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Coexpression cluster:C833

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Full id: C833_pineal_parietal_occipital_temporal_duodenum_cerebellum_brain



Phase1 CAGE Peaks

Hg19::chr14:75389975..75390011,-p2@RPS6KL1
Hg19::chr14:93897057..93897102,+p1@UNC79
Hg19::chr14:93897272..93897310,+p2@UNC79
Hg19::chr16:89894845..89894856,+p2@SPIRE2
Hg19::chr17:19314365..19314387,+p3@RNF112
Hg19::chr1:151689259..151689285,-p1@CELF3
Hg19::chr1:45672027..45672050,-p1@ZSWIM5
Hg19::chr1:65775204..65775248,+p4@DNAJC6
Hg19::chr5:131705540..131705599,-p1@LOC553103
Hg19::chr9:109625401..109625458,+p1@ZNF462


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism1.93e-44115
regional part of nervous system1.33e-3694
nervous system1.33e-3694
central nervous system6.06e-3682
neural tube2.40e-3257
neural rod2.40e-3257
future spinal cord2.40e-3257
neural keel2.40e-3257
brain1.47e-2969
future brain1.47e-2969
regional part of brain6.26e-2759
anterior neural tube8.31e-2642
regional part of forebrain8.55e-2641
forebrain8.55e-2641
future forebrain8.55e-2641
neural plate1.11e-2586
presumptive neural plate1.11e-2586
ectoderm-derived structure1.11e-25169
ectoderm1.54e-25173
presumptive ectoderm1.54e-25173
neurectoderm4.22e-2590
telencephalon2.23e-2134
gray matter2.54e-2134
brain grey matter2.54e-2134
head4.42e-21123
anterior region of body8.81e-21129
craniocervical region8.81e-21129
regional part of telencephalon9.39e-2133
cerebral hemisphere2.33e-2032
pre-chordal neural plate1.89e-1961
cerebral cortex3.90e-1625
pallium3.90e-1625
anatomical conduit1.26e-15241
regional part of cerebral cortex1.64e-1522
anatomical cluster6.27e-15286
neocortex2.79e-1420
multi-tissue structure7.78e-14347
tube6.71e-13194
organism subdivision1.63e-10365
organ part8.08e-10219
epithelium2.23e-09309
cell layer2.94e-09312
embryo3.25e-09612
multi-cellular organism8.35e-09659
posterior neural tube9.74e-0815
chordal neural plate9.74e-0815
embryonic structure1.46e-07605
developing anatomical structure1.46e-07605
germ layer2.38e-07604
embryonic tissue2.38e-07604
presumptive structure2.38e-07604
epiblast (generic)2.38e-07604
anatomical system2.59e-07625
anatomical group2.70e-07626
organ2.90e-07511
basal ganglion9.59e-079
nuclear complex of neuraxis9.59e-079
aggregate regional part of brain9.59e-079
collection of basal ganglia9.59e-079
cerebral subcortex9.59e-079
Disease
Ontology termp-valuen
cell type cancer4.16e-09143
carcinoma4.52e-07106


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.