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{{CL
{{CL
|id=CL:0002224
|alt_id=
|name=lens epithelial cell
|namespace=cell
|def="A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
|xref=FMA:67559
|is_a=CL:0000075;;CL:0002222
|synonym=
|comment=
|comment=
|alt_id=
|disjoint_from=
|union_of=
|created_by=tmeehan
|created_by=tmeehan
|obo_creation_date=2010-09-07T10:45:47Z
|def="A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
|subset=
|derives_from=
|derives_from=
|develops_from=
|develops_from=
|disjoint_from=
|has_quality=
|has_quality=
|id=CL:0002224
|is_a=CL:0000075 ;;CL:0002222
|is_obsolete=
|located_in=
|located_in=
|name=lens epithelial cell
|namespace=cell
|obo_creation_date=2010-09-07T10:45:47Z
|part_of=UBERON:0001803
|part_of=UBERON:0001803
|preceded_by=
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl
|property_value=IAO:0000412 http://purl.obolibrary.org/obo/cl-to-uberon.owl;;IAO:0000412 http://purl.obolibrary.org/obo/cl.owl
|is_obsolete=
|subset=
|preceded_by=
|synonym=
|union_of=
|xref=FMA:67559
}}
}}

Revision as of 10:25, 12 September 2014

Name:lens epithelial cell
Namespace:cell
Definition:"A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [GOC:tfm, http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium, ISBN:0721662544]
Xrefs:
links:
FMA:67559
Created by:tmeehan
Creation date:2010-09-07T10:45:47Z


Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:CL:0000075(columnar/cuboidal epithelial cell),CL:0002222(vertebrate lens cell)
part_of:UBERON:0001803(epithelium of lens)



Children


is a:FF:10647-109A8 (lens epithelial cell line:SRA 01/04)
derives from:FF:0000085 (human lens epithelial cell sample),FF:0101874 (lens epithelial cell line sample)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)


FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.

Human (Homo sapiens)

Mouse (Mus musculus)


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0002224 (lens epithelial cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
1.41e-88FFCP PHASE2:Hg19::chr22:25595823..25595826,+#_c79805b31d40abedb1e461788f43f1afp1@CRYBB3
1.41e-88FFCP PHASE1:Hg19::chr22:25595823..25595826,+#_c79805b31d40abedb1e461788f43f1afp1@CRYBB3
3.32e-74FFCP PHASE2:Hg19::chr22:25615600..25615611,+#_8c620954a636fdc13e9ed5402f803d2cp1@CRYBB2
3.32e-74FFCP PHASE1:Hg19::chr22:25615600..25615611,+#_8c620954a636fdc13e9ed5402f803d2cp1@CRYBB2
5.48e-74FFCP PHASE2:Hg19::chr19:51891222..51891233,-#_7e71c8e0285a7f40010c36106ff61be4p1@LIM2
5.48e-74FFCP PHASE1:Hg19::chr19:51891222..51891233,-#_7e71c8e0285a7f40010c36106ff61be4p1@LIM2
3.8e-56FFCP PHASE1:Hg19::chr22:27017921..27017928,+#_0cadfdf6e5c295a521ac826690567aeap1@CRYBA4
3.8e-56FFCP PHASE2:Hg19::chr22:27017921..27017928,+#_0cadfdf6e5c295a521ac826690567aeap1@CRYBA4
3.1e-50FFCP PHASE1:Hg19::chr20:61204240..61204241,+#_4b7384f1d5ae52f3a79ac3cdbf959ba8p@chr20:61204240..61204241, +
3.1e-50FFCP PHASE1:Hg19::chr13:104778247..104778293,+#_4b7384f1d5ae52f3a79ac3cdbf959ba8p@chr13:104778247..104778293, +
3.1e-50FFCP PHASE2:Hg19::chr13:104778247..104778293,+#_4b7384f1d5ae52f3a79ac3cdbf959ba8p@chr13:104778247..104778293, +
3.1e-50FFCP PHASE2:Hg19::chr20:61204240..61204241,+#_4b7384f1d5ae52f3a79ac3cdbf959ba8p@chr20:61204240..61204241, +
5.14e-50FFCP PHASE2:Hg19::chr21:44592820..44592840,-#_cb12312e65231cf7e01ee02bd2a4c3f6p2@CU686889
5.14e-50FFCP PHASE1:Hg19::chr21:44592820..44592840,-#_cb12312e65231cf7e01ee02bd2a4c3f6p2@CU686889
5.14e-50FFCP PHASE1:Hg19::chr14:37642016..37642022,-#_cb12312e65231cf7e01ee02bd2a4c3f6p7@SLC25A21
5.14e-50FFCP PHASE2:Hg19::chr14:37642016..37642022,-#_cb12312e65231cf7e01ee02bd2a4c3f6p7@SLC25A21
6.6e-50FFCP PHASE1:Hg19::chr21:44589339..44589372,-#_d0f684a0fd03fff3259002f81f5de4f2p@chr21:44589339..44589372, -
6.6e-50FFCP PHASE2:Hg19::chr21:44592842..44592867,-#_d0f684a0fd03fff3259002f81f5de4f2p1@CU686889
6.6e-50FFCP PHASE2:Hg19::chr12:132475501..132475504,+#_d0f684a0fd03fff3259002f81f5de4f2p@chr12:132475501..132475504, +
6.6e-50FFCP PHASE1:Hg19::chr12:132475501..132475504,+#_d0f684a0fd03fff3259002f81f5de4f2p@chr12:132475501..132475504, +
6.6e-50FFCP PHASE2:Hg19::chr21:44589339..44589372,-#_d0f684a0fd03fff3259002f81f5de4f2p@chr21:44589339..44589372, -
6.6e-50FFCP PHASE1:Hg19::chr21:44592842..44592867,-#_d0f684a0fd03fff3259002f81f5de4f2p1@CU686889
6.27e-44FFCP PHASE1:Hg19::chr11:31827535..31827565,-#_ba01e6c97373209799fae105d0a0f17cp11@PAX6
6.27e-44FFCP PHASE2:Hg19::chr11:31827535..31827565,-#_ba01e6c97373209799fae105d0a0f17cp11@PAX6
1.92e-41FFCP PHASE2:Hg19::chr3:186262166..186262170,-#_d7fd12bdea244afac4a4c7f6fd1ee31fp1@CRYGS
1.92e-41FFCP PHASE1:Hg19::chr3:186262166..186262170,-#_d7fd12bdea244afac4a4c7f6fd1ee31fp1@CRYGS
4.94e-40FFCP PHASE2:Hg19::chr5:112173525..112173532,+#_b3bbb558b64545ae696ce58ebb9b3061p@chr5:112173525..112173532, +
4.94e-40FFCP PHASE1:Hg19::chr5:112173525..112173532,+#_b3bbb558b64545ae696ce58ebb9b3061p@chr5:112173525..112173532, +
1.62e-37FFCP PHASE2:Hg19::chr1:29586692..29586705,+#_992578449e75fdc6c9b7942e6b456edbp7@PTPRU
1.62e-37FFCP PHASE1:Hg19::chr1:29586692..29586705,+#_992578449e75fdc6c9b7942e6b456edbp7@PTPRU
2.1e-35FFCP PHASE2:Hg19::chr14:60975644..60975673,+#_ecfd04328dbc1858f4a54ab6566836fap3@SIX6
2.1e-35FFCP PHASE1:Hg19::chr14:60975644..60975673,+#_ecfd04328dbc1858f4a54ab6566836fap3@SIX6
6.73e-35FFCP PHASE1:Hg19::chr14:60975871..60975880,+#_b667619d389e16440e0df704a6111017p4@SIX6
6.73e-35FFCP PHASE2:Hg19::chr14:60975871..60975880,+#_b667619d389e16440e0df704a6111017p4@SIX6
5.06e-34FFCP PHASE2:Hg19::chr11:31667372..31667383,-#_18ffff1fe424e6f2fd0db23784b561dbp@chr11:31667372..31667383, -
5.06e-34FFCP PHASE1:Hg19::chr11:31667372..31667383,-#_18ffff1fe424e6f2fd0db23784b561dbp@chr11:31667372..31667383, -
8.36e-34FFCP PHASE2:Hg19::chr19:1470631..1470648,-#_c565794f3731458029543f17abf2dd7cp@chr19:1470631..1470648, -
8.36e-34FFCP PHASE1:Hg19::chr19:1470631..1470648,-#_c565794f3731458029543f17abf2dd7cp@chr19:1470631..1470648, -
5.55e-33FFCP PHASE2:Hg19::chr21:44589135..44589151,+#_f116b67c433d1a304ceeb6a5798281d9p1@CRYAA
5.55e-33FFCP PHASE1:Hg19::chr21:44589135..44589151,+#_f116b67c433d1a304ceeb6a5798281d9p1@CRYAA
9.55e-33FFCP PHASE2:Hg19::chr17:27573875..27573878,+#_c49eb76f6d7eb493c2635a621848b8e0p1@CRYBA1
9.55e-33FFCP PHASE1:Hg19::chr17:27573875..27573878,+#_c49eb76f6d7eb493c2635a621848b8e0p1@CRYBA1
2.74e-29FFCP PHASE1:Hg19::chr2:45168589..45168601,-#_30d107272c71d65c16b93d74113a2c1dp2@ENST00000456467
2.74e-29FFCP PHASE2:Hg19::chr2:45168589..45168601,-#_30d107272c71d65c16b93d74113a2c1dp2@ENST00000456467
3.65e-29FFCP PHASE1:Hg19::chr7:107883678..107883689,-#_ddfba0cf2f5a356f553069d4a182aa1dp13@NRCAM
3.65e-29FFCP PHASE2:Hg19::chr7:107883678..107883689,-#_ddfba0cf2f5a356f553069d4a182aa1dp13@NRCAM
7.46e-29FFCP PHASE1:Hg19::chr13:114202163..114202178,+#_af43184cd4647f1b8ebd0fe4475f1c13p@chr13:114202163..114202178, +
7.46e-29FFCP PHASE2:Hg19::chr13:114202163..114202178,+#_af43184cd4647f1b8ebd0fe4475f1c13p@chr13:114202163..114202178, +
1.36e-28FFCP PHASE2:Hg19::chr3:173116225..173116242,+#_345e96d25105c6472013b99d83047a44p10@NLGN1
1.36e-28FFCP PHASE1:Hg19::chr3:173116225..173116242,+#_345e96d25105c6472013b99d83047a44p10@NLGN1
2.64e-27FFCP PHASE1:Hg19::chr2:45169233..45169244,+#_da7138f9e7914724712621f3962f7518p10@SIX3
2.64e-27FFCP PHASE2:Hg19::chr2:45169233..45169244,+#_da7138f9e7914724712621f3962f7518p10@SIX3
8.39e-27FFCP PHASE1:Hg19::chr14:60975858..60975869,+#_e353246972a352cc94b2e2f2291ce1afp2@SIX6
8.39e-27FFCP PHASE2:Hg19::chr14:60975858..60975869,+#_e353246972a352cc94b2e2f2291ce1afp2@SIX6
5.56e-26FFCP PHASE2:Hg19::chr19:40920692..40920700,-#_a75c40084224e74d564d4be148c2e894p@chr19:40920692..40920700, -
5.56e-26FFCP PHASE1:Hg19::chr20:35861148..35861151,+#_a75c40084224e74d564d4be148c2e894p@chr20:35861148..35861151, +
5.56e-26FFCP PHASE2:Hg19::chr3:150690809..150690822,-#_a75c40084224e74d564d4be148c2e894p3@CLRN1
5.56e-26FFCP PHASE1:Hg19::chr9:75848662..75848671,-#_a75c40084224e74d564d4be148c2e894p@chr9:75848662..75848671, -
5.56e-26FFCP PHASE2:Hg19::chrX:43587410..43587413,+#_a75c40084224e74d564d4be148c2e894p@chrX:43587410..43587413, +
5.56e-26FFCP PHASE1:Hg19::chr19:40920692..40920700,-#_a75c40084224e74d564d4be148c2e894p@chr19:40920692..40920700, -
5.56e-26FFCP PHASE2:Hg19::chr1:147374915..147374932,+#_a75c40084224e74d564d4be148c2e894p1@GJA8
5.56e-26FFCP PHASE1:Hg19::chr3:150690809..150690822,-#_a75c40084224e74d564d4be148c2e894p3@CLRN1
5.56e-26FFCP PHASE2:Hg19::chr20:35861148..35861151,+#_a75c40084224e74d564d4be148c2e894p@chr20:35861148..35861151, +
5.56e-26FFCP PHASE1:Hg19::chrX:43587410..43587413,+#_a75c40084224e74d564d4be148c2e894p@chrX:43587410..43587413, +
5.56e-26FFCP PHASE2:Hg19::chr9:75848662..75848671,-#_a75c40084224e74d564d4be148c2e894p@chr9:75848662..75848671, -
5.56e-26FFCP PHASE1:Hg19::chr1:147374915..147374932,+#_a75c40084224e74d564d4be148c2e894p1@GJA8
7.14e-26FFCP PHASE2:Hg19::chr1:115873480..115873484,+#_297ac642cc4885f144782f3b22386b45p@chr1:115873480..115873484, +
7.14e-26FFCP PHASE2:Hg19::chr5:45038620..45038622,+#_297ac642cc4885f144782f3b22386b45p@chr5:45038620..45038622, +
7.14e-26FFCP PHASE2:Hg19::chr5:124468141..124468176,-#_297ac642cc4885f144782f3b22386b45p@chr5:124468141..124468176, -
7.14e-26FFCP PHASE2:Hg19::chr2:693025..693036,+#_297ac642cc4885f144782f3b22386b45p@chr2:693025..693036, +
7.14e-26FFCP PHASE2:Hg19::chr2:10538258..10538282,+#_297ac642cc4885f144782f3b22386b45p@chr2:10538258..10538282, +
7.14e-26FFCP PHASE1:Hg19::chr2:45154282..45154288,-#_297ac642cc4885f144782f3b22386b45p@chr2:45154282..45154288, -
7.14e-26FFCP PHASE1:Hg19::chr21:44592750..44592758,-#_297ac642cc4885f144782f3b22386b45p4@CU686889
7.14e-26FFCP PHASE1:Hg19::chr4:140656282..140656285,-#_297ac642cc4885f144782f3b22386b45p@chr4:140656282..140656285, -
7.14e-26FFCP PHASE1:Hg19::chr12:56848437..56848442,-#_297ac642cc4885f144782f3b22386b45p1@MIP
7.14e-26FFCP PHASE1:Hg19::chr13:44875179..44875188,-#_297ac642cc4885f144782f3b22386b45p@chr13:44875179..44875188, -
7.14e-26FFCP PHASE1:Hg19::chr1:45769711..45769721,-#_297ac642cc4885f144782f3b22386b45p@chr1:45769711..45769721, -
7.14e-26FFCP PHASE2:Hg19::chr5:464155..464205,+#_297ac642cc4885f144782f3b22386b45p@chr5:464155..464205, +
7.14e-26FFCP PHASE2:Hg19::chr16:85617064..85617073,-#_297ac642cc4885f144782f3b22386b45p@chr16:85617064..85617073, -
7.14e-26FFCP PHASE1:Hg19::chr21:44592358..44592365,+#_297ac642cc4885f144782f3b22386b45p@chr21:44592358..44592365, +
7.14e-26FFCP PHASE1:Hg19::chr1:115873480..115873484,+#_297ac642cc4885f144782f3b22386b45p@chr1:115873480..115873484, +
7.14e-26FFCP PHASE2:Hg19::chr21:44592512..44592521,+#_297ac642cc4885f144782f3b22386b45p@chr21:44592512..44592521, +
7.14e-26FFCP PHASE1:Hg19::chr20:33903184..33903189,-#_297ac642cc4885f144782f3b22386b45p11@UQCC
7.14e-26FFCP PHASE1:Hg19::chr5:124468141..124468176,-#_297ac642cc4885f144782f3b22386b45p@chr5:124468141..124468176, -
7.14e-26FFCP PHASE2:Hg19::chr12:56848437..56848442,-#_297ac642cc4885f144782f3b22386b45p1@MIP
7.14e-26FFCP PHASE2:Hg19::chr21:36253916..36253918,-#_297ac642cc4885f144782f3b22386b45p@chr21:36253916..36253918, -
7.14e-26FFCP PHASE2:Hg19::chr8:94870047..94870056,+#_297ac642cc4885f144782f3b22386b45p30@PDP1
7.14e-26FFCP PHASE2:Hg19::chr13:44875179..44875188,-#_297ac642cc4885f144782f3b22386b45p@chr13:44875179..44875188, -
7.14e-26FFCP PHASE1:Hg19::chr21:44592788..44592807,+#_297ac642cc4885f144782f3b22386b45p@chr21:44592788..44592807, +
7.14e-26FFCP PHASE1:Hg19::chr11:65361417..65361421,-#_297ac642cc4885f144782f3b22386b45p2@KCNK7
7.14e-26FFCP PHASE2:Hg19::chr11:65361417..65361421,-#_297ac642cc4885f144782f3b22386b45p2@KCNK7
7.14e-26FFCP PHASE1:Hg19::chr2:10538258..10538282,+#_297ac642cc4885f144782f3b22386b45p@chr2:10538258..10538282, +
7.14e-26FFCP PHASE1:Hg19::chr1:86064794..86064797,+#_297ac642cc4885f144782f3b22386b45p1@ENST00000426794
7.14e-26FFCP PHASE2:Hg19::chr3:156322310..156322314,-#_297ac642cc4885f144782f3b22386b45p@chr3:156322310..156322314, -
7.14e-26FFCP PHASE1:Hg19::chr5:45038620..45038622,+#_297ac642cc4885f144782f3b22386b45p@chr5:45038620..45038622, +
7.14e-26FFCP PHASE2:Hg19::chr19:41727698..41727705,+#_297ac642cc4885f144782f3b22386b45p@chr19:41727698..41727705, +
7.14e-26FFCP PHASE2:Hg19::chr7:123198284..123198329,-#_297ac642cc4885f144782f3b22386b45p3@NDUFA5
7.14e-26FFCP PHASE2:Hg19::chr21:44592626..44592635,-#_297ac642cc4885f144782f3b22386b45p5@CU686889
7.14e-26FFCP PHASE2:Hg19::chr16:17563573..17563582,+#_297ac642cc4885f144782f3b22386b45p@chr16:17563573..17563582, +
7.14e-26FFCP PHASE1:Hg19::chr2:693025..693036,+#_297ac642cc4885f144782f3b22386b45p@chr2:693025..693036, +

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