Coexpression cluster:C1173

Full id: C1173_medial_Neurons_parietal_temporal_medulloblastoma_occipital_duodenum

Phase1 CAGE Peaks

Hg19::chr12:6804456..6804460,-	p13@C12orf53
Hg19::chr1:151040388..151040403,+	p@chr1:151040388..151040403 +
Hg19::chr1:151040448..151040470,+	p@chr1:151040448..151040470 +
Hg19::chr1:151040524..151040538,+	p@chr1:151040524..151040538 +
Hg19::chr2:162280765..162280777,+	p6@SLC4A10
Hg19::chr4:176594862..176594876,-	p29@GPM6A
Hg19::chr5:73931110..73931127,-	p@chr5:73931110..73931127 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015701	bicarbonate transport	0.0148344369575556
GO:0005452	inorganic anion exchanger activity	0.0203799424963334
GO:0015380	anion exchanger activity	0.0203799424963334
GO:0015106	bicarbonate transmembrane transporter activity	0.0203799424963334
GO:0015301	anion:anion antiporter activity	0.0203799424963334
GO:0015108	chloride transmembrane transporter activity	0.0203799424963334
GO:0015103	inorganic anion transmembrane transporter activity	0.0295885942881831
GO:0006821	chloride transport	0.0295885942881831
GO:0016021	integral to membrane	0.0295885942881831
GO:0031224	intrinsic to membrane	0.0295885942881831
GO:0015297	antiporter activity	0.0295885942881831
GO:0031402	sodium ion binding	0.0295885942881831
GO:0044425	membrane part	0.03799062177336
GO:0009986	cell surface	0.0390393382816885
GO:0006814	sodium ion transport	0.0425601845010815
GO:0008509	anion transmembrane transporter activity	0.0481199389556421
GO:0031420	alkali metal ion binding	0.0481199389556421
GO:0015293	symporter activity	0.049511673759731
GO:0015698	inorganic anion transport	0.0495876489133867
GO:0016020	membrane	0.0495876489133867

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.