Coexpression cluster:C713

Full id: C713_skeletal_heart_Renal_aorta_Fibroblast_Smooth_mature

Phase1 CAGE Peaks

Hg19::chr5:150004188..150004308,+	p1@SYNPO
Hg19::chr5:150027636..150027663,+	p2@AB384087
Hg19::chr5:150027742..150027754,+	p3@AB384087
Hg19::chr5:150027815..150027828,+	p1@AB384087
Hg19::chr5:150027838..150027865,+	p6@SYNPO
Hg19::chr5:150027893..150027907,+	p15@SYNPO
Hg19::chr5:150027978..150028011,+	p13@SYNPO
Hg19::chr5:150028043..150028054,+	p23@SYNPO
Hg19::chr5:150028060..150028075,+	p22@SYNPO
Hg19::chr5:150028080..150028174,-	p@chr5:150028080..150028174 -
Hg19::chr5:150028254..150028266,+	p16@SYNPO
Hg19::chr5:150029105..150029117,+	p@chr5:150029105..150029117 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043204	perikaryon	0.0027375485694101
GO:0043197	dendritic spine	0.0027375485694101
GO:0043025	cell soma	0.00857765218415165
GO:0030425	dendrite	0.00857765218415165
GO:0044463	cell projection part	0.00857765218415165
GO:0043005	neuron projection	0.0106460222143726
GO:0005923	tight junction	0.0106460222143726
GO:0043296	apical junction complex	0.0106460222143726
GO:0016327	apicolateral plasma membrane	0.0106460222143726
GO:0045211	postsynaptic membrane	0.0131554417363319
GO:0044456	synapse part	0.0131554417363319
GO:0005911	intercellular junction	0.0131554417363319
GO:0015629	actin cytoskeleton	0.0204012548148896
GO:0042995	cell projection	0.0204012548148896
GO:0030054	cell junction	0.0249801306958672
GO:0003779	actin binding	0.0249801306958672
GO:0008092	cytoskeletal protein binding	0.0323674860265547

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.