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Coexpression cluster:C1733

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Full id: C1733_thymus_thyroid_throat_Hodgkin_CD4_vein_chronic



Phase1 CAGE Peaks

Hg19::chr14:81421324..81421348,+p2@TSHR
Hg19::chr14:81421355..81421379,+p3@TSHR
Hg19::chr14:81421710..81421757,+p4@TSHR
Hg19::chr14:81423399..81423412,+p@chr14:81423399..81423412
+
Hg19::chr14:81423432..81423444,+p@chr14:81423432..81423444
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
lymphocyte8.57e-1053
common lymphoid progenitor8.57e-1053
lymphoid lineage restricted progenitor cell3.28e-0952
T cell9.07e-0725
pro-T cell9.07e-0725
Uber Anatomy
Ontology termp-valuen
adult organism1.23e-18115
neural tube8.38e-1357
neural rod8.38e-1357
future spinal cord8.38e-1357
neural keel8.38e-1357
regional part of brain2.59e-0959
posterior neural tube3.14e-0915
chordal neural plate3.14e-0915
brain1.95e-0869
future brain1.95e-0869
central nervous system6.51e-0882
regional part of nervous system6.91e-0894
nervous system6.91e-0894
neural plate8.52e-0886
presumptive neural plate8.52e-0886
segmental subdivision of hindbrain5.03e-0712
hindbrain5.03e-0712
presumptive hindbrain5.03e-0712
neurectoderm5.37e-0790
regional part of forebrain8.84e-0741
forebrain8.84e-0741
future forebrain8.84e-0741


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.