway | 0.0420518778812363 |
GO:0006105 | succinate metabolic process | 0.0420518778812363 |
GO:0021830 | interneuron migration from the subpallium to the cortex | 0.0420518778812363 |
GO:0001706 | endoderm formation | 0.0420518778812363 |
GO:0004351 | glutamate decarboxylase activity | 0.0420518778812363 |
GO:0016013 | syntrophin complex | 0.0420518778812363 |
GO:0004987 | kappa-opioid receptor activity | 0.0420518778812363 |
GO:0001973 | adenosine receptor signaling pathway | 0.0420518778812363 |
GO:0032331 | negative regulation of chondrocyte differentiation | 0.0420518778812363 |
GO:0015816 | glycine transport | 0.0420518778812363 |
GO:0001965 | G-protein alpha-subunit binding | 0.0420518778812363 |
GO:0021853 | cerebral cortex GABAergic interneuron migration | 0.0420518778812363 |
GO:0045294 | alpha-catenin binding | 0.0420518778812363 |
GO:0060134 | prepulse inhibition | 0.0420518778812363 |
GO:0030275 | LRR domain binding | 0.0420518778812363 |
GO:0001611 | A2A adenosine receptor activity, G-protein coupled | 0.0420518778812363 |
GO:0007625 | grooming behavior | 0.0420518778812363 |
GO:0001588 | dopamine D1 receptor-like receptor activity | 0.0420518778812363 |
GO:0030182 | neuron differentiation | 0.0420683792178519 |
GO:0016247 | channel regulator activity | 0.0435193681539735 |
GO:0005267 | potassium channel activity | 0.0437236845237935 |
GO:0048736 | appendage development | 0.044181488793002 |
GO:0060173 | limb development | 0.044181488793002 |
GO:0005891 | voltage-gated calcium channel complex | 0.044181488793002 |
GO:0035107 | appendage morphogenesis | 0.044181488793002 |
GO:0035108 | limb morphogenesis | 0.044181488793002 |
GO:0007631 | feeding behavior | 0.044181488793002 |
GO:0000902 | cell morphogenesis | 0.044181488793002 |
GO:0032989 | cellular structure morphogenesis | 0.044181488793002 |
GO:0005622 | intracellular | 0.0446075279686585 |
GO:0042592 | homeostatic process | 0.0446075279686585 |
GO:0019201 | nucleotide kinase activity | 0.0450806908365488 |
GO:0030425 | dendrite | 0.0450806908365488 |
GO:0050767 | regulation of neurogenesis | 0.0450806908365488 |
GO:0030136 | clathrin-coated vesicle | 0.0455252296881115 |
GO:0016023 | cytoplasmic membrane-bound vesicle | 0.0465772260308999 |
GO:0022891 | substrate-specific transmembrane transporter activity | 0.0468493848667038 |
GO:0050953 | sensory perception of light stimulus | 0.0468493848667038 |
GO:0007601 | visual perception | 0.0468493848667038 |
GO:0009190 | cyclic nucleotide biosynthetic process | 0.0482006073658273 |
GO:0031988 | membrane-bound vesicle | 0.0482006073658273 |
GO:0005262 | calcium channel activity | 0.0483452464761841 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
Ontology term | p-value | n |
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Ontology term | p-value | n |
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Ontology term | p-value | n |
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Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
{{{tfbs_overrepresentation_jaspar}}} |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.